DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and kdm6a

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_012811996.1	Gene:	kdm6a / 100170558	XenbaseID:	XB-GENE-960316	Length:	1455	Species:	Xenopus tropicalis

Alignment Length:	1500	Identity:	581/1500 - (38%)
Similarity:	749/1500 - (49%)	Gaps:	473/1500 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTFEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQK 68
            ||.|:...:..||||.||||.| :...|..:.|:.:.|...:..|...   |.|..||
Frog    43 LTAEEREALVGLDSRLYGFLRL-HEDGARTKALLLKAIRCYEALILKS---EGKVESD------- 96

  Fly    69 FEPSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEA 133
                                                           ..|:|||.:|||.:|.:|
Frog    97 -----------------------------------------------FFCQLGHFNLLLEDYPKA 114

  Fly   134 LSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLM 198
            |||||:|... :::||.|.||:||:|:.||....|.|||::|||:||:.|:|..|.|:|||||||
Frog   115 LSAYQRYYSL-QSDYWKNAAFLYGLGLVYFHYNAFHWAIRAFQEVLYVEPSFCRAKEIHLRLGLM 178

  Fly   199 LKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLEL 263
            .|...::..:|||.||||:...|.|.|:.:::|.||||||.|.|:.:||:.||.||..:|:..::
Frog   179 FKVNTDYESSLKHFQLALIDCNPCTLSKAEIQFHIAHLYETQKKYHSAKEAYEQLLQTENLPTQV 243

  Fly   264 KADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLA 328
            ||.|.:|||||:|.|:.||:|..:.:.|:.:||||:||||.||||.|.|||||:.|.||.|||::
Frog   244 KATVLQQLGWMHHTVDQLGDKATKASYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFIS 308

  Fly   329 YRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDA 393
            ||.|::|||.:|||||||||||||||||.|||||||||||||..|.|||.:||.|||||.|.:||
Frog   309 YRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDA 373

  Fly   394 YACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLC 458
            ..||||||:..:...:|                   .|:.||.:|:.||...|..|:.:|.:.|.
Frog   374 IKCYLNATRSKNCNNTS-------------------ALAARIKYLQAQLCNLPQGSLQNKTKLLP 419

  Fly   459 SIEEAWNLPISLEMNSRQ----------------------------------------------- 476
            ||||||:|||..|:.|||
Frog   420 SIEEAWSLPIPAELTSRQGAMNSAQQACKPHHQNAESVLGLSQTPISQQSLPLHMIPSSQVDELS 484

  Fly   477 ----------------------------------------------------------------- 476

Frog   485 SPAKRKRTSSPAKNTSDTWSSGHLASHTPGQQQVHSWCLPPHKVQQLEQLRANRNNLNPAQKAAL 549

  Fly   477 ----------QQTAQM----------------------LP------------------------R 485
                      ||..||                      ||                        |
Frog   550 EQLEAQFVLMQQQQQMRQTGLSQVRSTGIANGPTADSTLPTNSLTGQQHQVALTRMPNAAQPGIR 614

  Fly   486 QVTKQSPV-QGPPP----------------------------------PYPH------------- 502
            ......|| .||.|                                  |||.
Frog   615 PACPAQPVANGPFPVGQVSCSTTGPVGSADTMLIGNNHITGNGSNGNVPYPQRNALALPHNRTNL 679

  Fly   503 ---------SQLSQSPI-----------------------PSKRIKEDGTSQQ-----------E 524
                     :||:.|..                       ||:.::..||..|           .
Frog   680 TSSAEEPWKNQLTNSTQGLHKGQSSHLAGPNCERPPSSTGPSQHLQAAGTGIQNQVGHPTMPSNS 744

  Fly   525 VTQ--------NNSQTSA--QNLINISESLNQRNFNAMPESNKSSE-----------------QS 562
            |||        :::.||.  |.:|...||....| .::||:::.||                 |.
Frog   745 VTQGAALNHLSSHTATSGGQQGIILTKESKPSGN-GSVPETSRHSEGTPNSTAGVEGLPNHVHQV 808

  Fly   563 VLDTFDDISNDIYK-----QNESIKLERLSQDALSNNED-------------------------- 596
            ..||....|:...|     .:::.:|..|.....:||..
Frog   809 TADTVPSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNVHPAVHTKTENSVASSP 873

  Fly   597 -----------------------------SRHDFIGGDNADISTTFKIQMDSKQ--LMVAVKLLP 630
                                         |.||.:.|:..:.|     |..:|:  .:.:.||.|
Frog   874 SSAISTATPSPKSTEQTMTNSVVSLKSPLSGHDKVNGEQTEDS-----QSPTKKDHSLPSHKLSP 933

