DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ror and ROR2

DIOPT Version :9

Sequence 1:NP_476962.1 Gene:Ror / 34367 FlyBaseID:FBgn0010407 Length:685 Species:Drosophila melanogaster
Sequence 2:NP_004551.2 Gene:ROR2 / 4920 HGNCID:10257 Length:943 Species:Homo sapiens


Alignment Length:682 Identity:244/682 - (35%)
Similarity:356/682 - (52%) Gaps:121/682 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 SHNVDSRIYGFQQSSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEERLKAAYGVIKESKDMNA 88
            :|:.:..........|.|..|.|..|...:.|..::|.......::|.|:.||:.:|..|..::.
Human   157 THSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSD 221

  Fly    89 NCRMYALPSLCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKST 153
            .|..:|:||.|....|:|                                               
Human   222 QCSQFAIPSFCHFVFPLC----------------------------------------------- 239

  Fly   154 IYEDVFSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGM-VGVEDCQKLP 217
                    |..|:.|..||      :||:|||:||::||::||.||:.:|:|.| :.:..|:.||
Human   240 --------DARSRTPKPRE------LCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP 290

  Fly   218 QHK-----DCLSLGITIE-VDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEIS------D 270
            ..:     :|:.:||..| :.:...||...|..|||.|:.:.||..|..|: |....|      |
Human   291 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWA-LQHPHSHHLSSTD 354

  Fly   271 FPELIGQN-YCRNPGSVENSPWCFVDSSRERIIELCDIPKC----ADKIWIA-IVGTTAAIILIF 329
            ||||.|.: ||||||.....||||..:...| :||||:|.|    :.|:.|. |:..:.||.|:.
Human   355 FPELGGGHAYCRNPGGQMEGPWCFTQNKNVR-MELCDVPSCSPRDSSKMGILYILVPSIAIPLVI 418

  Fly   330 IIIFAIILFKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKLI 394
            ..:|.::...|                         |.|..:|....|..| ..|....:...||
Human   419 ACLFFLVCMCR-------------------------NKQKASASTPQRRQL-MASPSQDMEMPLI 457

  Fly   395 ERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQLL--QPNKTTITVAIKALKENASVKTQQDFK 457
            .::...::...:|..|.|:|||||..|||||||.|.  .|.:.|..||||.||:.|....:::|:
Human   458 NQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFR 522

  Fly   458 REIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSP-----------TEGKSL 511
            .|..|.:.|:|.|:||:||||...:|..|:|.|.::|||||||:..||           |...:|
Human   523 HEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSAL 587

  Fly   512 SQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKS 576
            ...:|:.:..||:.||:|||:||.||:|||.||.||.:.|.|||||.||.|::|::|||::...|
Human   588 EPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNS 652

  Fly   577 LLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENC 641
            |||:|||..|:|:||||:.:||:||:||||||::|||:|||.|:|||:|:.:||:||:|..|::|
Human   653 LLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717

  Fly   642 PTAVYSLMIECWHEQSVKRPTFTDISNRLKTW 673
            |..||:||||||:|...:||.|.||.:||:.|
Human   718 PAWVYALMIECWNEFPSRRPRFKDIHSRLRAW 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RorNP_476962.1 CRD_TK_ROR_like 39..228 CDD:143568 46/194 (24%)
KR 235..312 CDD:214527 36/87 (41%)
PTKc_Ror 404..673 CDD:270642 142/281 (51%)
Pkinase_Tyr 410..670 CDD:285015 139/272 (51%)
ROR2NP_004551.2 I-set 64..152 CDD:254352
IGc2 75..141 CDD:197706
CRD_TK_ROR2 170..309 CDD:143577 47/199 (24%)
KR 314..395 CDD:214527 35/82 (43%)
PTKc_Ror2 466..749 CDD:270673 142/282 (50%)
Pkinase_Tyr 473..746 CDD:285015 139/272 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..931
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 323 1.000 Domainoid score I1214
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 416 1.000 Inparanoid score I1827
Isobase 1 0.950 - 0 Normalized mean entropy S2196
OMA 1 1.010 - - QHG48666
OrthoDB 1 1.010 - - D222671at33208
OrthoFinder 1 1.000 - - FOG0003730
OrthoInspector 1 1.000 - - otm41423
orthoMCL 1 0.900 - - OOG6_105406
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3136
SonicParanoid 1 1.000 - - X2586
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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