DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ror and NTRK2

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_006171.2	Gene:	NTRK2 / 4915	HGNCID:	8032	Length:	838	Species:	Homo sapiens

Alignment Length:	758	Identity:	220/758 - (29%)
Similarity:	345/758 - (45%)	Gaps:	176/758 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FIVCISLVLLFTKKDVGSHNVDSRIYGFQQSSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEE 71
            |.....::.:.|.::..|......:|...:||....:.|..|....|.:|:: .:||||
Human   150 FTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANL-AAPNLT------ 207

  Fly    72 RLKAAYGVIKESKDMNANCRMYA--LPSLCFS-----SMPICRTPERTNLLYFANVAT--NAKQL 127
                    ::|.|.:..:|.:..  :|::.:.     |..:..|......|...|:::  :.||:
Human   208 --------VEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQI 264

  Fly   128 KNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREECELLENELC 192
            ..|:                   ::.:.||..|.:::..:.||             ...||:...
Human   265 SCVA-------------------ENLVGEDQDSVNLTVHFAPT-------------ITFLESPTS 297

  Fly   193 QKEYAI---AKRHP-------VIGMVGVED---CQKL-----PQHKDCLSLGITIEVDK------ 233
            ...:.|   .|.:|       ..|.:..|.   |.|:     .::..||.|.....::.
Human   298 DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLI 362

  Fly   234 TENCYWED----GSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENSPWCFV 294
            .:|.|.:|    .:.:.|...:.....|            ::|::|.::|    |:..|......
Human   363 AKNEYGKDEKQISAHFMGWPGIDDGANP------------NYPDVIYEDY----GTAANDIGDTT 411

  Fly   295 DSSRERIIELCDIPKCADKIWIAIVGTTAAIILIFIIIFA--IILFKRRTIMH--YGMRN----- 350
            :.|.|  |...|:   .||.....:...|.:::..::.|.  ::||..:...|  :||::
Human   412 NRSNE--IPSTDV---TDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFG 471

  Fly   351 -------------------------IHNI----NTPSA-----DKNIYGNSQ---LNNAQDAGRG 378
                                     :|:|    ||||:     |..|.|.::   :.|.|..|
Human   472 FGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFG-- 534

  Fly   379 NLGNLSDHVALNSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAI 441
                     ..||:| :.:|.  :.|....::....||||||||||:..:.  |.|.:..|.||:
Human   535 ---------ITNSQL-KPDTF--VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAV 587

  Fly   442 KALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSP- 505
            |.||: ||...::||.||.||:::|:|::||...||.:..:|..|:||||.:|||::||.::.|
Human   588 KTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPD 651

  Fly   506 ----TEGK---SLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRD 563
                .||.   .|:|.:.|.||.||:.||.||::.|:||||||.|||||.|.|:|||.|||:|||
Human   652 AVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 716

  Fly   564 IYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINL 628
            :||:|||||...::||:||||.|||:|.||||||||||.|||||||::||.||:|..||.|||..
Human   717 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781

  Fly   629 IRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRLK 671
            |...::|..|..||..||.||:.||..:...|.....|...|:
Human   782 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	36/215 (17%)
		KR	235..312	CDD:214527	14/80 (18%)
		PTKc_Ror	404..673	CDD:270642	139/278 (50%)
		Pkinase_Tyr	410..670	CDD:285015	137/269 (51%)
NTRK2	NP_006171.2	LRR_8	92..150	CDD:404697	220/758 (29%)
		LRR 1	92..113
		LRR 2	116..137
		TPKR_C2	152..195	CDD:407151	7/42 (17%)
		Ig	205..283	CDD:416386	17/110 (15%)
		Ig strand A'	205..209	CDD:409353	3/17 (18%)
		Ig strand B	212..221	CDD:409353	2/8 (25%)
		Ig strand D	238..243	CDD:409353	0/4 (0%)
		Ig strand E	244..254	CDD:409353	1/9 (11%)
		Ig strand F	261..270	CDD:409353	3/27 (11%)
		Ig strand G	273..283	CDD:409353	3/9 (33%)
		IgI_TrkB_d5	286..379	CDD:409441	17/105 (16%)
		Ig strand B	301..305	CDD:409441	1/3 (33%)
		Ig strand C	314..318	CDD:409441	0/3 (0%)
		Ig strand E	344..348	CDD:409441	2/3 (67%)
		Ig strand F	358..363	CDD:409441	0/4 (0%)
		Ig strand G	371..374	CDD:409441	0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..514		6/22 (27%)
		PTKc_TrkB	548..835	CDD:270675	139/278 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810