DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ror and Ptk7

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	XP_006524986.1	Gene:	Ptk7 / 71461	MGIID:	1918711	Length:	1088	Species:	Mus musculus

Alignment Length:	735	Identity:	182/735 - (24%)
Similarity:	320/735 - (43%)	Gaps:	155/735 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QQSSGI--CHIYN--GTICRDVLSNAHVFVSPNLTMNDLEERL-KAAYGVIKESKDMNANCRMYA 94
            :..:|:  ||..|  |...:||          |:|:..:...| |.....::|.|....:|...|
Mouse   401 ESDTGVYTCHASNLAGQRRQDV----------NITVATVPTWLRKPQDSQLEEGKPGYLHCLTQA 455

  Fly    95 LPSLCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVF 159
            .|              :..::::.|     :.|.:...|.:.:|:..::..|:.....|:|..|.
Mouse   456 TP--------------KPTVIWYRN-----QMLISEDSRFEVSKNGTLRINSVEVYDGTLYRCVS 501

  Fly   160 STDISS-------------KYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGMVGVE 211
            ||...|             |:.|..:.        ::|...:.|......|..:..|.:..|..
Mouse   502 STPAGSIEAQARVQVLEKLKFTPPPQP--------QQCMEFDKEATVPCSATGREKPTVKWVRA- 557

  Fly   212 DCQKLPQ--------------------HKDCLS-----------LGITIEVDKTENCYWEDGSTY 245
            |...||:                    :..|::           :.:|:.|..|.....|..:.|
Mouse   558 DGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTTVY 622

  Fly   246 RG---VANVSASG--KPCLRW----------------------SWLMKEISDFPELIGQNYCRNP 283
            :|   :....|.|  ||.::|                      |.::.:::  ||..|...|...
Mouse   623 QGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVA--PEDSGSYTCIAG 685

  Fly   284 GSVE----NSPWCFVDSSRERIIELCDIP------KCADKIWIAIVGTTAAIILIFIIIFAIILF 338
            .|..    .:|...||   :.::|..:.|      |....|.:::....|.||.:..::|   ..
Mouse   686 NSCNIRHTEAPLLVVD---KPVMEDSEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMF---YC 744

  Fly   339 KRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNS------KLIERN 397
            |:|.   ...|..........:........|.|.|.:     ..:.:.|||.|      ...:|:
Mouse   745 KKRC---KAKRLQKQPEGEEPEMECLNGGPLQNGQPS-----AEIQEEVALTSLGSGPPATNKRH 801

  Fly   398 TLLRINHFTLQDVEFLEELGEGAFGKVY--KGQLLQPNKTTITVAIKALKENASVKTQQDFKREI 460
            :.....||....::.:..||:..||:|:  |.|.::...|...|.:|:| ::...:.|.||:||:
Mouse   802 SAGDRMHFPRASLQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSL-QSRDEQQQLDFRREV 865

  Fly   461 ELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFL-ISNSPTE---GKSLSQLEFLQIAL 521
            |:...|.|.|:|.:||:....||:.|:.||:..|||.:|| ||.:..|   .:.||..:.:.:..
Mouse   866 EMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKDEKLKSQPLSTKQKVALCS 930

  Fly   522 QISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSE 586
            |::.||::||.:.:||:||||||||::....||:|..|||:|:|:|:||..: ::.:|:|||..|
Mouse   931 QVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPE 994

  Fly   587 SILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVI-NLIRSRQLLSAPENCPTAVYSLMI 650
            ::|.|.|:|:||||:|||::||::::|..|:.|.::.||: :|...:..|..||.||:.:|.||.
Mouse   995 AVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQ 1059

  Fly   651 ECWHEQSVKRPTFTDISNRL 670
            .||......||:|::|::.|
Mouse  1060 RCWAPNPKDRPSFSEIASTL 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	38/237 (16%)
		KR	235..312	CDD:214527	20/113 (18%)
		PTKc_Ror	404..673	CDD:270642	105/274 (38%)
		Pkinase_Tyr	410..670	CDD:285015	102/266 (38%)
Ptk7	XP_006524986.1	IGc2	63..125	CDD:197706
		Ig2_PTK7	164..240	CDD:143237
		Ig_3	245..320	CDD:372822
		IGc2	354..416	CDD:197706	4/14 (29%)
		Ig	430..516	CDD:386229	18/104 (17%)
		Ig	521..606	CDD:386229	11/93 (12%)
		Ig	627..687	CDD:319273	10/61 (16%)
		PTK_CCK4	808..1081	CDD:133178	105/274 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810