DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and Tmtc4

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_006252585.1	Gene:	Tmtc4 / 290501	RGDID:	1560183	Length:	773	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	68/341 - (19%)
Similarity:	121/341 - (35%)	Gaps:	88/341 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 AFIYGIGVAYFKLRCF----KWAIKS--FQELLYLSPNFTCANEVHLRLGLMLKHCGEFHIALKH 211
            |.|.|| :....|||.    :|..:.  |:..|.:.|   ...:||..:|..|...|....|:|:
  Rat   476 AIILGI-LLINALRCVIRSGEWRSEDRLFRSALSVCP---LNAKVHYNIGKNLADQGNQTAAIKY 536

  Fly   212 LQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYH 276
            .:.|:                     .:..|:..|.:....:|.|:|
  Rat   537 YREAV---------------------RLNPKYVHAMNNLGNILKERN------------------ 562

  Fly   277 CVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNAD 341
                  |.:|.|    ..|..:::..|....:...||.....:.:..:|..:||.:::......|
  Rat   563 ------ELQEAE----ELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPD 617

  Fly   342 TWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATK---- 402
            .:.::|.||...|:..|||.|:..|..:..:|..||.|:.||.::.|.|..|.|....|.:
  Rat   618 CYYNLGRLYADLNRHVDALNAWRNATVMKPEHSLAWNNMVILLDNTGNLAQAEAVGREALQLIPN 682

  Fly   403 --QISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLCSIEEAW- 464
              .:.|..::::.|.|            |.......||:...:.   |::.|....|..:...|
  Rat   683 DHSLMFSLANVLGKSQ------------KYKESEALFLKAIKAN---PNVASYHGNLAVLYHRWG 732

  Fly   465 -------NLPISLEMN 473
                   :..|||:::
  Rat   733 HLDSAKKHYEISLQLD 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	10/33 (30%)
		TPR_11	156..216	CDD:290150	16/65 (25%)
		TPR repeat	186..216	CDD:276809	7/29 (24%)
		TPR repeat	228..255	CDD:276809	2/26 (8%)
		TPR_11	264..337	CDD:290150	10/72 (14%)
		TPR repeat	265..300	CDD:276809	4/34 (12%)
		TPR repeat	307..334	CDD:276809	5/26 (19%)
		TPR_11	339..402	CDD:290150	21/62 (34%)
		TPR repeat	339..369	CDD:276809	10/29 (34%)
		TPR_1	340..373	CDD:278916	10/32 (31%)
		TPR repeat	374..402	CDD:276809	10/27 (37%)
		JmjC	870..978	CDD:202224
Tmtc4	XP_006252585.1	DUF1736	324..398	CDD:285594
		TPR	513..771	CDD:223533	57/300 (19%)
		TPR_1	514..547	CDD:278916	8/53 (15%)
		TPR repeat	514..542	CDD:276809	8/48 (17%)
		TPR_17	536..569	CDD:290167	9/81 (11%)
		TPR repeat	547..577	CDD:276809	8/57 (14%)
		TPR_1	582..615	CDD:278916	5/32 (16%)
		TPR repeat	582..610	CDD:276809	5/27 (19%)
		TPR repeat	616..642	CDD:276809	9/25 (36%)
		TPR repeat	650..678	CDD:276809	10/27 (37%)
		TPR repeat	683..713	CDD:276809	6/41 (15%)
		TPR_17	706..739	CDD:290167	6/35 (17%)
		TPR repeat	718..746	CDD:276809	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900