DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and Tmtc2

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_796342.2	Gene:	Tmtc2 / 278279	MGIID:	1914057	Length:	836	Species:	Mus musculus

Alignment Length:	347	Identity:	74/347 - (21%)
Similarity:	137/347 - (39%)	Gaps:	54/347 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LGHLHLLLGEYSEALSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPN 184
            ||::.....:.|||.|||:..|.:|.|    ....:|.:|:...:...|..|:..::..:...|.
Mouse   499 LGNVLKSQSKISEAESAYRNALFYRSN----MADMLYNLGLLLQENSRFAEALHYYKLAIGSRPT 559

  Fly   185 FTCANEVHLRLGLMLKHCGEFHIA----LKHLQLA---LLYTYPSTFSELQVKFQIAHLYEVQNK 242
            ...|   :|..|::|.:.|:...|    ||..::.   |...:....|.....:.:..||..|.:
Mouse   560 LASA---YLNTGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGR 621

  Fly   243 HKAAKDGYEFLLNE--KNISLELKADVYRQLGWMY----------H-CVECLGEKKE-------- 286
            ::.|...|...:.:  ::.:.:   .:|..:|..|          | .:|.|..|.:
Mouse   622 YEEALSVYREAIQKMPRHFAPQ---SLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTY 683

  Fly   287 --------REANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTW 343
                    |::.|..|..|:||.||..|......|:.....:::.:|....:.:.|......|..
Mouse   684 GKLLALTGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDNTEFDVV 748

  Fly   344 CSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATK------ 402
            .:...:.:|.:....|.:.|..|.:|..::.||..|||.:....|:|:.|.|.||.|.:
Mouse   749 FNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDV 813

  Fly   403 --QISFQKSSLIRKKQAIRMKK 422
              |.:.:|...|.:||.::..|
Mouse   814 ITQSNLRKLWNIMEKQGLKTSK 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	4/33 (12%)
		TPR_11	156..216	CDD:290150	13/66 (20%)
		TPR repeat	186..216	CDD:276809	8/36 (22%)
		TPR repeat	228..255	CDD:276809	5/26 (19%)
		TPR_11	264..337	CDD:290150	19/99 (19%)
		TPR repeat	265..300	CDD:276809	11/61 (18%)
		TPR repeat	307..334	CDD:276809	2/26 (8%)
		TPR_11	339..402	CDD:290150	18/62 (29%)
		TPR repeat	339..369	CDD:276809	5/29 (17%)
		TPR_1	340..373	CDD:278916	6/32 (19%)
		TPR repeat	374..402	CDD:276809	12/27 (44%)
		JmjC	870..978	CDD:202224
Tmtc2	NP_796342.2	DUF1736	247..321	CDD:285594
		TPR 1	460..492
		TPR_11	493..554	CDD:290150	15/58 (26%)
		TPR 2	493..526		11/30 (37%)
		TPR repeat	493..521	CDD:276809	8/21 (38%)
		TPR_1	493..>520	CDD:278916	8/20 (40%)
		TPR 3	527..560		5/32 (16%)
		TPR repeat	527..555	CDD:276809	4/27 (15%)
		TPR_12	557..634	CDD:290160	16/79 (20%)
		TPR repeat	560..590	CDD:276809	8/32 (25%)
		TPR 4	562..594		8/34 (24%)
		TPR repeat	595..634	CDD:276809	7/38 (18%)
		TPR 5	606..639		5/32 (16%)
		TPR_2	609..639	CDD:285020	5/29 (17%)
		ANAPC3	618..703	CDD:289650	13/87 (15%)
		TPR repeat	642..671	CDD:276809	5/31 (16%)
		TPR 6	643..676		7/35 (20%)
		TPR 7	677..710		8/32 (25%)
		TPR repeat	679..705	CDD:276809	4/25 (16%)
		TPR repeat	710..774	CDD:276809	9/63 (14%)
		TPR 8	712..744		3/31 (10%)
		TPR 9	746..778		6/31 (19%)
		TPR_19	755..822	CDD:291240	18/66 (27%)
		TPR 10	779..812		12/32 (38%)
		TPR_1	779..812	CDD:278916	12/32 (38%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900