DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IFIT3 and Utx

DIOPT Version :9

Sequence 1:	NP_001026853.1	Gene:	IFIT3 / 3437	HGNCID:	5411	Length:	490	Species:	Homo sapiens
Sequence 2:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster

Alignment Length:	664	Identity:	115/664 - (17%)
Similarity:	211/664 - (31%)	Gaps:	246/664 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    25 FKEDSVSRDLEDRVCNQIEFLNTE-------FKATMYNLLAYI---------------------- 60
            |::|.:.|:|:.|....::..|::       .:.|:.||..||
  Fly     6 FEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQKFE 70

Human    61 ------KHLDG----NNEAALECLRQAEE---LIQQEHADQAEIRSLVT---------------- 96
                  :|::.    ||:......:.|:|   :|:::|.|:..:.:|..
  Fly    71 PSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALS 135

Human    97 -------------WGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFS----------NPYSIEYSEL 138
                         |.|:|::|         .|.|...|..|.|::          :|.....:|:
  Fly   136 AYQKYLRFRENNYWTNHAFIY---------GIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEV 191

Human   139 DCEEGWTQLKCG--------------------------------------RNERAKVCFEKALEE 165
            ....|.....||                                      :::.||..:|..|.|
  Fly   192 HLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNE 256

Human   166 KPNNPEFSSGLAIA---MYH----LDNHPEKQFST-DVLKQAIELSPDNQYVKVLLGLKLQKMNK 222
            |..:.|..:.:...   |||    |....|::.:. :.|:::||..|.:.....|||.....:||
  Fly   257 KNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINK 321

Human   223 EAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLE-------STPNNGYLYHQ 280
            ..:.......::|||....|...|....|:::.....|::.:...::       :..|.|.||..
  Fly   322 VHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYES 386

Human   281 IG------CCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFL 339
            .|      .||....:|:.....|       :|...:...|......|.|||      |....||
  Fly   387 CGQLRDAYACYLNATKQISFQKSS-------LIRKKQAIRMKKDTIGLSKGL------SQRITFL 438

Human   340 ETECYQTPFNKEVPDAEKQQSHQRYCNLQ---------KYNGKSEDTA----------------- 378
            |.:..|.|    :|....::  ::.|:::         :.|.:.:.||
  Fly   439 EGQLSQAP----LPSITSKR--RQLCSIEEAWNLPISLEMNSRQQQTAQMLPRQVTKQSPVQGPP 497

Human   379 --------VQHGLEGLSISKKSTDKEEIKDQPQ--------NVSENLLPQN-------------- 413
                    .|..:....|.:..|.::|:.....        |:||:|..:|
  Fly   498 PPYPHSQLSQSPIPSKRIKEDGTSQQEVTQNNSQTSAQNLINISESLNQRNFNAMPESNKSSEQS 562

Human   414 -APNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEM--GQGAV 475
             ...:..:...|:|||..:         :|.||.:||          .|..||...:.  |..|.
  Fly   563 VLDTFDDISNDIYKQNESI---------KLERLSQDA----------LSNNEDSRHDFIGGDNAD 608

Human   476 SSSPRELLSNSEQL 489
            .|:..::..:|:||
  Fly   609 ISTTFKIQMDSKQL 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IFIT3	NP_001026853.1	TPR_12	51..126	CDD:290160	22/138 (16%)
		TPR 1	51..84		11/67 (16%)
		TPR repeat	51..79	CDD:276809	9/59 (15%)
		TPR repeat	84..123	CDD:276809	10/67 (15%)
		TPR 2	94..127		9/61 (15%)
		TPR 3	136..169		10/70 (14%)
		TPR repeat	136..164	CDD:276809	7/65 (11%)
		TPR_19	150..213	CDD:291240	17/108 (16%)
		TPR 4	172..206		9/41 (22%)
		PRK02603	184..341	CDD:179448	35/170 (21%)
		TPR repeat	206..236	CDD:276809	5/29 (17%)
		TPR 5	207..240		8/32 (25%)
		TPR 6	241..274		4/39 (10%)
		TPR repeat	241..269	CDD:276809	4/27 (15%)
		TPR 7	415..448		7/32 (22%)
		TPR 8	450..481		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..490		6/25 (24%)
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	9/42 (21%)
		TPR_11	156..216	CDD:290150	11/68 (16%)
		TPR repeat	186..216	CDD:276809	4/29 (14%)
		TPR repeat	228..255	CDD:276809	3/26 (12%)
		TPR_11	264..337	CDD:290150	16/72 (22%)
		TPR repeat	265..300	CDD:276809	6/34 (18%)
		TPR repeat	307..334	CDD:276809	5/26 (19%)
		TPR_11	339..402	CDD:290150	11/62 (18%)
		TPR repeat	339..369	CDD:276809	4/29 (14%)
		TPR_1	340..373	CDD:278916	4/32 (13%)
		TPR repeat	374..402	CDD:276809	7/27 (26%)
		JmjC	870..978	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900