DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and KDM6B

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001073893.1	Gene:	KDM6B / 23135	HGNCID:	29012	Length:	1682	Species:	Homo sapiens

Alignment Length:	740	Identity:	332/740 - (44%)
Similarity:	450/740 - (60%)	Gaps:	91/740 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 QKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQL-SQAPLPSITSKRRQLCSIEEAWNLPI-S 469
            ||......::..|..||::|...        .||:. ::|.:|...|:|       ...||.: |
Human   976 QKEHQKEHRRHRRACKDSVGRRP--------REGRAKAKAKVPKEKSRR-------VLGNLDLQS 1025

  Fly   470 LEMNSRQQQTAQMLPRQVTKQSPVQGPPPPYPHSQLSQ-----SPIPSKRIKEDGTSQQEVTQNN 529
            .|:..|::....:  ...:|..|...|.||...:..:|     :.:|.|:.:|:......|
Human  1026 EEIQGREKSRPDL--GGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGV---- 1084

  Fly   530 SQTSAQNLINISESLNQRNFNAMPESNK----SSEQSVLDTFDDISNDIYKQNESIKLERLSQDA 590
            |:.....|.::||        ..|:..|    ..|....:||  |::::.::...:....:|..|
Human  1085 SRADMLKLRSLSE--------GPPKELKIRLIKVESGDKETF--IASEVEERRLRMADLTISHCA 1139

  Fly   591 LSNNEDSRHDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPP 655
            ......||       ||.:...|:    ...|..|..:.|           ::|.         .
Human  1140 ADVVRASR-------NAKVKGKFR----ESYLSPAQSVKP-----------KINT---------E 1173

  Fly   656 QKLTRDQLLPPTPSVHLENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEAN 718
            :||.|::|.|||||::||:|:.||||.|.:||.  ::||.|:|||||.|:|:||||||||||||:
Human  1174 EKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEAS 1238

  Fly   719 PDHSVEVRTQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDK 783
            .:|:|||||||.|..|||||.:..:::|.|.|.||||||||||||||||||:||     |:|.:.
Human  1239 GEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESL-----QEEKES 1298

  Fly   784 GFPGSQAMSDSDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFAR 848
                    .|.:|::..|.:...........|..:::||||:||||.|:|||||.||.|||||.|
Human  1299 --------EDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMR 1355

  Fly   849 VISAANMLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGG 913
            |.|..||||||||.|||||||||||||||||||||||||||||:||||||||||||||.:.||..
Human  1356 VTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWET 1420

  Fly   914 VHNLCEKNNISYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNV 978
            :...|:::.:.||.|||||:|:|||..|||||||:|:||||||:|||.|||||:.||||||||||
Human  1421 ISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNV 1485

  Fly   979 GPLTARQYSLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHI 1043
            |||||.||.||:||||||:|:..||||||:|:|||:||.:|:||..||::||.||||::|:....
Human  1486 GPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQ 1550

  Fly  1044 QEYVKSKGVEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQG 1105
            :|.:...|.:|.:.||.|:|.::||.:|:|||||:||:..:   ...::|||..||.:.|..|||
Human  1551 RESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQG 1615

  Fly  1106 IVCLEEYRLSELQRVYDSFTLHRTQ 1130
            :|.||:||..||.:.||:|||.|.:
Human  1616 VVVLEQYRTEELAQAYDAFTLVRAR 1640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224	80/107 (75%)
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..680
		Mito_fiss_reg	<566..640	CDD:283069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..807
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..1096		29/140 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1325		10/49 (20%)
		JmjC	1343..1407	CDD:214721	55/63 (87%)
		JmjC	1377..1485	CDD:202224	80/107 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157954
Domainoid	1	1.000	184	1.000	Domainoid score	I3415
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm42304
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	O	PTHR14017
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.710