DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and GSO2

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_199283.1	Gene:	GSO2 / 834499	AraportID:	AT5G44700	Length:	1252	Species:	Arabidopsis thaliana

Alignment Length:	575	Identity:	126/575 - (21%)
Similarity:	233/575 - (40%)	Gaps:	160/575 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DVFSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGMVGVEDCQKLPQHKD 221
            |:...:.:.:.|.|  ...|.::  |..:|..|:|..:         |.|.:|           |
plant   775 DLSYNNFTGRIPST--ISTLPKL--ESLDLSHNQLVGE---------VPGQIG-----------D 815

  Fly   222 CLSLG-ITIEVDKTENCYWEDGSTYRG---VANVSASGKPCLRWSWLMKEISDFPELIGQNYCRN 282
            ..||| :.:..:..|....:..|.::.   |.|....|.|.                   ::|..
plant   816 MKSLGYLNLSYNNLEGKLKKQFSRWQADAFVGNAGLCGSPL-------------------SHCNR 861

  Fly   283 PGSVENSPWCFVDSSRERIIELCDIPKCADKIWIAIVGTTAAIILIFIIIFAIILFKRRTIMHYG 347
            .|           |..:|.:.    ||..  :.|:.:.:.|||.|:.::|  |:.||:...:...
plant   862 AG-----------SKNQRSLS----PKTV--VIISAISSLAAIALMVLVI--ILFFKQNHDLFKK 907

  Fly   348 MRNIHNINTPSADKNIYGNSQLNNAQDAGR----GNLGNLSDHVALNSKLIERNTLLRINHFTLQ 408
            :|.              |||..::...:.:    .|.|..||        |:.:.::...|:.
plant   908 VRG--------------GNSAFSSNSSSSQAPLFSNGGAKSD--------IKWDDIMEATHYL-- 948

  Fly   409 DVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVC 473
            :.||:  :|.|..|||||.:|    |...|:|:|.:.....:.:.:.|.||::.:..::|:::|.
plant   949 NEEFM--IGSGGSGKVYKAEL----KNGETIAVKKILWKDDLMSNKSFNREVKTLGTIRHRHLVK 1007

  Fly   474 ILGVVLNKEPYC---------MLFEYMANGDLHEFLISNSPTEGKSLSQLEF-LQIALQISEGMQ 528
            ::|       ||         :::||||||.:.::|.:|..|:.|.:...|. |:|||.:::|::
plant  1008 LMG-------YCSSKADGLNLLIYEYMANGSVWDWLHANENTKKKEVLGWETRLKIALGLAQGVE 1065

  Fly   529 YLSAHHY------VHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLL--PVRWMPS 585
            ||   ||      ||||:.:.|.|::..:...:.||||::.:..:.....:|.::.  ...::..
plant  1066 YL---HYDCVPPIVHRDIKSSNVLLDSNIEAHLGDFGLAKILTGNYDTNTESNTMFAGSYGYIAP 1127

  Fly   586 ESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIR-------------------- 630
            |.....|.|.:|||:|.|:||.||.: |..|.....::|. :::|
plant  1128 EYAYSLKATEKSDVYSMGIVLMEIVT-GKMPTEAMFDEET-DMVRWVETVLDTPPGSEAREKLID 1190

  Fly   631 --SRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDIS--------NRLKTWHE 675
              .:.||...|.....|..:.::|......:||:....|        ||..::.|
plant  1191 SELKSLLPCEEEAAYQVLEIALQCTKSYPQERPSSRQASEYLLNVFNNRAASYRE 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	15/71 (21%)
		KR	235..312	CDD:214527	12/79 (15%)
		PTKc_Ror	404..673	CDD:270642	80/316 (25%)
		Pkinase_Tyr	410..670	CDD:285015	78/307 (25%)
GSO2	NP_199283.1	LRRNT_2	28..68	CDD:285463
		leucine-rich repeat	76..96	CDD:275380
		LRR_RI	135..406	CDD:238064
		LRR_8	145..204	CDD:290566
		leucine-rich repeat	146..169	CDD:275380
		leucine-rich repeat	170..193	CDD:275380
		leucine-rich repeat	194..241	CDD:275380
		LRR_8	240..300	CDD:290566
		leucine-rich repeat	242..265	CDD:275380
		leucine-rich repeat	266..289	CDD:275380
		PLN00113	285..1232	CDD:215061	123/560 (22%)
		leucine-rich repeat	290..313	CDD:275380
		leucine-rich repeat	314..338	CDD:275380
		leucine-rich repeat	339..362	CDD:275380
		leucine-rich repeat	363..386	CDD:275380
		leucine-rich repeat	387..410	CDD:275380
		leucine-rich repeat	411..434	CDD:275380
		leucine-rich repeat	435..458	CDD:275380
		leucine-rich repeat	459..482	CDD:275380
		leucine-rich repeat	483..506	CDD:275380
		leucine-rich repeat	507..528	CDD:275380
		leucine-rich repeat	531..554	CDD:275380
		leucine-rich repeat	555..571	CDD:275380
		LRR_RI	603..843	CDD:238064	17/91 (19%)
		leucine-rich repeat	604..625	CDD:275380
		leucine-rich repeat	626..649	CDD:275380
		leucine-rich repeat	650..673	CDD:275380
		leucine-rich repeat	674..697	CDD:275380
		leucine-rich repeat	698..721	CDD:275380
		leucine-rich repeat	722..745	CDD:275380
		leucine-rich repeat	746..769	CDD:275380
		leucine-rich repeat	770..794	CDD:275380	4/20 (20%)
		leucine-rich repeat	795..818	CDD:275380	8/44 (18%)
		leucine-rich repeat	819..839	CDD:275380	3/19 (16%)
		STKc_IRAK	954..1232	CDD:270968	75/293 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000