Protein Alignment Utx and Tmtc2

DIOPT Version :10

• Sequence 1: NP_609368.3
• Gene: Utx / 34377
• FlyBaseID: FBgn0260749
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_796342.2
• Gene: Tmtc2 / 278279
• MGIID: 1914057
• Length: 836
• Species: Mus musculus
• Alignment Length: 347
• Identity: 74/347 - (21%)
• Similarity: 137/347 - (39%)
• Gaps: 54/347 - (15%)

  Fly   120 LGHLHLLLGEYSEALSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPN 184
            ||::.....:.|||.|||:..|.:|.|    ....:|.:|:...:...|..|:..::..:...|.
Mouse   499 LGNVLKSQSKISEAESAYRNALFYRSN----MADMLYNLGLLLQENSRFAEALHYYKLAIGSRPT 559

  Fly   185 FTCANEVHLRLGLMLKHCGEFHIA----LKHLQLA---LLYTYPSTFSELQVKFQIAHLYEVQNK 242
            ...|   :|..|::|.:.|:...|    ||..::.   |...:....|.....:.:..||..|.:
Mouse   560 LASA---YLNTGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGR 621

  Fly   243 HKAAKDGYEFLLNE--KNISLELKADVYRQLGWMY----------H-CVECLGEKKE-------- 286
            ::.|...|...:.:  ::.:.:   .:|..:|..|          | .:|.|..|.:
Mouse   622 YEEALSVYREAIQKMPRHFAPQ---SLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTY 683

  Fly   287 --------REANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTW 343
                    |::.|..|..|:||.||..|......|:.....:::.:|....:.:.|......|..
Mouse   684 GKLLALTGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDNTEFDVV 748

  Fly   344 CSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATK------ 402
            .:...:.:|.:....|.:.|..|.:|..::.||..|||.:....|:|:.|.|.||.|.:
Mouse   749 FNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDV 813

  Fly   403 --QISFQKSSLIRKKQAIRMKK 422
              |.:.:|...|.:||.::..|
Mouse   814 ITQSNLRKLWNIMEKQGLKTSK 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	4/33 (12%)
		LapB	171..444	CDD:442196	60/296 (20%)
		TPR repeat	186..216	CDD:276809	8/36 (22%)
		TPR repeat	228..255	CDD:276809	5/26 (19%)
		TPR repeat	265..300	CDD:276809	11/61 (18%)
		TPR repeat	307..334	CDD:276809	2/26 (8%)
		TPR repeat	339..369	CDD:276809	5/29 (17%)
		TPR repeat	374..402	CDD:276809	12/27 (44%)
		JmjC	870..978	CDD:396791
Tmtc2	NP_796342.2	ArnT	<78..>198	CDD:441412
		TMTC_DUF1736	247..321	CDD:462468
		TPR	488..707	CDD:440225	44/217 (20%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	493..526		11/30 (37%)
		TPR repeat	493..521	CDD:276809	8/21 (38%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	527..560		5/32 (16%)
		TPR repeat	527..555	CDD:276809	4/27 (15%)
		TPR repeat	560..590	CDD:276809	8/32 (25%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	561..594		8/35 (23%)
		TPR repeat	595..634	CDD:276809	7/38 (18%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	606..639		5/32 (16%)
		TPR	608..>812	CDD:440225	42/206 (20%)
		TPR repeat	642..671	CDD:276809	5/31 (16%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	643..676		7/35 (20%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	677..710		8/32 (25%)
		TPR repeat	679..705	CDD:276809	4/25 (16%)
		TPR repeat	710..774	CDD:276809	9/63 (14%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	711..744		4/32 (13%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	745..778		6/32 (19%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	779..812		12/32 (38%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)