DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and Ogt

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_631883.2	Gene:	Ogt / 108155	MGIID:	1339639	Length:	1046	Species:	Mus musculus

Alignment Length:	545	Identity:	117/545 - (21%)
Similarity:	197/545 - (36%)	Gaps:	123/545 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RELDSRYYGFLDLSNSKNAELRNLVQQTITNLQN-YIANGQVHESKNSSDNKNAIQKFEPSTQAG 76
            |.|| |...|..|:..:|.    |:.:..:||.| |...||:.|                   |.
Mouse    69 RRLD-RSAHFSTLAIKQNP----LLAEAYSNLGNVYKERGQLQE-------------------AI 109

  Fly    77 EHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNAL-------C---KLGHLHLLLGEYS 131
            ||..:......|....:...|...|:..:.:...:.||:||       |   .||:|...||...
Mouse   110 EHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLE 174

  Fly   132 EALSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRC-FK-----W-AIKSFQELLYLSPNFTCAN 189
            ||.:.|.|.:..:.|           ..||:..|.| |.     | ||..|::.:.|.|||.
Mouse   175 EAKACYLKAIETQPN-----------FAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFL--- 225

  Fly   190 EVHLRLGLMLKHCGEF---------------HIALKHLQLALLY-----------TYPSTFSELQ 228
            :.::.||.:||....|               :.|:.|..||.:|           ||.... |||
Mouse   226 DAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAI-ELQ 289

  Fly   229 VKF-----QIAHLYEVQNKHKAAKDGYEFLLNEKNISLEL---KADVYRQLGWMYHCVECLGEKK 285
            ..|     .:|:..:.:.....|:|.|       |.:|.|   .||          .:..|...|
Mouse   290 PHFPDAYCNLANALKEKGSVAEAEDCY-------NTALRLCPTHAD----------SLNNLANIK 337

  Fly   286 EREAN---ALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIG 347
            ..:.|   |:...:|::|..|:...:...|........|:.:|.:.|:.::..|...||.:.::|
Mouse   338 REQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMG 402

  Fly   348 VLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQKSSLI 412
            ...::......|||.|..|:|::.....|.:||..:::..|.:.:|.|.|..|.|.......:..
Mouse   403 NTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYC 467

  Fly   413 RKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQQ 477
            .....:::..|.....:.:.:.::.:..||.:..|||:......|..:...:...|:....:...
Mouse   468 NLAHCLQIVCDWTDYDERMKKLVSIVAEQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCL 532

  Fly   478 QTAQMLPRQVTKQSPVQGPPPPYPH 502
            ....:|.:            |||.|
Mouse   533 DKINVLHK------------PPYEH 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	9/40 (23%)
		TPR_11	156..216	CDD:290150	21/81 (26%)
		TPR repeat	186..216	CDD:276809	8/44 (18%)
		TPR repeat	228..255	CDD:276809	6/31 (19%)
		TPR_11	264..337	CDD:290150	13/75 (17%)
		TPR repeat	265..300	CDD:276809	7/37 (19%)
		TPR repeat	307..334	CDD:276809	4/26 (15%)
		TPR_11	339..402	CDD:290150	17/62 (27%)
		TPR repeat	339..369	CDD:276809	8/29 (28%)
		TPR_1	340..373	CDD:278916	9/32 (28%)
		TPR repeat	374..402	CDD:276809	8/27 (30%)
		JmjC	870..978	CDD:202224
Ogt	NP_631883.2	TPR 1	21..54
		PEP_TPR_lipo	<22..>465	CDD:274350	104/451 (23%)
		TPR repeat	24..49	CDD:276809
		TPR repeat	57..83	CDD:276809	6/14 (43%)
		TPR 2	89..122		10/51 (20%)
		TPR repeat	89..117	CDD:276809	10/46 (22%)
		TPR repeat	122..152	CDD:276809	6/29 (21%)
		TPR 3	123..156		6/32 (19%)
		TPR 4	157..190		11/43 (26%)
		TPR repeat	157..185	CDD:276809	10/27 (37%)
		TPR 5	191..224		11/32 (34%)
		TPR repeat	191..219	CDD:276809	9/27 (33%)
		TPR 6	225..258		5/35 (14%)
		TPR repeat	226..253	CDD:276809	5/26 (19%)
		TPR 7	259..292		10/33 (30%)
		TPR repeat	259..287	CDD:276809	7/28 (25%)
		TPR 8	293..326		7/39 (18%)
		TPR repeat	293..321	CDD:276809	5/34 (15%)
		TPR 9	327..360		9/42 (21%)
		TPR repeat	327..355	CDD:276809	7/37 (19%)
		TPR repeat	360..390	CDD:276809	4/29 (14%)
		TPR 10	361..394		5/32 (16%)
		TPR 11	395..428		9/32 (28%)
		TPR repeat	395..423	CDD:276809	8/27 (30%)
		TPR 12	429..462		9/32 (28%)
		TPR repeat	429..457	CDD:276809	8/27 (30%)
		TPR 13, truncated	463..473		0/9 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	487..503		2/15 (13%)
		Glyco_transf_41	556..1024	CDD:372753
		Required for phosphatidylinositol 3,4,5-triphosphate binding	991..1010
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900