DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and TMTC2

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_689801.1	Gene:	TMTC2 / 160335	HGNCID:	25440	Length:	836	Species:	Homo sapiens

Alignment Length:	345	Identity:	74/345 - (21%)
Similarity:	131/345 - (37%)	Gaps:	50/345 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LGHLHLLLGEYSEALSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPN 184
            ||::.....:.|||.|||:..|.:|.|    ....:|.:|:...:...|..|:..::..:...|.
Human   499 LGNVLKSQSKISEAESAYRNALYYRSN----MADMLYNLGLLLQENSRFAEALHYYKLAIGSRPT 559

  Fly   185 FTCANEVHLRLGLMLKHCGEFHIA----LKHLQLA---LLYTYPSTFSELQVKFQIAHLYEVQNK 242
            ...|   :|..|::|.:.|....|    ||..::.   |...:....|.....:.:..||..|..
Human   560 LASA---YLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH 621

  Fly   243 HKAAKDGYEFLLNEKNISLELKADVYRQLGWMY----------H-CVECLGEKKE---------- 286
            ::.|...|:..: :|.........:|..:|..|          | .:|.|..|.:
Human   622 YEEALSVYKEAI-QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGK 685

  Fly   287 ------REANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCS 345
                  |::.|.....|:||.||..|......|:......::.:|....:.:.|......|...:
Human   686 LLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFN 750

  Fly   346 IGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATK-------- 402
            ...:.:|.:....|.:.|..|.:|..::.||..|||.:....|:|:.|.|.||.|.:
Human   751 AAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVIT 815

  Fly   403 QISFQKSSLIRKKQAIRMKK 422
            |.:.:|...|.:||.::..|
Human   816 QSNLRKLWNIMEKQGLKTSK 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	4/33 (12%)
		TPR_11	156..216	CDD:290150	13/66 (20%)
		TPR repeat	186..216	CDD:276809	8/36 (22%)
		TPR repeat	228..255	CDD:276809	5/26 (19%)
		TPR_11	264..337	CDD:290150	18/99 (18%)
		TPR repeat	265..300	CDD:276809	10/61 (16%)
		TPR repeat	307..334	CDD:276809	2/26 (8%)
		TPR_11	339..402	CDD:290150	18/62 (29%)
		TPR repeat	339..369	CDD:276809	5/29 (17%)
		TPR_1	340..373	CDD:278916	6/32 (19%)
		TPR repeat	374..402	CDD:276809	12/27 (44%)
		JmjC	870..978	CDD:202224
TMTC2	NP_689801.1	DUF1736	247..318	CDD:285594
		TPR 1	462..492
		TPR_11	493..554	CDD:290150	15/58 (26%)
		TPR 2	493..526		11/30 (37%)
		TPR repeat	493..521	CDD:276809	8/21 (38%)
		TPR_1	493..>520	CDD:278916	8/20 (40%)
		TPR 3	527..560		5/32 (16%)
		TPR repeat	527..555	CDD:276809	4/27 (15%)
		TPR_12	557..634	CDD:290160	16/80 (20%)
		TPR repeat	560..590	CDD:276809	8/32 (25%)
		TPR 4	562..594		8/34 (24%)
		TPR repeat	595..634	CDD:276809	7/39 (18%)
		TPR 5	606..639		6/33 (18%)
		TPR_2	609..638	CDD:285020	6/29 (21%)
		TPR repeat	642..671	CDD:276809	5/28 (18%)
		TPR 6	643..676		7/32 (22%)
		TPR_11	645..708	CDD:290150	12/62 (19%)
		TPR 7	677..710		7/32 (22%)
		TPR repeat	679..705	CDD:276809	3/25 (12%)
		TPR repeat	710..774	CDD:276809	9/63 (14%)
		TPR 8	712..744		3/31 (10%)
		TPR 9	746..778		6/31 (19%)
		TPR_19	755..822	CDD:291240	18/66 (27%)
		TPR 10	779..812		12/32 (38%)
		TPR_1	779..812	CDD:278916	12/32 (38%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900