DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and utx-1

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001309685.1	Gene:	utx-1 / 181110	WormBaseID:	WBGene00017046	Length:	1146	Species:	Caenorhabditis elegans

Alignment Length:	1212	Identity:	393/1212 - (32%)
Similarity:	618/1212 - (50%)	Gaps:	204/1212 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DSRYYG----FLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQKFEPSTQAG 76
            :.|:.|    :|:|....|.||..:  :|:::|    :..:.| .:|.:|....::.|  ..:|.
Worm    19 EERHPGNFKKWLELPLLTNYELERI--RTLSSL----SFDEFH-VQNPADLTYQVRLF--FAKAR 74

  Fly    77 EHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYL 141
            :::    .|..|:.|...:..|.|.  ||.:     ....|.|..|:.||..:::.||..||:.|
Worm    75 QYL----VRYVDEMKSIYKTHKYKT--IERR-----IFYGLAKQCHVVLLANDWTGALELYQEVL 128

  Fly   142 RFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKHCGEFH 206
            ....:.:..:.:..:|:|:.|...:.:|.||::|..|||..|....|.:..:|||:......:::
Worm   129 SHHPDLFSHDPSMYFGLGLVYLHFKQWKPAIEAFTRLLYSFPTGMIALQAKVRLGVCYMELEDYN 193

  Fly   207 IALKHLQLALLYTYPSTF-SELQVKFQIAHLYEVQNKHKAAKDGYE-----------FLLNEKNI 259
            ..:...:||:..:..|.| .:..:|:.||..:|..::.:.|:..||           ||.::.|:
Worm   194 RCINLFKLAVNDSDESVFMPKFTIKYNIALSHENNDELEIAESEYENLITELTQHISFLQSKSNV 258

  Fly   260 S-------LELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIE-------ADPKSGQSLY 310
            .       :.:||...||:||:.:     ....:.:||.|:.|:|:.|       .||:.|||.|
Worm   259 DQQQVDLLISVKAACLRQIGWISY-----RRSYKDDANRLDHLKKAQENLISAHDTDPRDGQSYY 318

  Fly   311 LLGRCY-------AGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQ 368
            .|||.|       :| ...||||:.||.|::|.|.|||||||||.|||:||||.|||||:|||::
Worm   319 YLGRVYGEHEPSVSG-QVAHDAFVNYRFSIDKKEQNADTWCSIGALYQRQNQPIDALQAFICAIE 382

  Fly   369 LDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQ 433
            |:..|.||||:||.|||...|.:||..|:.||                   |..:.:. .:.:..
Worm   383 LNSTHSAAWTDLGELYEKNAQYQDALECFKNA-------------------MLNNPVA-PEPIKA 427

  Fly   434 RITFLEGQLSQAPLPSITSKRRQ-------LCSIEEAWNLPISLEMNSRQQQTAQMLPRQVTKQS 491
            |:.|||.:||. |:|:..|....       :.|::||:..||.||:.:||.  |....|:....:
Worm   428 RVQFLEKELSM-PVPARPSNHASSSTFETVIPSLKEAYEQPIPLELRNRQD--AAYADREAQYDN 489

  Fly   492 ----------PVQGPPP---------PYPHSQLSQSPIPSKRIKEDG--TSQQEVTQNNSQTSAQ 535
                      .::...|         |.|...|....:...|..|..  .:::||.:....:.|.
Worm   490 AFWDLWEDFRTMEHEKPEDMEWDVTYPRPMEDLEIQVMQLLRANEPALVKAEREVLECLETSEAV 554

  Fly   536 NLINISESLNQRNFNAMPESNKSSEQSVLD-------------------TFDDISNDIYKQNESI 581
            ....:.|.:.......||...:...|::.|                   :|:|:.       :|.
Worm   555 FKAKVIEYVIPEAVREMPRVTEEMIQNLRDHGHLLESPRCYSFPFLPKISFNDLP-------DSF 612

  Fly   582 KLERLSQDALSNNEDSRHDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAP 646
            .|  ||:..:|              .|||....:||..::.......||:.|.         .|.
Worm   613 SL--LSELYVS--------------MDISAQEIMQMVHRRTQPNSTYLPVFEE---------FAK 652

  Fly   647 PPSPPDCPPQKLTRDQ-------------LLPPTPSVHLENKKHAFSPQLQEFCLKHPIAVVRGL 698
            .|.||..|.:.:..|:             |:..||.:.::|:|.|.|.:||.|.....|:.:|||
Worm   653 LPEPPRGPVKPIVTDEDVRTALERSEKHPLILKTPILTVDNRKEAQSLELQRFLDGSTISCIRGL 717

