DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Uty

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_008771917.2	Gene:	Uty / 100310845	RGDID:	1565481	Length:	1251	Species:	Rattus norvegicus

Alignment Length:	1311	Identity:	545/1311 - (41%)
Similarity:	721/1311 - (54%)	Gaps:	291/1311 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTFEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQK 68
            ||.|:...:..|||.::|||.|... ..:::.|:.:.|...::.|...   |.|..||
  Rat    36 LTVEEKKALCGLDSSFFGFLSLCKD-GVKMKTLLNKAIHCYESLIVKA---EGKVESD------- 89

  Fly    69 FEPSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEA 133
                                                           ..|:|||.:|||.:||:|
  Rat    90 -----------------------------------------------FFCQLGHFNLLLEDYSKA 107

  Fly   134 LSAYQKYLRFRENNYW---------------TNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSP 183
            ||:||:|... :.:||               ||.||:||:|:.||....|:|||::|||:||:.|
  Rat   108 LSSYQRYYSL-QTDYWKLWLVCKLRFQQKRDTNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDP 171

  Fly   184 NFTCANEVHLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQN------- 241
            ||..|.|:|||||.|.|...::..:|||.||||..:...|.|.::::|.||||:|:||
  Rat   172 NFCRAKEIHLRLGFMFKVNTDYESSLKHFQLALRDSNVCTLSSVEIQFHIAHLFEIQNGMARNSW 236

  Fly   242 -----------KHKAAKDGYEFLLNEK--NISLELKADVY--RQL---GWMYHCVECLGEKKERE 288
                       ||   :|....:|.::  |...:|||..:  :||   .||:|.::.:|:...:|
  Rat   237 CSKDICFMVIRKH---RDRGNTILQKQPMNNFYKLKAFHHKSKQLYCNSWMHHNMDLVGDNTTKE 298

  Fly   289 ANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQ 353
            ..|:.:||||:|.||.||||.|.|||||:.|.||.|||::||.|::|||.:||||||||||||||
  Rat   299 RYAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQ 363

  Fly   354 NQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQKSSLIRKKQAI 418
            |||.|||||||||||||..|.|||.:||||||||.|.:||..||||||:..|...:|:
  Rat   364 NQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKSCSNTSV------- 421

  Fly   419 RMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQ--QQTAQ 481
                        |..||.||:.||...|..|:.:|.:.|.||||||:|||..|:.|||  ..|||
  Rat   422 ------------LISRIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQ 474

  Fly   482 MLPR------QVTKQSPVQGPPPPYPHSQLSQSPIPSKRIKEDGTSQQ----------------- 523
            ....      ......|||        .|:......:::::..|..||
  Rat   475 QNVSDSWNSVHTASHHPVQ--------QQVYTQCFTTQKLQGLGKDQQRPFQTGSTRYIHAACVD 531

  Fly   524 EVTQNNSQTSAQN---------LINISESLNQRNFNAMPESNKSSEQSV---LDTFDDISNDIY- 575
            ...||.:.|..||         .::|..|..|:.||...||..|..:|:   ....|..:::||
  Rat   532 NQNQNGNHTLPQNSKGDTQNHSSLHIPTSEEQKIFNFTKESKDSRSKSLSPKTSRQDRDTSNIYV 596

  Fly   576 -KQNESIKLERLSQDALS--NNEDS-RHDFIGGDNADISTTFKIQMDS----------------- 619
             .:..|..:..::...:|  ||||| ..:.|..||..:|......|||
  Rat   597 NAKEHSKNIHEITSVPISSLNNEDSVSPNLIIVDNPQLSVLVGEAMDSVDHDSRTCDKVNNVHPT 661

  Fly   620 --------------------------------------------------------KQLMVAVKL 628
                                                                    ..:.|:|.|
  Rat   662 LHKKPDNLTASSPSSASSTETLSLKVTEQMHTHIVTSFISPNSGLDTINGGPENSESSISVSVGL 726

