DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Kdm6a

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_006527657.1	Gene:	Kdm6a / 22289	MGIID:	1095419	Length:	1476	Species:	Mus musculus

Alignment Length:	1494	Identity:	570/1494 - (38%)
Similarity:	738/1494 - (49%)	Gaps:	463/1494 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTFEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQK 68
            ||.|:...:..||||.:||:.. :...|.::.|:.:.:...::.|...   |.|..||
Mouse    43 LTAEEREALGGLDSRLFGFVRF-HEDGARMKALLGKAVRCYESLILKA---EGKVESD------- 96

  Fly    69 FEPSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEA 133
                                                           ..|:|||.:|||.:|.:|
Mouse    97 -----------------------------------------------FFCQLGHFNLLLEDYPKA 114

  Fly   134 LSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLM 198
            |||||:|... :::||.|.||:||:|:.||....|:||||:|||:||:.|:|..|.|:|||||||
Mouse   115 LSAYQRYYSL-QSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLM 178

  Fly   199 LKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLEL 263
            .|...::..:|||.||||:...|.|.|..:::|.||||||.|.|:.:||:.||.||..:|:|.::
Mouse   179 FKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQV 243

  Fly   264 KADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLA 328
            ||.:.:|||||:|.|:.||:|..:|:.|:.:||||:||||.||||.|.|||||:.|.||.|||::
Mouse   244 KATILQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFIS 308

  Fly   329 YRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDA 393
            ||.|::|||.:|||||||||||||||||.|||||||||||||..|.|||.:||.|||||.|.:||
Mouse   309 YRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDA 373

  Fly   394 YACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLC 458
            ..||||||:..:...:|                   ||:.||.:|:.||...|..|:.:|.:.|.
Mouse   374 IKCYLNATRSKNCSNTS-------------------GLAARIKYLQAQLCNLPQGSLQNKTKLLP 419

  Fly   459 SIEEAWNLPISLEMNSRQ----------------------------------------------- 476
            ||||||:|||..|:.|||
Mouse   420 SIEEAWSLPIPAELTSRQGAMNTAQQACKPHHPNTEPVLGLSQTPISQQSLPLHMIPPSQVDDLS 484

  Fly   477 -----------------------------QQT-------------------------AQML---- 483
                                         |||                         ||.|
Mouse   485 SPAKRKRTSSPTKNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQ 549

  Fly   484 ----------------------------------------------------------------- 483

Mouse   550 LESQFVLMQQHQMRQTGVAQVRPTGILNGPTVDSSLPTNSVSGQQPQLPLTRMPSVSQPGVHTAC 614

  Fly   484 PRQVTKQSP--------------------------------------VQGPPPPYPH-------- 502
            |||.....|                                      :|...|..||
Mouse   615 PRQTLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSS 679

  Fly   503 ------SQLSQS-------------------PI----PSKRIKEDGTSQQEVTQNNSQTSAQNLI 538
                  :|||.|                   |:    ||:.::..|:..|  .||...|...|.:
Mouse   680 TEEPWKNQLSNSTQGLHKGPSSHLAGPNGERPLSSTGPSQHLQAAGSGIQ--NQNGHPTLPSNSV 742

  Fly   539 NISESLN-----------QRNFNAMPESNKSSEQSVLDTFDDISNDIYKQNESIK-----LERLS 587
            ....:||           |:......||..|.....:......:.:......|::     :.::.
Mouse   743 TQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTVPETSRQTGETPNSTASVEGLPNHVHQVM 807

  Fly   588 QDAL---SNNEDSRHDFIGGDNADIS--------------------------------------- 610
            .||:   |:.:......:..||..:|
Mouse   808 ADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSVASSPS 872

  Fly   611 ----------------TTFKIQ----------------MDSKQLMVAVKLLPIDEPP-------- 635
                            ||..:.                |:..|..:...||.:...|
Mouse   873 SAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSM 937

  Fly   636 -----------------------VHCTILQVNAPPPSPPDCPPQKLTRDQLLPPTPSVHLENKKH 677
                                   .:.:||....|||.||..|...|.:|:|.|||||::||||:.
Mouse   938 SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRD 1002

  Fly   678 AFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTS 740
            ||.|.|.:||.  .:|:.|:|||||.|||||||||||||||||.:|.||||||:.|..|||||.:
Mouse  1003 AFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPT 1067

  Fly   741 QGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSKDSVSNSNI 805
            ..|::|.|.|:||||||||||||||||||:||:     :|::|   .|.....||| :|.|:.|
Mouse  1068 GTKKIWHCESNRSHTTIAKYAQYQASSFQESLR-----EENEK---RSHHKDHSDS-ESTSSDN- 1122

  Fly   806 VLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQ 870
              ..|:.|...|.::||||:||||:||||.||.||.|||||.||:||.|:||||||.||||||||
Mouse  1123 --SGKRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQ 1185

  Fly   871 LYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSWWPVLE 935
            |||||||||||||||||||||:||||||||||||.||:.|||.:::.|||||:::|.|||||.||
Mouse  1186 LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLE 1250

  Fly   936 DLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEWNKVQA 1000
            |||:.|:|||||||:||||||:|||.|||||:||||||||||||||||.||.||:|||||||:|.
Mouse  1251 DLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQN 1315

  Fly  1001 FKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEAS 1065
            .||||||||||||:||||||||.||||:||.|||:|||....::|.:.:.|.||.::||.|.|.:
Mouse  1316 VKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPA 1380

  Fly  1066 HYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYDSFTL 1126
            |||..||||||::||:..:   .|.::|||..||.|.|.:|:..|.||:|::.:|.:|||.|||
Mouse  1381 HYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTL 1444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	19/33 (58%)
		TPR_11	156..216	CDD:290150	32/59 (54%)
		TPR repeat	186..216	CDD:276809	15/29 (52%)
		TPR repeat	228..255	CDD:276809	14/26 (54%)
		TPR_11	264..337	CDD:290150	42/72 (58%)
		TPR repeat	265..300	CDD:276809	17/34 (50%)
		TPR repeat	307..334	CDD:276809	17/26 (65%)
		TPR_11	339..402	CDD:290150	49/62 (79%)
		TPR repeat	339..369	CDD:276809	27/29 (93%)
		TPR_1	340..373	CDD:278916	30/32 (94%)
		TPR repeat	374..402	CDD:276809	18/27 (67%)
		JmjC	870..978	CDD:202224	86/107 (80%)
Kdm6a	XP_006527657.1	TPR repeat	95..123	CDD:276809	17/81 (21%)
		TPR	108..401	CDD:223533	168/312 (54%)
		TPR repeat	131..161	CDD:276809	17/29 (59%)
		TPR repeat	166..196	CDD:276809	15/29 (52%)
		TPR repeat	207..235	CDD:276809	14/27 (52%)
		TPR repeat	287..314	CDD:276809	17/26 (65%)
		TPR repeat	319..349	CDD:276809	27/29 (93%)
		TPR repeat	354..380	CDD:276809	16/25 (64%)
		JmjC	1151..1215	CDD:214721	55/63 (87%)
		JmjC	1185..1293	CDD:334913	86/107 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848340
Domainoid	1	1.000	507	1.000	Domainoid score	I333
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7586
Inparanoid	1	1.050	1043	1.000	Inparanoid score	I264
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49086
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm44356
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	LDO	PTHR14017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R281
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800