  Fly   699 AGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQY 763
            .|.|:|||.|||||.:.|.:.:..:|:|||....|:.|.|.: .::.|.|:|..|:||:.|||:|
Worm   718 TGCLRLDLSLFSTKAVAEIDGNQEIEIRTQYQLPPETNCDHA-SQQTWQCVSDPSYTTVNKYAEY 781

  Fly   764 QASSFQDSLKLILPQDESD---KGFPGSQAMSDSDSKDSVSNSNIVLKR----KKHKINSKMLRF 821
            |:.||:.:||     .|::   |...|::..|....|        :.||    .||   .|.:::
Worm   782 QSESFKHTLK-----GEAEKIKKNVGGTRGPSPKRMK--------LYKRASSPPKH---LKSIKY 830

  Fly   822 GTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQLYMKVPGSRTPGHQEN 886
            |||:||||:.||..|:.||.|||||.|:|:.:|||||:||.:.|||||:|:|||||.|||.||::
Worm   831 GTNIDLSDDTKWGKQINELSKLPAFCRLIAGSNMLSHLGHQVHGMNTVKLFMKVPGCRTPAHQDS 895

  Fly   887 NNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSWWPVLEDLYKENIPVYRFIQKP 951
            |:..|||||||||||||||||..|||.:|.|||||.:..|.|::||:::||....|||:||.||.
Worm   896 NHMASININIGPGDCEWFAVPYEYWGKMHKLCEKNGVDLLTGTFWPIIDDLLDAGIPVHRFTQKA 960

  Fly   952 GDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEWNKVQAFKSIVPMVHLSWNLAR 1016
            ||:|:|:.|.:||||:.||||||:|||.||..:|.|:::..||:||::.|||.|||..:.|.:|:
Worm   961 GDMVYVSGGAIHWVQASGWCNNISWNVAPLNFQQLSISLLSYEYNKLRRFKSEVPMQLMCWQVAK 1025

  Fly  1017 NIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEASHYCGQCEVEVFNVLFI 1081
            |:|.::..::...|..|:::|..:..:.:|:.|:...|:.:.|...|.||:|..||.|||.:||:
Worm  1026 NVKFTNQLIYNTCKGVLIRSLAFLRMVADYIVSQKKTIKAHTRTSGEQSHFCMTCECEVFCILFV 1090

  Fly  1082 KEQEKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYDS 1123
            |:...:..|.|:.||  .|..::|.:.|:::..::|..:||:
Worm  1091 KDIGGKFTVFCVYCA--KSQGIEGFIALQQFSFTDLYSIYDN 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	9/33 (27%)
		TPR_11	156..216	CDD:290150	16/59 (27%)
		TPR repeat	186..216	CDD:276809	5/29 (17%)
		TPR repeat	228..255	CDD:276809	9/37 (24%)
		TPR_11	264..337	CDD:290150	31/86 (36%)
		TPR repeat	265..300	CDD:276809	10/34 (29%)
		TPR repeat	307..334	CDD:276809	15/33 (45%)
		TPR_11	339..402	CDD:290150	41/62 (66%)
		TPR repeat	339..369	CDD:276809	24/29 (83%)
		TPR_1	340..373	CDD:278916	24/32 (75%)
		TPR repeat	374..402	CDD:276809	15/27 (56%)
		JmjC	870..978	CDD:202224	67/107 (63%)
utx-1	NP_001309685.1	TPR_11	138..204	CDD:290150	17/65 (26%)
		TPR repeat	138..168	CDD:276809	9/29 (31%)
		TPR repeat	176..203	CDD:276809	4/26 (15%)
		TPR repeat	271..301	CDD:276809	10/34 (29%)
		TPR repeat	315..348	CDD:276809	15/33 (45%)
		TPR_11	353..419	CDD:290150	42/84 (50%)
		TPR repeat	353..383	CDD:276809	24/29 (83%)
		TPR_1	354..387	CDD:278916	24/32 (75%)
		TPR repeat	388..415	CDD:276809	15/45 (33%)
		TPR	390..419	CDD:197478	15/47 (32%)
		JmjC	845..909	CDD:214721	42/63 (67%)
		JmjC	879..987	CDD:202224	67/107 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159861
Domainoid	1	1.000	279	1.000	Domainoid score	I893
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7586
Inparanoid	1	1.050	576	1.000	Inparanoid score	I555
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49086
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		oto20141
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	LDO	PTHR14017
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770