DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4957 and TACO1

DIOPT Version :9

Sequence 1:	NP_609366.2	Gene:	CG4957 / 34374	FlyBaseID:	FBgn0032205	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_057444.2	Gene:	TACO1 / 51204	HGNCID:	24316	Length:	297	Species:	Homo sapiens

Alignment Length:	262	Identity:	72/262 - (27%)
Similarity:	120/262 - (45%)	Gaps:	41/262 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AGHSKWANIKHTKALKDGARAALFAKISRQIRMAIQEGNSADPAINSLLRTEIERALKQNMPSGT 66
            |||:||:.::|.|..||..|:.:|:|:...||:|::|| ..:|..||.|...:|....::||..|
Human    58 AGHNKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEG-GPNPEHNSNLANILEVCRSKHMPKST 121

  Fly    67 IQNTLNKFKASKVQLKKYRLDIKYKRNVYLICIFYTDNFSG---------------VKMDATPMI 116
            |:..| |.:.||              :.||:   |.....|               .:.|...::
Human   122 IETAL-KMEKSK--------------DTYLL---YEGRGPGGSSLLIEALSNSSHKCQADIRHIL 168

  Fly   117 KKAGGEFMDVGS--LFEDFGLIETRYDTAKLQNESSLEDKATNDAIELGAEEI-EVVDNVDGSV- 177
            .|.|| .|.||:  .|:..|:|....:..: :...:|| :|...|||.|||:: |..|..:.:|
Human   169 NKNGG-VMAVGARHSFDKKGVIVVEVEDRE-KKAVNLE-RALEMAIEAGAEDVKETEDEEERNVF 230

  Fly   178 NFLCSPVVLTSLSRNLEKAGYTVENSEHIFSPMNVVQLSPEEQKTYDVFVEKLRNLPGLEDIYDN 242
            .|:|....|..:.:.|:..|....:....|.|.:.|||:..:.:.....::.|.|...:..:|||
Human   231 KFICDASSLHQVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALSNHEDVIHVYDN 295

  Fly   243 VE 244
            :|
Human   296 IE 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4957	NP_609366.2	Transcrip_reg	6..243	CDD:279972	67/255 (26%)
TACO1	NP_057444.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..45
TACO1	NP_057444.2	Transcrip_reg	61..296	CDD:307710	67/256 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160033
Domainoid	1	1.000	71	1.000	Domainoid score	I9517
eggNOG	1	0.900	-	-		E1_COG0217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H39079
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5244
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62540
OrthoDB	1	1.010	-	-		D1199273at2759
OrthoFinder	1	1.000	-	-		FOG0002606
OrthoInspector	1	1.000	-	-		oto91620
orthoMCL	1	0.900	-	-		OOG6_101960
Panther	1	1.100	-	-	LDO	PTHR12532
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1857
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800