DRSC/TRiP Functional Genomics Resources

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Protein Alignment Utx and IFIT5

DIOPT Version :9

Sequence 1:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster
Sequence 2:NP_036552.1 Gene:IFIT5 / 24138 HGNCID:13328 Length:482 Species:Homo sapiens


Alignment Length:479 Identity:96/479 - (20%)
Similarity:169/479 - (35%) Gaps:146/479 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 KNAIQKFEPSTQAGEHME--NTSSR----------------NNDDTKPFEQDAKEKVSIIEEKHQ 109
            |..|..||.....|:.:|  .|.||                |.|..:..|| |:|   ||:::|.
Human    26 KEDIDLFEVEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALECLEQ-AEE---IIQQEHS 86

  Fly   110 DEHYVNALCKLG-------HLHLL---------LGEYSEALSAYQKY-LRFRENNYWTNHAFIYG 157
            |:..|.:|...|       |:..|         :|...:.||:...| |...|.:.....|.:..
Human    87 DKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLKF 151

  Fly   158 IGVAYFKLRCFKWAIKSFQELLYLSP-----NFTCANEVHLRLGLMLKHCGEFHIALKHLQLALL 217
            .|..|.|.:.      :|::.|.:.|     |...|..|: ||....:.......:|..|:.|:.
Human   152 GGKYYQKAKA------AFEKALEVEPDNPEFNIGYAITVY-RLDDSDREGSVKSFSLGPLRKAVT 209

  Fly   218 YTYPSTFSE--LQVKFQIAHLYEVQNKHKAAKDGYEFL------LNEKNISLELKADVYRQLGWM 274
            ....:::.:  |.:|.|..|         |..:|.:::      ::.:...|...|..||     
Human   210 LNPDNSYIKVFLALKLQDVH---------AEAEGEKYIEEILDQISSQPYVLRYAAKFYR----- 260

  Fly   275 YHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCY---------------AGINK--- 321
                     :|.....||..|:|::|..|.|....:.:|.||               .|.:|   
Human   261 ---------RKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKV 316

  Fly   322 ---VHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDK---DHKAAWTNL 380
               :..|...::.::|:....|..:..:..:|.:..|.::|...:..|::|:.   |||..    
Human   317 DELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHKHQ---- 377

  Fly   381 GILYESCGQLRD--------AYACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITF 437
              ::...|:.::        |...||.|.|         ::.:..:|.|. |..|.|..::|:..
Human   378 --IHYHYGRFQEFHRKSENTAIHHYLEALK---------VKDRSPLRTKL-TSALKKLSTKRLCH 430

  Fly   438 ----------------LEGQLSQA 445
                            |||:..||
Human   431 NALDVQSLSALGFVYKLEGEKRQA 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 6/33 (18%)
TPR_11 156..216 CDD:290150 13/64 (20%)
TPR repeat 186..216 CDD:276809 6/29 (21%)
TPR repeat 228..255 CDD:276809 5/32 (16%)
TPR_11 264..337 CDD:290150 18/93 (19%)
TPR repeat 265..300 CDD:276809 8/34 (24%)
TPR repeat 307..334 CDD:276809 6/47 (13%)
TPR_11 339..402 CDD:290150 14/73 (19%)
TPR repeat 339..369 CDD:276809 5/29 (17%)
TPR_1 340..373 CDD:278916 6/35 (17%)
TPR repeat 374..402 CDD:276809 6/35 (17%)
JmjC 870..978 CDD:202224
IFIT5NP_036552.1 TPR_12 49..116 CDD:315987 17/70 (24%)
TPR 1 51..84 8/36 (22%)
TPR repeat 53..79 CDD:276809 5/26 (19%)
TPR repeat 84..133 CDD:276809 10/48 (21%)
TPR 2 94..127 5/32 (16%)
TPR 3 138..173 8/40 (20%)
TPR repeat 138..168 CDD:276809 6/35 (17%)
PEP_TPR_lipo <157..470 CDD:274350 63/344 (18%)
TPR 4 181..214 7/33 (21%)
TPR repeat 214..244 CDD:276809 6/38 (16%)
TPR 5 249..282 11/46 (24%)
TPR repeat 249..277 CDD:276809 9/41 (22%)
Interaction with the 5'-triphosphate group of PPP-RNA 254..260 1/5 (20%)
TPR repeat 282..333 CDD:276809 7/50 (14%)
TPR 6 338..371 6/32 (19%)
TPR repeat 338..366 CDD:276809 5/27 (19%)
TPR 7 376..410 6/48 (13%)
TPR repeat 376..405 CDD:276809 5/34 (15%)
TPR 8 435..468 5/20 (25%)
TPR repeat 435..463 CDD:276809 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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