DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Uty

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_017174175.1	Gene:	Uty / 22290	MGIID:	894810	Length:	1236	Species:	Mus musculus

Alignment Length:	1295	Identity:	541/1295 - (41%)
Similarity:	735/1295 - (56%)	Gaps:	274/1295 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTFEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQK 68
            ||.|:...:..|||.::|||..... .|:::.|:.:.|...::.|...   |.|..||
Mouse    36 LTVEEKKALCGLDSSFFGFLTRCKD-GAKMKTLLNKAIHFYESLIVKA---EGKVESD------- 89

  Fly    69 FEPSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEA 133
                                                           ..|:|||.:|||.:||:|
Mouse    90 -----------------------------------------------FFCQLGHFNLLLEDYSKA 107

  Fly   134 LSAYQKYLRFR-------ENNYW----------------TNHAFIYGIGVAYFKLRCFKWAIKSF 175
            ||:||:|...:       :|::|                .|.||:||:|:.||....|:|||::|
Mouse   108 LSSYQRYYSLQTDYWKAFQNHFWWWKITREVWKLLLRKFRNAAFLYGLGLVYFYYNAFQWAIRAF 172

  Fly   176 QELLYLSPNFTCANEVHLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQ 240
            ||:||:.|||..|.|:|||||.|.|...::..:|||.||||:.....|.|.::::|.||||||.|
Mouse   173 QEVLYVDPNFCRAKEIHLRLGFMFKMNTDYESSLKHFQLALIDCNVCTLSSVEIQFHIAHLYETQ 237

  Fly   241 NKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKS 305
            .|:.:||..||.||..:::..::||.|.:|||||:|.::.:|:...:|..|:.:||||:|.||.|
Mouse   238 RKYHSAKAAYEQLLQIESLPSQVKATVLQQLGWMHHNMDLIGDNTTKERYAIQYLQKSLEEDPNS 302

  Fly   306 GQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLD 370
            |||.|.|||||:.|.||.|||::||.|::|||.:|||||||||||||||||.|||||||||||||
Mouse   303 GQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 367

  Fly   371 KDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRI 435
            ..|.|||.:||||||||.|.:||..|||||.:..|...:|                   .|:.||
Mouse   368 HGHAAAWMDLGILYESCNQPQDAIKCYLNAARSKSCNNTS-------------------ALTSRI 413

  Fly   436 TFLEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQ------------------------ 476
            .||:.||...|..|:.:|.:.|.||||||:|||..|:.|||
Mouse   414 KFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQSVSDTWNSVQTASHHS 478

  Fly   477 -QQ-------TAQMLPRQVTKQSPVQGPPPPYPHSQLSQSPIPSKRIKEDGTSQQEVTQN----- 528
             ||       |||.|      ||..:...||:....       ::.::...|:.|....|
Mouse   479 VQQKVYTQCFTAQKL------QSFGKDQQPPFQTGS-------TRYLQAASTNDQNQNGNHTLPQ 530

  Fly   529 NSQTSAQN------------LINI--------SESLNQR-----------------------NFN 550
            ||:..|||            :||.        |:||..:                       ..:
Mouse   531 NSKGDAQNHFLRIPTSEEQKIINFTKESKDSRSKSLTSKTSRKDRDTSNICVNAKKHSNHIYQIS 595

  Fly   551 AMPESNKSSEQSVL----------------DTFDDISND-------------IYKQ--------- 577
            ::|.|:.::::||.                :|.|::.:|             |:|:
Mouse   596 SVPISSLNNKESVSPDLIIVDNPQLSVLVGETIDNVDHDIGTCDKVNNVHLAIHKKPDNLSASSP 660

  Fly   578 -----NESIKLERLSQDALSNNEDSRHDFI------GGDNADISTTFKIQMDSKQLMVAVKLLPI 631
                 .|::.|:...|..:..:..|.|..:      |.:|.:.|.:..:.:..:..::....:.|
Mouse   661 SSAISTETLSLKLTEQTHIVTSFISPHSGLHTINGEGHENLESSASVNVGLRPRSQIIPSMSVSI 725

