DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4953 and trappc13

DIOPT Version :9

Sequence 1:	NP_609365.3	Gene:	CG4953 / 34373	FlyBaseID:	FBgn0032204	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_012817757.1	Gene:	trappc13 / 549181	XenbaseID:	XB-GENE-5802753	Length:	418	Species:	Xenopus tropicalis

Alignment Length:	419	Identity:	193/419 - (46%)
Similarity:	264/419 - (63%)	Gaps:	21/419 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEMVEP-DAHLVALKVMRLMRPTLVGLGPVVTCEPTDLV-QRFSSSQESDGMSGACAETLAAGQV 63
            |::.:| ..||:|||||||.:|||....| ||||..||. ..||:..:.|..:...||||..|::
Frog     1 MDVNQPKQEHLLALKVMRLTKPTLFTNIP-VTCEERDLPGDLFSTLMKDDPSTVKGAETLMLGEM 64

  Fly    64 LLLPQSFGSIYLGETFASYICVHNTTPNPVECVTVKADLQSNTSRINLSMHENAKSPVV--LPPG 126
            |.|||:||:|:|||||:|||.|||.:...|:.:.||||||:::.|:|||    |.:.||  |.|.
Frog    65 LTLPQNFGNIFLGETFSSYISVHNDSNQVVKDIQVKADLQTSSQRLNLS----ASTAVVSELKPD 125

  Fly   127 GTIDDVIRYEVKEIGTHILVCEVNYSTPAGYAQSLRKFFKFQVLKPLDVKTKFYNAE------ID 185
            ..|||||.:||||||||||||.|:|:|..|.....||||||||||||||||||||||      .|
Frog   126 SCIDDVIHHEVKEIGTHILVCAVSYTTQTGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTD 190

  Fly   186 EIYLEAQIQNVTTSPFCLEKVELDGSEDYSVTPLNT-LPNGE--SVFTVKHMLQPNNSCQFLYCI 247
            |::|||||||:||||..:|||.|:.|..|:|:.||| :.||:  |.|..|..|||.::.|:|||:
Frog   191 EVFLEAQIQNITTSPMFMEKVSLEPSIMYNVSELNTVITNGDGCSTFGTKTYLQPLDTRQYLYCL 255

  Fly   248 KPKGDIAKNVDTLRQFNNVGKLDIVWRSNLGEKGRLQTSQLQRLPFECKTLRLEVLDAKNTIKIG 312
            |||.:.|:....::....:|||||||::||||:||||||||||:......:||.:....:|:::.
Frog   256 KPKPEFAEKAGVIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSIETIPDTVRLE 320

  Fly   313 TIFTFNCRVTN-TSEHPMKLNVRLAAKFSPDSQYTGCADFMLNLLQSGESAEFPLSVCPSKLGLV 376
            ..|...|::|| :||..|.|.:.:..  :....:.|.:...|..|....|....|::..|..||.
Frog   321 EPFDITCKITNCSSERTMDLVLEMCN--TNAIHWCGVSGRQLGKLHPSSSLHLTLALLSSVQGLQ 383

  Fly   377 KITPLVLTNTLQNEQFTIENVVDVFVVNS 405
            .::.|.||:|.....:..:::..|.||:|
Frog   384 SVSGLRLTDTFLKRTYEYDDIAQVCVVSS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4953	NP_609365.3	DUF974	64..289	CDD:283752	134/235 (57%)
trappc13	XP_012817757.1	DUF974	65..297	CDD:283752	134/235 (57%)
trappc13	XP_012817757.1	Transglut_C	308..>380	CDD:279295	16/73 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	258	1.000	Domainoid score	I1961
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11792
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2459
OMA	1	1.010	-	-		QHG55751
OrthoDB	1	1.010	-	-		D1608721at2759
OrthoFinder	1	1.000	-	-		FOG0006259
OrthoInspector	1	1.000	-	-		oto102749
Panther	1	1.100	-	-	LDO	PTHR13134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2871
SonicParanoid	1	1.000	-	-		X4540
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110