  Fly   631 IDEPPV------------------------HCTILQVNAPPPSPPDCPPQKLTRDQLLPPTPSVH 671
            ...|.:                        :.:||....|||.||..|...|..|:|.|||||::
Frog   934 QTIPSMSVSIYPSSVEVLKACRNLGRNGLSNSSILLDKCPPPRPPPPPYPPLPTDKLNPPTPSIY 998

  Fly   672 LENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPD 734
            ||||:.||.|.|.:||.  .:|:.|:|||||.|||||||||||||||||.:|.||||||:.|..|
Frog   999 LENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHIVEVRTQLLQPAD 1063

  Fly   735 ENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSKDS 799
            ||||.:..|::|.|.|.||||||||||||||:|||:||:     :|::|   .||....||| :|
Frog  1064 ENWDPTGTKKIWRCESSRSHTTIAKYAQYQAASFQESLR-----EENEK---KSQHKDHSDS-ES 1119

  Fly   800 VSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVIL 864
            .|:.|   ..::.|...|.::||||:|||||:|||.||.||.||||||||:||.|:||||||.||
Frog  1120 TSSDN---SGRRRKGPFKTIKFGTNIDLSDERKWKLQLHELTKLPAFARVVSAGNLLSHVGHTIL 1181

  Fly   865 GMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGS 929
            |||||||||||||||||||||||||||:||||||||||||.||:.||..:|:.||||||::|.||
Frog  1182 GMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPETYWSVMHDFCEKNNINFLLGS 1246

  Fly   930 WWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYE 994
            |||.|||||:.|:|||||||:||||||:|||.|||||:||||||||||||||||.||.||:||||
Frog  1247 WWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTAFQYKLAVERYE 1311

  Fly   995 WNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGR 1059
            |||:|..||||||||||||:|:||||||.||||:||.|||:|||:...::|.:.:.|:||.::||
Frog  1312 WNKLQCVKSIVPMVHLSWNMAKNIKVSDPKLFEMIKYCLLRTLKHCQALREVLNASGIEIVWHGR 1376

  Fly  1060 GKNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVY 1121
            .|:|.:|||..|||||||:||:.::   :|.:||||..|:.|..|:|:..|.||::::.||.::|
Frog  1377 TKDEPAHYCSNCEVEVFNLLFVTKESNSQKTYVVHCHDCSRKSCPNLENFVVLEQFKMEELMQIY 1441

  Fly  1122 DSFTL 1126
            |.|||
Frog  1442 DLFTL 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	18/33 (55%)
		TPR_11	156..216	CDD:290150	31/59 (53%)
		TPR repeat	186..216	CDD:276809	15/29 (52%)
		TPR repeat	228..255	CDD:276809	14/26 (54%)
		TPR_11	264..337	CDD:290150	42/72 (58%)
		TPR repeat	265..300	CDD:276809	17/34 (50%)
		TPR repeat	307..334	CDD:276809	17/26 (65%)
		TPR_11	339..402	CDD:290150	49/62 (79%)
		TPR repeat	339..369	CDD:276809	27/29 (93%)
		TPR_1	340..373	CDD:278916	30/32 (94%)
		TPR repeat	374..402	CDD:276809	18/27 (67%)
		JmjC	870..978	CDD:202224	87/107 (81%)
kdm6a	XP_012811996.1	TPR	37..317	CDD:223533	134/332 (40%)
		TPR repeat	95..123	CDD:276809	17/81 (21%)
		TPR repeat	131..161	CDD:276809	16/29 (55%)
		TPR repeat	166..196	CDD:276809	15/29 (52%)
		TPR repeat	207..235	CDD:276809	14/27 (52%)
		TPR repeat	245..280	CDD:276809	17/34 (50%)
		PilF	<271..>403	CDD:225605	86/150 (57%)
		TPR repeat	287..314	CDD:276809	17/26 (65%)
		TPR repeat	319..349	CDD:276809	27/29 (93%)
		TPR repeat	354..380	CDD:276809	16/25 (64%)
		Glutenin_hmw	<477..>775	CDD:367362	32/297 (11%)
		SOG2	<727..>908	CDD:371045	29/181 (16%)
		JmjC	1153..1217	CDD:214721	56/63 (89%)
		JmjC	1187..1295	CDD:334913	87/107 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	498	1.000	Domainoid score	I354
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7586
Inparanoid	1	1.050	1044	1.000	Inparanoid score	I264
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm49532
Panther	1	1.100	-	-	LDO	PTHR14017
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R281
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190