DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and TTC32

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001008238.1	Gene:	TTC32 / 130502	HGNCID:	32954	Length:	151	Species:	Homo sapiens

Alignment Length:	176	Identity:	40/176 - (22%)
Similarity:	63/176 - (35%)	Gaps:	57/176 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 IEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYLR----------------------FREN 146
            :|.:.|:.|   |...|...|...|||:||.:.|..|:|                      ...|
Human     1 MEGQRQESH---ATLTLAQAHFNNGEYAEAEALYSAYIRRCACAASSDESPGSKCSPEDLATAYN 62

  Fly   147 NYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEV-HLRLGLMLKHCGEFHIALK 210
            |...         :.||::..:: |:..:...:.:.|||    || :...||:|...|.|..||:
Human    63 NRGQ---------IKYFRVDFYE-AMDDYTSAIEVQPNF----EVPYYNRGLILYRLGYFDDALE 113

  Fly   211 HLQLALLYTYPSTFSELQVKFQIAHL--------YEVQNKHKAAKD 248
            ..:..|         :|...||.|.|        .|.:.:...||:
Human   114 DFKKVL---------DLNPGFQDATLSLKQTILDKEEKQRRNVAKN 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	4/33 (12%)
		TPR_11	156..216	CDD:290150	15/60 (25%)
		TPR repeat	186..216	CDD:276809	9/30 (30%)
		TPR repeat	228..255	CDD:276809	7/29 (24%)
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224
TTC32	NP_001008238.1	TPR_11	2..>143	CDD:330823	38/166 (23%)
		TPR 1	8..41		12/35 (34%)
		PLN03088	<55..>123	CDD:330826	19/90 (21%)
		TPR repeat	57..87	CDD:276809	5/39 (13%)
		TPR 2	58..91		6/42 (14%)
		TPR 3	92..125		11/41 (27%)
		TPR repeat	92..120	CDD:276809	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900