DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and Alk

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	150/472 - (31%)
Similarity:	245/472 - (51%)	Gaps:	71/472 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 EDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENSP---WCFVD------ 295
            |.||:|     :|.|..        ::|||:    |.......||::...|   .|..|
  Fly  1019 EGGSSY-----ISPSRS--------LREISE----IHAGASSGPGAIIIIPAIEGCGCDYRCVAL 1066

  Fly   296 ---SSRERII------------ELCDIPKCADK----IWIAIVGTTAAIILIFIIIFAIILF--- 338
               .|:.|.|            ..|:|.:.|.|    ..::|:..:.|::.|.|.....:|:
  Fly  1067 DEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRY 1131

  Fly   339 --KRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNS-KLIERNTLL 400
              |:::...:.|....::.......|| .:|.|||. :...|..|.|:.|:.:|| ..:.|::|.
  Fly  1132 QRKKQSKKRHKMLVEQDLQLTRLRNNI-DDSNLNNF-NPNYGCDGILNGHIDVNSLPQVARDSLQ 1194

  Fly   401 RINHFTLQDVEFLEELGEGAFGKVYKGQLLQPNKTTIT--VAIKALKENASVKTQQDFKREIELI 463
            .:|           .||:||||:||.......:...:.  ||:|.|:|:...:.::||.:|..::
  Fly  1195 LVN-----------ALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIM 1248

  Fly   464 SDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLIS--NSPTEGKSLSQLEFLQIALQISEG 526
            :...|.|:|.::||..:::||.::.|.:|.|||.:||..  |:|.....|:..:.|..||.:::|
  Fly  1249 AKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKG 1313

  Fly   527 MQYLSAHHYVHRDLAARNCLVNE---GLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESI 588
            .:|:.:..::|||:||||||::.   |.||||:|||:|||||.|||||...|::||::|||.|:.
  Fly  1314 CRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAF 1378

  Fly   589 LYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECW 653
            |.|.||:::||||||::|||::|.|..||.|..|.:|:.|:.....|.:|..||.::|.:|.:||
  Fly  1379 LDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCW 1443

  Fly   654 HEQSVKRPTFTDISNRL 670
            :.....||||..:...|
  Fly  1444 NPTPEDRPTFITLLEHL 1460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568
		KR	235..312	CDD:214527	20/95 (21%)
		PTKc_Ror	404..673	CDD:270642	106/274 (39%)
		Pkinase_Tyr	410..670	CDD:285015	105/266 (39%)
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	109/286 (38%)
		TyrKc	1193..1460	CDD:197581	107/277 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455366
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940