DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and Ifit2

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001019924.1	Gene:	Ifit2 / 294091	RGDID:	1307804	Length:	464	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	74/384 - (19%)
Similarity:	128/384 - (33%)	Gaps:	142/384 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 EKVSIIEEKHQDEHYVNALCKLGH---LHLLLGEYSEALSAYQKYL------------RFRENNY 148
            |....|.::|.|:..:.:|...|:   ::..:|:.|:|    |:||            .:|..|.
  Rat    76 EAEDFIRQQHPDQIEIKSLVTWGNYAWVYYHMGQLSKA----QEYLDKVKQVCKKFSSPYRIENP 136

  Fly   149 WTNHAFIYGIGVAYFKLRCFK--------------------------WAIKSFQELLYLSPNFTC 187
                  :......:.:|:|.|                          |||.:     |...::..
  Rat   137 ------VLDCEEGWARLKCTKNQNERMKVCFEKALEKDPKNPESTSGWAIAN-----YRLDDWPA 190

  Fly   188 ANEVHLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEF 252
            :|:.                 :..|:.|:..:..:|:.::.:..::..::|.:.|.
  Rat   191 SNDY-----------------IDSLEQAISLSPDNTYVKVLLAMKLEEVHENRAKE--------- 229

  Fly   253 LLNEKNISLELKAD---VYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGR 314
            |:.|     .||.|   :...||.....|     |......|:..|:|::|:.|.:....|.||.
  Rat   230 LVEE-----ALKKDPSAIDTMLGAAKFYV-----KVHDTDRAIQLLKKALESMPNNAYVHYYLGC 284

  Fly   315 CYAGINKVHDAFLAYRNSVE-KSEGNADTWCSIGVLYQQQNQPTDAL-QAYICAVQLDKDHKAAW 377
            ||.  :||    |...|:.| .|.||              .:..:|| |..:..::..:|.|.
  Rat   285 CYR--SKV----LHILNTEETTSNGN--------------REKLEALIQPALNHLRKAEDIKE-- 327

  Fly   378 TNLGILYESCGQLRDAYACYLNATKQIS-----FQKSSLIRKKQAIRMKKDTIGLSKGL 431
                ::..||..|...|.    .|||..     |||          ...||...|.|.|
  Rat   328 ----MIENSCSHLAGLYV----TTKQYEEADYYFQK----------EFNKDLRPLPKQL 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	7/59 (12%)
		TPR_11	156..216	CDD:290150	9/85 (11%)
		TPR repeat	186..216	CDD:276809	2/29 (7%)
		TPR repeat	228..255	CDD:276809	3/26 (12%)
		TPR_11	264..337	CDD:290150	21/76 (28%)
		TPR repeat	265..300	CDD:276809	8/37 (22%)
		TPR repeat	307..334	CDD:276809	9/26 (35%)
		TPR_11	339..402	CDD:290150	10/63 (16%)
		TPR repeat	339..369	CDD:276809	4/30 (13%)
		TPR_1	340..373	CDD:278916	3/33 (9%)
		TPR repeat	374..402	CDD:276809	5/27 (19%)
		JmjC	870..978	CDD:202224
Ifit2	NP_001019924.1	TPR_12	51..126	CDD:290160	12/53 (23%)
		TPR repeat	96..122	CDD:276809	7/29 (24%)
		TPR repeat	127..167	CDD:276809	5/45 (11%)
		TPR repeat	242..270	CDD:276809	7/32 (22%)
		TPR repeat	275..325	CDD:276809	16/69 (23%)
		TPR repeat	330..355	CDD:276809	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900