Protein Alignment Utx and KDM6B

DIOPT Version :10

• Sequence 1: NP_609368.3
• Gene: Utx / 34377
• FlyBaseID: FBgn0260749
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_001073893.1
• Gene: KDM6B / 23135
• HGNCID: 29012
• Length: 1682
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 332/740 - (44%)
• Similarity: 450/740 - (60%)
• Gaps: 91/740 - (12%)

  Fly   407 QKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQL-SQAPLPSITSKRRQLCSIEEAWNLPI-S 469
            ||......::..|..||::|...        .||:. ::|.:|...|:|       ...||.: |
Human   976 QKEHQKEHRRHRRACKDSVGRRP--------REGRAKAKAKVPKEKSRR-------VLGNLDLQS 1025

  Fly   470 LEMNSRQQQTAQMLPRQVTKQSPVQGPPPPYPHSQLSQ-----SPIPSKRIKEDGTSQQEVTQNN 529
            .|:..|::....:  ...:|..|...|.||...:..:|     :.:|.|:.:|:......|
Human  1026 EEIQGREKSRPDL--GGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGV---- 1084

  Fly   530 SQTSAQNLINISESLNQRNFNAMPESNK----SSEQSVLDTFDDISNDIYKQNESIKLERLSQDA 590
            |:.....|.::||        ..|:..|    ..|....:||  |::::.::...:....:|..|
Human  1085 SRADMLKLRSLSE--------GPPKELKIRLIKVESGDKETF--IASEVEERRLRMADLTISHCA 1139

  Fly   591 LSNNEDSRHDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPP 655
            ......||       ||.:...|:    ...|..|..:.|           ::|.         .
Human  1140 ADVVRASR-------NAKVKGKFR----ESYLSPAQSVKP-----------KINT---------E 1173

  Fly   656 QKLTRDQLLPPTPSVHLENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEAN 718
            :||.|::|.|||||::||:|:.||||.|.:||.  ::||.|:|||||.|:|:||||||||||||:
Human  1174 EKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEAS 1238

  Fly   719 PDHSVEVRTQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDK 783
            .:|:|||||||.|..|||||.:..:::|.|.|.||||||||||||||||||:||     |:|.:.
Human  1239 GEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESL-----QEEKES 1298

  Fly   784 GFPGSQAMSDSDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFAR 848
                    .|.:|::..|.:...........|..:::||||:||||.|:|||||.||.|||||.|
Human  1299 --------EDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMR 1355

  Fly   849 VISAANMLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGG 913
            |.|..||||||||.|||||||||||||||||||||||||||||:||||||||||||||.:.||..
Human  1356 VTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWET 1420

  Fly   914 VHNLCEKNNISYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNV 978
            :...|:::.:.||.|||||:|:|||..|||||||:|:||||||:|||.|||||:.||||||||||
Human  1421 ISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNV 1485

  Fly   979 GPLTARQYSLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHI 1043
            |||||.||.||:||||||:|:..||||||:|:|||:||.:|:||..||::||.||||::|:....
Human  1486 GPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQ 1550

  Fly  1044 QEYVKSKGVEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQG 1105
            :|.:...|.:|.:.||.|:|.::||.:|:|||||:||:..:   ...::|||..||.:.|..|||
Human  1551 RESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQG 1615

  Fly  1106 IVCLEEYRLSELQRVYDSFTLHRTQ 1130
            :|.||:||..||.:.||:|||.|.:
Human  1616 VVVLEQYRTEELAQAYDAFTLVRAR 1640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		LapB	171..444	CDD:442196	8/37 (22%)
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR repeat	339..369	CDD:276809
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:396791	80/107 (75%)
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..680
		PRK12323	<572..718	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1096		29/140 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1325		10/49 (20%)
		JmjC	1343..1407	CDD:214721	55/63 (87%)
		JmjC	1377..1485	CDD:396791	80/107 (75%)