DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ror and ROR1

DIOPT Version :9

Sequence 1:NP_476962.1 Gene:Ror / 34367 FlyBaseID:FBgn0010407 Length:685 Species:Drosophila melanogaster
Sequence 2:NP_005003.2 Gene:ROR1 / 4919 HGNCID:10256 Length:937 Species:Homo sapiens


Alignment Length:700 Identity:266/700 - (38%)
Similarity:364/700 - (52%) Gaps:155/700 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 QSSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSLCF 100
            :..|.|..|.|..|...:.|..|::.......::|.::.||:.:|..|..::..|..:|:||||.
Human   165 EEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCH 229

  Fly   101 SSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISS 165
            .:.|.|                                                       |.:|
Human   230 YAFPYC-------------------------------------------------------DETS 239

  Fly   166 KYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGM-VGVEDCQKLPQHK-----DCLS 224
            ..|..|:      :||:|||:|||.|||.||..|:.:|:|.| :.:.:|:.|||.:     :|:.
Human   240 SVPKPRD------LCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIR 298

  Fly   225 LGITI--EVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISD-----FPELI-GQNYCR 281
            :||.:  .::|...||...|..|||..:|:.||:.|..|:........     ||||. |.:|||
Human   299 IGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCR 363

  Fly   282 NPGSVENSPWCF-VDSSRERIIELCDIPKCADK------------IWIAIVGTTAAIILIFIIIF 333
            |||:.:.:|||| :|.:.:.  :|||||.|..|            |.:..|....||.|:|..|.
Human   364 NPGNQKEAPWCFTLDENFKS--DLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFFFIC 426

  Fly   334 AIILFKRRTIMHYGMRNIHNINTPSA-----DKNIYGN----SQLNNAQDAGRGNLGNLSDHVAL 389
            .             .||  |..:.||     .|::.|.    |.||..:...:.           
Human   427 V-------------CRN--NQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKA----------- 465

  Fly   390 NSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQLLQPNKT-TITVAIKALKENASVKTQ 453
                         ....|..|.|:|||||.||||:|||.|..|... ...||||.||:..:.:..
Human   466 -------------KELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQW 517

  Fly   454 QDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSP------------T 506
            .:|::|..|:::|.|.||||:||.|..::|.||||||:..||||||||..||            |
Human   518 TEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGT 582

  Fly   507 EGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYR 571
            ...||...:||.||:||:.||:|||:|.:||:||||||.|:.|.|.|||||.||||:|||:||||
Human   583 VKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYR 647

  Fly   572 VQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLS 636
            ||||||||:||||.|:|:||||:::||:||||||||||:|:|:||||||||||||.::|.||||.
Human   648 VQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLP 712

  Fly   637 APENCPTAVYSLMIECWHEQSVKRPTFTDISNRLKTWHEG---HFKASNP 683
            ..|:||..:||||.|||:|...:||.|.||..||::| ||   |..::.|
Human   713 CSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSW-EGLSSHTSSTTP 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RorNP_476962.1 CRD_TK_ROR_like 39..228 CDD:143568 47/194 (24%)
KR 235..312 CDD:214527 33/83 (40%)
PTKc_Ror 404..673 CDD:270642 161/281 (57%)
Pkinase_Tyr 410..670 CDD:285015 158/272 (58%)
ROR1NP_005003.2 IG_like 66..148 CDD:214653
CRD_TK_ROR1 166..307 CDD:143576 48/201 (24%)
KR 311..393 CDD:214527 33/83 (40%)
PTKc_Ror1 467..749 CDD:270672 161/281 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..779 1/8 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..890
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 323 1.000 Domainoid score I1214
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3675
Inparanoid 1 1.050 416 1.000 Inparanoid score I1827
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48666
OrthoDB 1 1.010 - - D222671at33208
OrthoFinder 1 1.000 - - FOG0003730
OrthoInspector 1 1.000 - - otm41423
orthoMCL 1 0.900 - - OOG6_105406
Panther 1 1.100 - - LDO PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3136
SonicParanoid 1 1.000 - - X2586
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.870

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