DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and jmjd-3.2

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_510405.1	Gene:	jmjd-3.2 / 181543	WormBaseID:	WBGene00009089	Length:	867	Species:	Caenorhabditis elegans

Alignment Length:	772	Identity:	192/772 - (24%)
Similarity:	336/772 - (43%)	Gaps:	147/772 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 EEAWNLPISLEMNSRQQQTAQMLPRQ-----VTKQSPVQG-----------PPPPYPHSQLSQSP 509
            ||:....:.:..|.......|:||.|     ..::..:.|           ||....:|:|.:|.
Worm   131 EESGTDSLIVSTNDSGSTNEQILPTQSNDADFRERIEIDGRDQVDQHGNSYPPISGNNSKLRKSE 195

  Fly   510 I---------PSKRIKEDGTSQQEVTQNNSQTSAQ-------NLINISESLNQRNFNAM------ 552
            .         ||::.|.:...:   |::..:.||:       |...|.:..:..|.||.
Worm   196 SHEQGEFLVGPSRKRKPETLIE---TKSKKRKSARGRPSNKLNQFQIHQVSSDWNANAFLQFARR 257

  Fly   553 --------PESNKSSEQSVLDTFD------DISNDIYKQNESI-----KLERLSQDALSNNEDSR 598
                    .|..|.:..:.|:.|.      |:|..:.:.||::     ||..|:...:||..
Worm   258 DAAGTILESEEAKKTIDAQLEHFSEPSCSTDVSVHVVRDNENLGLVTNKLRSLAIPPISNLP--- 319

  Fly   599 HDFIGGDNADISTTFKIQ---------MD-----SKQLMV-AVKLLPIDEPPVH----CTIL--- 641
                    :|:.:.:|:.         ||     .||::. |.|.:...:..|:    |:.|
Worm   320 --------SDLPSLYKLPKLFLTGATFMDVSKSKGKQVITKASKWIKSGKNLVYETSGCSELFDE 376

  Fly   642 --QVNAPPPSPPDCPPQKLTRDQLLPPTPSVHLENKKHAFSPQLQEFCLKHPIAVVRGLAGVLKL 704
              :.|.......:...:...:||...|.|..::||.....|..::.......:.:.||:.....:
Worm   377 TTKFNTDGKIEENTSEEYTNKDQYRLPVPIYNIENNSDETSNFIKNIVNTTTMCIFRGIEEAFGM 441

  Fly   705 DLGLFSTKTLVEANPDHSVEVRTQVHQSPDENW---DTSQGKRV---WACISHRSHTTIAKYAQ- 762
            |...|...||....||:.:::|.|:.||...|:   |.:..:|:   ||.......|.:..:|:
Worm   442 DRQTFDISTLAPLYPDYPLKIRRQMPQSSATNFYMNDKNTVQRLGNAWAVFDFEGVTQLRDFAKN 506

  Fly   763 YQA------SSFQDSLKLILPQDESDKGFPGSQAMSDSDSKDSVSNSNIVLKRKKHKI----NSK 817
            |::      |::|..|:       :...|  |:.|  .|.|..:..:.|.|. .:||:    |:.
Worm   507 YESLKDIGRSAYQAILR-------NPSAF--SEVM--DDMKKQIKENTIPLS-PEHKLTVHENAT 559

  Fly   818 MLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQLYMKVPGSRTPG 882
            :|.||||:|| |::::|.||.|::|||...|...|.|:|:.....:.|:|..|:|.|.||:||..
Worm   560 VLAFGTNIDL-DDQRFKEQLDEIKKLPDCLRPDGAGNLLNFAQESLAGLNKPQVYCKPPGARTTA 623

  Fly   883 HQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSWWPVLEDLYKENIPVYRF 947
            |.||....|||||.|||||.|:.||..|.|.:..|.:|:.::.....:||..::|..|.||..:|
Worm   624 HLENQALGSININHGPGDCVWYGVPMEYSGRMEVLIKKHRLNVYKSGYWPSEQELRNEKIPSQKF 688

  Fly   948 IQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEWNKVQAFKSIVPMVHLSW 1012
            :|||||:|:|..|..|||||..:..|::|||...|..|.:.|:..::.|......:::|:..:.|
Worm   689 LQKPGDMVYVGIGTFHWVQSNDFAINVSWNVAQPTFNQLAAAMVIHDHNISSKATTLMPIEPIVW 753

  Fly  1013 NLARN-IKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEAS----HYCG--Q 1070
            .:|.: ::..|..:|...|..:|::|.......::...:.:.||   ..|||.|    ..|.  :
Worm   754 KMAEDGVEAEDENIFLARKAIMLKSLAKSQFEFDFAIQENMLIR---SAKNEKSIIPVERCSIQK 815

  Fly  1071 CEVEVFNVLFIKEQEKRHVVHCLSCALKLSPSLQGIV---CLEEYRLSELQRVYDSF 1124
            |...:||::.:..::.   ..||:|.:|      |.|   ..:...:::|.:::|.|
Worm   816 CREVLFNMITLDNKQN---PFCLNCIVK------GKVKATAFQRRDIADLVKIFDEF 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224	49/107 (46%)
jmjd-3.2	NP_510405.1	COG5644	40..>191	CDD:227931	11/59 (19%)
		JmjC	577..641	CDD:214721	29/63 (46%)
		JmjC	611..719	CDD:334913	49/107 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14017
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880