  Fly   629 LPIDEPPV-----------------HCTILQVN-----------APPPSPPDCPPQKLTRDQLLP 665
            .|  .|.:                 .|..|..|           .|||.||..|...|.:::|.|
  Rat   727 RP--RPQIIPSMSVSIYSSSTEVLKACRNLGKNGLSNGHILLDICPPPRPPTSPYPPLPKEKLNP 789

  Fly   666 PTPSVHLENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQ 728
            ||||::||||:.||.|.|.:||:  |:|:.|:|||||.|||||||||||||||||.:|.||||||
  Rat   790 PTPSIYLENKRDAFFPPLHQFCINPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHIVEVRTQ 854

  Fly   729 VHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSD 793
            ..|..|||||.|..|::|...:..|||||||||||||.|||:||:     :|:::   .:|....
  Rat   855 FLQPADENWDPSGTKKIWRYENKSSHTTIAKYAQYQACSFQESLR-----EENER---KTQVKDY 911

  Fly   794 SDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSH 858
            ||::.:.|:    :.|::.|:..|.::.|.|:||||.||||.||.||.|||||.||:||.|:|||
  Rat   912 SDNESTCSD----ISRRRQKVPFKTIKCGINIDLSDNKKWKLQLHELTKLPAFVRVVSAGNLLSH 972

  Fly   859 VGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNI 923
            ||:.|||||:|||.|||||||.|||||||||||:||||||||||||.||:.|||.:::.|||||:
  Rat   973 VGYTILGMNSVQLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNL 1037

  Fly   924 SYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSL 988
            ::|..||||.|||||:.|:|||||||:||||||:|||.|||||:|||||||.||||||||.||.|
  Rat  1038 NFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNVGPLTAFQYKL 1102

  Fly   989 AIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVE 1053
            |:|||||||:|:.||:|||||||||:||||||||.||||:||.|||:.||....::|.:.:.|.|
  Rat  1103 AVERYEWNKLQSIKSVVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQCQTLREALVAAGKE 1167

  Fly  1054 IRFNGRGKNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLS 1115
            :.::||..:|.:.||..|||||||:||:..:   :|.::|||.:||.|.|.:|:..|.||:|::.
  Rat  1168 VLWHGRINDEPAPYCSICEVEVFNLLFVTNESNSQKTYIVHCQNCARKTSGNLENFVVLEQYKME 1232

  Fly  1116 ELQRVYDSFTL 1126
            :|.:|||.|||
  Rat  1233 DLIQVYDQFTL 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	19/48 (40%)
		TPR_11	156..216	CDD:290150	31/59 (53%)
		TPR repeat	186..216	CDD:276809	14/29 (48%)
		TPR repeat	228..255	CDD:276809	11/44 (25%)
		TPR_11	264..337	CDD:290150	37/77 (48%)
		TPR repeat	265..300	CDD:276809	13/39 (33%)
		TPR repeat	307..334	CDD:276809	17/26 (65%)
		TPR_11	339..402	CDD:290150	50/62 (81%)
		TPR repeat	339..369	CDD:276809	27/29 (93%)
		TPR_1	340..373	CDD:278916	30/32 (94%)
		TPR repeat	374..402	CDD:276809	19/27 (70%)
		JmjC	870..978	CDD:202224	82/107 (77%)
Uty	XP_008771917.2	TPR repeat	88..116	CDD:276809	17/81 (21%)
		TPR repeat	121..169	CDD:276809	19/47 (40%)
		TPR	140..173	CDD:197478	17/32 (53%)
		TPR repeat	174..205	CDD:276809	15/30 (50%)
		TPR	175..410	CDD:223533	119/237 (50%)
		TPR repeat	317..344	CDD:276809	17/26 (65%)
		TPR repeat	349..379	CDD:276809	27/29 (93%)
		TPR repeat	384..410	CDD:276809	17/25 (68%)
		JmjC	950..1014	CDD:214721	51/63 (81%)
		JmjC	984..1092	CDD:396791	82/107 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7586
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010