DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4953 and TRAPPC13

DIOPT Version :9

Sequence 1:	NP_609365.3	Gene:	CG4953 / 34373	FlyBaseID:	FBgn0032204	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001087224.1	Gene:	TRAPPC13 / 80006	HGNCID:	25828	Length:	418	Species:	Homo sapiens

Alignment Length:	417	Identity:	192/417 - (46%)
Similarity:	257/417 - (61%)	Gaps:	17/417 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEMVEP-DAHLVALKVMRLMRPTLVGLGPVVTCEPTDLV-QRFSSSQESDGMSGACAETLAAGQV 63
            ||:..| ..||:|||||||.:|||....| ||||..||. ..|:.....|..:...||.|..|::
Human     1 MEVNPPKQEHLLALKVMRLTKPTLFTNIP-VTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEM 64

  Fly    64 LLLPQSFGSIYLGETFASYICVHNTTPNPVECVTVKADLQSNTSRINLSMHENAKSPVVLPPGGT 128
            |.|||:||:|:|||||:|||.|||.:...|:.:.||||||:::.|:|||....|.:.  |.|...
Human    65 LTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAE--LKPDCC 127

  Fly   129 IDDVIRYEVKEIGTHILVCEVNYSTPAGYAQSLRKFFKFQVLKPLDVKTKFYNAE------IDEI 187
            |||||.:||||||||||||.|:|:|.||.....||||||||||||||||||||||      .||:
Human   128 IDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEV 192

  Fly   188 YLEAQIQNVTTSPFCLEKVELDGSEDYSVTPLNTLPN-GE--SVFTVKHMLQPNNSCQFLYCIKP 249
            :|||||||:||||..:|||.|:.|..|:||.||::.. ||  |.|..:..|||.::.|:|||:||
Human   193 FLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKP 257

  Fly   250 KGDIAKNVDTLRQFNNVGKLDIVWRSNLGEKGRLQTSQLQRLPFECKTLRLEVLDAKNTIKIGTI 314
            |.:.|:....::....:|||||||::||||:||||||||||:......:||.:....:|:.:...
Human   258 KNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEP 322

  Fly   315 FTFNCRVTN-TSEHPMKLNVRLAAKFSPDSQYTGCADFMLNLLQSGESAEFPLSVCPSKLGLVKI 378
            |...|::|| :||..|.|.:.:....|  ..:.|.:...|..|....|....|::..|..||..|
Human   323 FHITCKITNCSSERTMDLVLEMCNTNS--IHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSI 385

  Fly   379 TPLVLTNTLQNEQFTIENVVDVFVVNS 405
            :.|.||:|.....:..:::..|.||:|
Human   386 SGLRLTDTFLKRTYEYDDIAQVCVVSS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4953	NP_609365.3	DUF974	64..289	CDD:283752	132/233 (57%)
TRAPPC13	NP_001087224.1	DUF974	65..298	CDD:368770	133/234 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155662
Domainoid	1	1.000	249	1.000	Domainoid score	I2139
eggNOG	1	0.900	-	-		E1_KOG2625
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11792
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2591
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55751
OrthoDB	1	1.010	-	-		D1608721at2759
OrthoFinder	1	1.000	-	-		FOG0006259
OrthoInspector	1	1.000	-	-		oto88880
orthoMCL	1	0.900	-	-		OOG6_103469
Panther	1	1.100	-	-	LDO	PTHR13134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2871
SonicParanoid	1	1.000	-	-		X4540
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800