DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and MUSK

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens

Alignment Length:	677	Identity:	200/677 - (29%)
Similarity:	307/677 - (45%)	Gaps:	170/677 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QQSSGICHIYNGTICRDVLS-NAHVFVSPNLTMNDLEERLK-AAYGVIKESKDMNANCRMYALPS 97
            :.:.|.|..|.|.:|..||: :|.||:  |.:..|.||..: ..:....|.|.::..||..|...
Human   321 KDNKGYCAQYRGEVCNAVLAKDALVFL--NTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEAL 383

  Fly    98 LCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTD 162
            ||                                                    :.|:::.....
Human   384 LC----------------------------------------------------NHIFQECSPGV 396

  Fly   163 ISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIG-------MVGVEDCQKLPQHK 220
            :.:..|          ||||.|..::...|.||:.:.:.....|       ::.|.:|.|||
Human   397 VPTPIP----------ICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLP--- 448

  Fly   221 DCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGS 285
                           :.:|:..:..|         .|.|.::  .:.:..||.:
Human   449 ---------------SMHWDPTACAR---------LPHLDYN--KENLKTFPPM----------- 476

  Fly   286 VENSPWCFVDSSRERIIELCDIPKCADKIWIAIVGTTAAIILIFIIIFAIILFKRRTIMHYGMRN 350
                      :|.:..:::.::|..:...:......:..:|:..:..|||.:....|.::...|.
Human   477 ----------TSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRR 531

  Fly   351 IHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALN----SKLIERNTLLRIN------HF 405
                           ....|..:::....|..|...:.|:    :.:.:|..|| :|      .:
Human   532 ---------------KQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLL-LNPKLLSLEY 580

  Fly   406 TLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKH 468
            ...::|::.::||||||:|::.:.  |.|.:....||:|.|||.||...|.||:||..|:::..:
Human   581 PRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 645

  Fly   469 QNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQ-------------------L 514
            .|||.:|||....:|.|:||||||.|||:|||.|.||....|||.                   .
Human   646 PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCA 710

  Fly   515 EFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLP 579
            |.|.||.|::.||.|||...:||||||.|||||.|.:||||:||||||:|||:|||:......:|
Human   711 EQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIP 775

  Fly   580 VRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTA 644
            :||||.|||.|.::|||||||::|||||||:|||:|||||.:::|||..:|...:||.|||||..
Human   776 IRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVE 840

  Fly   645 VYSLMIECWHEQSVKRPTFTDISNRLK 671
            :|:||..||.:....||:||.|...|:
Human   841 LYNLMRLCWSKLPADRPSFTSIHRILE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	37/197 (19%)
		KR	235..312	CDD:214527	8/76 (11%)
		PTKc_Ror	404..673	CDD:270642	141/289 (49%)
		Pkinase_Tyr	410..670	CDD:285015	140/280 (50%)
MUSK	XP_005252051.1	I-set	28..117	CDD:254352
		Ig	36..117	CDD:299845
		I-set	121..203	CDD:254352
		Ig	135..201	CDD:299845
		I-set	223..306	CDD:254352
		Ig	239..306	CDD:143165
		CRD_FZ	325..467	CDD:295308	41/234 (18%)
		PTKc_Musk	579..868	CDD:133181	141/289 (49%)
		Pkinase_Tyr	585..866	CDD:285015	140/280 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820