  Fly   632 ----DEPPVHCTILQVN-----------APPPSPPDCPPQKLTRDQLLPPTPSVHLENKKHAFSP 681
                .|....|..|..|           .|||.||..|...|.:::|.|||||::||||:.||.|
Mouse   726 YSSSTEVLKACRSLGKNGLSNGHILLDICPPPRPPTSPYPPLPKEKLNPPTPSIYLENKRDAFFP 790

  Fly   682 QLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTSQGKR 744
            .|.:||:  |:|:.|:|||||.|||||||||||||||||.:|.||||||:.|..|||||.|..|:
Mouse   791 PLHQFCINPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHIVEVRTQLLQPADENWDPSGTKK 855

  Fly   745 VWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSKDSVSNSNIVLKR 809
            :|...:..|||||||||||||.|||:||:     :|:::   .:|....||::.:.|:::    .
Mouse   856 IWRYENKSSHTTIAKYAQYQACSFQESLR-----EENER---RTQVKDYSDNESTCSDNS----G 908

  Fly   810 KKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQLYMK 874
            ::.|...|.::.|.|:||||.||||.||.||.|||||.||:||.|:|||||:.|||||:|||.||
Mouse   909 RRQKAPFKTIKCGINIDLSDNKKWKLQLHELTKLPAFVRVVSAGNLLSHVGYTILGMNSVQLCMK 973

  Fly   875 VPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSWWPVLEDLYK 939
            |||||.|||||||||||:||||||||||||.||:.|||.:::.|||||:::|..||||.|||||:
Mouse   974 VPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYE 1038

  Fly   940 ENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEWNKVQAFKSI 1004
            .|:|||||||:||||||:|||.|||||:|||||||.||||||||.||.||:|||||||:|:.||:
Mouse  1039 ANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNVGPLTAFQYKLAVERYEWNKLQSVKSV 1103

  Fly  1005 VPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEASHYCG 1069
            |||||||||:||||||||.||||:||.|||:.||:...::|.:.:.|.|:.::||..:|.:.||.
Mouse  1104 VPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKHCQTLREALVAAGKEVLWHGRINDEPAPYCS 1168

  Fly  1070 QCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYDSFTL 1126
            .|||||||:||:..:   :|.::|||.:||.|.|.:|:..|.||:|::.:|.:|||.|||
Mouse  1169 ICEVEVFNLLFVTNESNSQKTYIVHCQNCARKTSGNLENFVVLEQYKMEDLIQVYDQFTL 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	17/49 (35%)
		TPR_11	156..216	CDD:290150	31/59 (53%)
		TPR repeat	186..216	CDD:276809	14/29 (48%)
		TPR repeat	228..255	CDD:276809	14/26 (54%)
		TPR_11	264..337	CDD:290150	39/72 (54%)
		TPR repeat	265..300	CDD:276809	15/34 (44%)
		TPR repeat	307..334	CDD:276809	17/26 (65%)
		TPR_11	339..402	CDD:290150	50/62 (81%)
		TPR repeat	339..369	CDD:276809	27/29 (93%)
		TPR_1	340..373	CDD:278916	30/32 (94%)
		TPR repeat	374..402	CDD:276809	19/27 (70%)
		JmjC	870..978	CDD:202224	82/107 (77%)
Uty	XP_017174175.1	TPR repeat	88..116	CDD:276809	17/81 (21%)
		TPR repeat	121..178	CDD:276809	18/56 (32%)
		TPR	130..397	CDD:223533	143/266 (54%)
		TPR repeat	183..213	CDD:276809	14/29 (48%)
		TPR repeat	224..252	CDD:276809	14/27 (52%)
		TPR repeat	262..297	CDD:276809	15/34 (44%)
		TPR repeat	304..331	CDD:276809	17/26 (65%)
		TPR repeat	336..366	CDD:276809	27/29 (93%)
		TPR repeat	371..399	CDD:276809	19/27 (70%)
		JmjC	935..999	CDD:214721	51/63 (81%)
		JmjC	969..1077	CDD:334913	82/107 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848341
Domainoid	1	1.000	507	1.000	Domainoid score	I333
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1043	1.000	Inparanoid score	I264
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49086
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm44356
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	O	PTHR14017
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770