DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and CCR4

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_199596.1	Gene:	CCR4 / 834836	AraportID:	AT5G47850	Length:	751	Species:	Arabidopsis thaliana

Alignment Length:	589	Identity:	141/589 - (23%)
Similarity:	230/589 - (39%)	Gaps:	156/589 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 GMVGVEDCQKLP--QHKDCLSLG----ITIEVDKTENCYWEDGSTYRG--VANVSASGKPC-LRW 261
            ||:..|...|:|  .|...::.|    ..|.||....|:.:..|..|.  :|......:.| :||
plant   177 GMISCEGIAKVPSGDHYIAIAAGSRQACAITVDNDVECWGQTQSLPREKFLALAVGEDRGCGVRW 241

  Fly   262 S------WLMKEISDFPELI-----------GQNYC----RN----------------------- 282
            |      |........|:.:           |..:|    ||
plant   242 SNGTVVCWGNNNNFSLPQTLKDIHFTSIYAKGPMFCGVATRNYTLICWGNENFKSGVFTPFQGLI 306

  Fly   283 -----PGSVENS-PWCFVDSSRE---RIIELCDIPK------------CADKIW------IAIVG 320
                 ||..... |:..:..|:.   ..:.:||:.:            ..:|.|      ..:||
plant   307 SQVVMPGPCRRECPYRPLSGSQSLCGNELMICDLKRNDGEFPDTRAQNSKNKTWSRRNIAFLVVG 371

  Fly   321 TTAAIILIFIIIFAIILFKRRTIMHYGMR--NIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNL 383
            ......|:.:|.|.|.....|..:|...|  :...|:.|..:|.:...:.|.|.     |.|...
plant   372 CVGTFSLLLVISFLIFKSHCRCRVHDSGRLDDTRTIDIPKLEKRLCTLASLGNP-----GQLMEF 431

  Fly   384 S-DHVALNSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKG-------------QLLQPNK 434
            | |.:||.:           :.|:   |.|  .||.|:||.||:|             :|..|..
plant   432 SIDELALAT-----------DGFS---VRF--HLGIGSFGSVYQGVLSDGRHVAIKRAELTNPTL 480

  Fly   435 TTITVA-IKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHE 498
            :..|:. .:|.|::|       |..|:|.:|.|.|:|:|.:||...:.|...:::|||.||.|.:
plant   481 SGTTMRHRRADKDSA-------FVNELESMSRLNHKNLVRLLGFYEDTEERILVYEYMKNGSLAD 538

  Fly   499 FLISNSPTEGKSLSQLEFLQIALQISEGMQYLSAHHY-----VHRDLAARNCLVNEGLVVKISDF 558
            .|  ::| :...||....|.|||..:.|:|||  |.:     :|||:.:.|.|::.....|:|||
plant   539 HL--HNP-QFDPLSWQTRLMIALDAARGIQYL--HEFIVPPVIHRDIKSSNILLDATWTAKVSDF 598

  Fly   559 GLSR--DIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFS 621
            |||:  .....|...:...:...:.::..|...:.:.||:|||:||||||.|:.| |.:..:...
plant   599 GLSQMGPTEEDDVSHLSLHAAGTLGYIDPEYYKFQQLTTKSDVYSFGVVLLELLS-GHKAIHNNE 662

  Fly   622 NQEVINLI----------RSRQLLSAPENCPTA--------VYSLMIECWHEQSVKRPTFTDISN 668
            ::...||:          .:.::|......||.        |..|..||....|.|||:..::.:
plant   663 DENPRNLVEYVVPYILLDEAHRILDQRIPPPTPYEIEAVAHVGYLAAECLMPCSRKRPSMVEVVS 727

  Fly   669 RLKT 672
            :|::
plant   728 KLES 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	7/27 (26%)
		KR	235..312	CDD:214527	20/144 (14%)
		PTKc_Ror	404..673	CDD:270642	89/308 (29%)
		Pkinase_Tyr	410..670	CDD:285015	87/298 (29%)
CCR4	NP_199596.1	STKc_IRAK	449..730	CDD:270968	85/293 (29%)
CCR4	NP_199596.1	TyrKc	449..729	CDD:197581	85/292 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I2087
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050