DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ror and ntrk2b

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_001184090.2	Gene:	ntrk2b / 570240	ZFINID:	ZDB-GENE-010126-2	Length:	799	Species:	Danio rerio

Alignment Length:	625	Identity:	196/625 - (31%)
Similarity:	295/625 - (47%)	Gaps:	138/625 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DVFSTDI---------------------------SSKYPPTRESENLKRICREECELLE----NE 190
            :||.||:                           ||::||...|..:.::..:....|.    |:
Zfish   191 EVFPTDVSQMAGSDATVICNASGSPTPELTWTLNSSEHPPLSTSHEISKMDLQSVLTLNGLSPND 255

  Fly   191 -----LCQKEYAIAKRHPVIGMVGVEDCQK-----LPQHKDCLSLGITIEVDKTENCYWEDGSTY 245
                 :|..|..:.:....: |:.:.....     ||:......:...:..:...:.:|     |
Zfish   256 NGRKLICSAENIVGQIEATV-MLNISFPPTVLELYLPERSQDWCIPFVVTGNPRPDLHW-----Y 314

  Fly   246 RGVANVSASGKPCLRWSWLMKEISDF--PELIGQNYCRNPGSVENSPWCFVDSSR---------- 298
            .       .|||.....::..||.|.  .|..|......|..:.|..:..|.|:.
Zfish   315 H-------EGKPLEEQEYIRTEIHDITNTEYHGCLKLDTPTHIHNGIYTLVASNEFGEDRGNVTA 372

  Fly   299 --ERIIEL----------------CDIPKCADKIWIAIVGTTAAIILIFIIIFAIILFKRRTIMH 345
              .||.::                .|||...|::.:.||...|.:.|...|:..:.|...|: ..
Zfish   373 HFMRIPDVDHSGIEGVFYYDTTVSPDIPPLEDRVAVYIVVGIAGVALTGCILMLVFLKYGRS-SK 436

  Fly   346 YGMRN--------------IHNI----NTPSA-----DKNIYGNSQ---LNNAQDAGRGNLGNLS 384
            :||:.              :|::    ||||:     |..|.|.::   :.|.|
Zfish   437 FGMKGSSSVISNDDDSASPLHHVSNGNNTPSSSEMGPDAVIIGMTKIPVIENPQ----------- 490

  Fly   385 DHVALNSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKEN 447
             :......:::.:||  :.|....::....||||||||||:..:.  |.|::..|.||:|.|||
Zfish   491 -YFRNPGSMLKSDTL--VQHIKRHNILLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLKE- 551

  Fly   448 ASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSP-----TE 507
            ||...:.||.||.||:::|:|::||...||.:..:|..|:||||.:|||::||.::.|     .:
Zfish   552 ASESGRADFHREAELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAD 616

  Fly   508 GK-----SLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSS 567
            |:     .|:|.:.|.||.||:.||.||::.|:||||||.|||||.|.|:|||.|||:|||:||:
Zfish   617 GQQSLLVELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 681

  Fly   568 DYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSR 632
            |||||...::||:||||.|||:|.:|||||||||.|||||||::||.||:|..||.|||..|...
Zfish   682 DYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQG 746

  Fly   633 QLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRLKT 672
            ::|..|..||..||.||:.||..:...|....:|.|.|::
Zfish   747 RVLQRPRTCPKEVYDLMLGCWQREPYMRLNIKEIHNLLQS 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	16/111 (14%)
		KR	235..312	CDD:214527	19/106 (18%)
		PTKc_Ror	404..673	CDD:270642	139/281 (49%)
		Pkinase_Tyr	410..670	CDD:285015	137/271 (51%)
ntrk2b	NP_001184090.2	leucine-rich repeat	62..86	CDD:275378
		LRR_8	85..144	CDD:290566
		leucine-rich repeat	87..110	CDD:275378
		leucine-rich repeat	111..133	CDD:275378
		IG_like	194..279	CDD:214653	12/85 (14%)
		Ig	205..275	CDD:143165	9/69 (13%)
		Ig_TrkB_d5	297..375	CDD:143263	14/89 (16%)
		PTKc_TrkB	507..796	CDD:270675	139/281 (49%)
		Pkinase_Tyr	513..784	CDD:285015	137/271 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910