DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and Musk

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_112323.2	Gene:	Musk / 81725	RGDID:	3211	Length:	868	Species:	Rattus norvegicus

Alignment Length:	684	Identity:	205/684 - (29%)
Similarity:	306/684 - (44%)	Gaps:	185/684 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QQSSGICHIYNGTICRDVL-SNAHVFVSPNLTMNDLEER----LKAAYGVIKESKDMNANCRMYA 94
            ::|.|.|..|.|.:|..|| .::.||.  |.:..|.||.    :..|:   .|.|.::..||..|
  Rat   311 KESKGYCAQYRGEVCDAVLVKDSLVFF--NTSYPDPEEAQELLIHTAW---NELKAVSPLCRPAA 370

  Fly    95 LPSLCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVF 159
            ...||                                                    :.::::..
  Rat   371 EALLC----------------------------------------------------NHLFQECS 383

  Fly   160 STDISSKYPPTRESENLKRICREECELLENELCQKEYAI--AKRHPVI---GM--VGVEDCQKLP 217
            |..:.:..|          ||||.|..::...|.||:..  .|.|..:   ||  :.|.:|.|||
  Rat   384 SGVLPTPMP----------ICREYCLAVKELFCAKEWLAMEGKTHRGLYRSGMHFLPVPECSKLP 438

  Fly   218 -QHKDCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWL---MKEISDFPELIGQN 278
             .|:|..:                                 |.|..:|   .:.|:.||.:
  Rat   439 SMHQDPTA---------------------------------CTRLPYLDYKKENITTFPSI---- 466

  Fly   279 YCRNPGSVENSPWCFVDSSRERIIELCDIPKCADKIWIAIVGTTAAIILIFIIIFAIILFKRRTI 343
                             :|.:..:::.::|.......::...:...||.| :..||:......|.
  Rat   467 -----------------TSSKPSVDIPNLPASTSSFAVSPAYSMTVIISI-MSCFAVFALLTITT 513

  Fly   344 MHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALN----SKLIERNTLLRIN- 403
            ::...|.               ....|..:::....|..|...:.|:    :.:.:|..|| :|
  Rat   514 LYCCRRR---------------REWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLL-LNP 562

  Fly   404 -----HFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKENASVKTQQDFKREIE 461
                 .:...::|::.::||||||:|::.:.  |.|.:....||:|.|||.||...|.||:||..
  Rat   563 KLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 627

  Fly   462 LISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQ------------- 513
            |:::..:.|||.:|||....:|.|:||||||.|||:|||.|.||....|||.
  Rat   628 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPG 692

  Fly   514 ------LEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRV 572
                  .|.|.||.|::.||.|||...:||||||.|||||.|.:||||:||||||:|||:|||:.
  Rat   693 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKA 757

  Fly   573 QSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSA 637
            .....:|:||||.|||.|.::|||||||::|||||||:|||:|||||.:::|||..:|...:|:.
  Rat   758 DGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILAC 822

  Fly   638 PENCPTAVYSLMIECWHEQSVKRPTFTDISNRLK 671
            |||||..:|:||..||.:....||:|..|...|:
  Rat   823 PENCPLELYNLMRLCWSKLPADRPSFCSIHRILQ 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	42/201 (21%)
		KR	235..312	CDD:214527	8/79 (10%)
		PTKc_Ror	404..673	CDD:270642	139/289 (48%)
		Pkinase_Tyr	410..670	CDD:285015	138/280 (49%)
Musk	NP_112323.2	IgI_1_MuSK	28..117	CDD:409562
		Ig strand B	45..49	CDD:409562
		Ig strand C	58..62	CDD:409562
		Ig strand E	82..86	CDD:409562
		Ig strand F	96..101	CDD:409562
		Ig strand G	110..113	CDD:409562
		IgI_2_MuSK	122..209	CDD:409560
		Ig strand B	138..142	CDD:409560
		Ig strand C	151..155	CDD:409560
		Ig strand E	173..177	CDD:409560
		Ig strand F	187..192	CDD:409560
		Ig strand G	201..204	CDD:409560
		Ig_3	218..286	CDD:404760
		Ig strand A'	222..225	CDD:409353
		Ig strand B	229..236	CDD:409353
		Ig strand C	242..247	CDD:409353
		Ig strand C'	250..252	CDD:409353
		Ig strand D	258..262	CDD:409353
		Ig strand E	268..272	CDD:409353
		Ig strand F	278..286	CDD:409353
		CRD_TK_ROR_related	313..457	CDD:143578	46/243 (19%)
		PTKc_Musk	568..857	CDD:133181	139/289 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820