DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Kdm6b

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_030101676.1	Gene:	Kdm6b / 216850	MGIID:	2448492	Length:	1642	Species:	Mus musculus

Alignment Length:	731	Identity:	331/731 - (45%)
Similarity:	450/731 - (61%)	Gaps:	89/731 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   413 RKKQAIRMK---KDTIGLSKGLSQRITFLEGQL-SQAPLPSITSKRRQLCSIEEAWNLPI-SLEM 472
            |:|:..|.:   :|::|...        .||:. ::|..|...|:|       ...||.: |.|:
Mouse   977 RQKEHRRHRRACRDSVGRRP--------REGRAKAKAKAPKEKSRR-------VLGNLDLQSEEI 1026

  Fly   473 NSRQQQTAQMLPRQVTKQSPVQGPPP-PYPHSQLS--QSPIPSKRIKEDGTSQQEVTQNNSQTSA 534
            ..|::....:......|......||| |.|.:|.:  .:|:|.|:.:|:......|    |:...
Mouse  1027 QGREKARPDVGGVSKVKTPTAPAPPPAPAPAAQPTPPSAPVPGKKTREEAPGPPGV----SRADM 1087

  Fly   535 QNLINISESLNQRNFNAMPESNK----SSEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNNE 595
            ..|.::||        ..|:..|    ..|....:||  |::::.::       ||....|:.:.
Mouse  1088 LKLRSLSE--------GPPKELKIRLIKVESGDKETF--IASEVEER-------RLRMADLTISH 1135

  Fly   596 DSRHDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPPQKLTR 660
            .:........||.:...|:    ...|..|..:.|           ::|.         .:||.|
Mouse  1136 CAADVMRASKNAKVKGKFR----ESYLSPAQSVKP-----------KINT---------EEKLPR 1176

  Fly   661 DQLLPPTPSVHLENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSV 723
            ::|.|||||::||:|:.||||.|.:||.  ::||.|:|||||.|:|:||||||||||||:.:|:|
Mouse  1177 EKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTV 1241

  Fly   724 EVRTQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGS 788
            ||||||.|..|||||.:..:::|.|.|.||||||||||||||||||:||:    |:|.:.
Mouse  1242 EVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQ----QEERES----- 1297

  Fly   789 QAMSDSDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAA 853
               .|.:|::..|.:...........|..:::||||:||||.|:|||||.||.|||||.||.|..
Mouse  1298 ---EDEESEEPDSTTGTSPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTG 1359

  Fly   854 NMLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLC 918
            ||||||||.|||||||||||||||||||||||||||||:||||||||||||||.:.||..:...|
Mouse  1360 NMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFC 1424

  Fly   919 EKNNISYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTA 983
            :::.:.||.|||||:|:|||..|||||||:|:||||||:|||.|||||:.|||||||||||||||
Mouse  1425 DRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTA 1489

  Fly   984 RQYSLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVK 1048
            .||.||:||||||:|:..||||||:|:|||:||.:|:||..||::||.||||::|:....:|.:.
Mouse  1490 YQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLV 1554

  Fly  1049 SKGVEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLE 1110
            ..|.:|.:.||.|:|.::||.:|:|||||:||:..:   ...::|||..||.:.|..|||:|.||
Mouse  1555 RAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLE 1619

  Fly  1111 EYRLSELQRVYDSFTL 1126
            :||..||.:.||:|||
Mouse  1620 QYRTEELAQAYDAFTL 1635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224	80/107 (75%)
Kdm6b	XP_030101676.1	TPR repeat	106..136	CDD:276809
		JmjC	1342..1406	CDD:214721	55/63 (87%)
		JmjC	1376..1484	CDD:396791	80/107 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848339
Domainoid	1	1.000	183	1.000	Domainoid score	I3423
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm44356
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	O	PTHR14017
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.700