DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and Eph

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	198/738 - (26%)
Similarity:	314/738 - (42%)	Gaps:	193/738 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YSAFIVCISLVLLF-------------TKKDVGSHNVDSRIYG----FQQSSGICH---IYNGTI 48
            ||......:|.|||             .|.:..|...:|:||.    ::....||.   :||
  Fly   384 YSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYN--- 445

  Fly    49 CRDVLSNAHVFVSPNLTMNDLEE------RLKAAYGV--IKESKDMNANCRMYALPSLCFSSMPI 105
                 .:...|....:|:.:||.      ::.|...|  |.|.|..:....:.|:..:.||:
  Fly   446 -----PSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSN--- 502

  Fly   106 CRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPT 170
                  |:||   |:..:..::|        |...:|    :|..:|.:...||:..|.:
  Fly   503 ------TSLL---NIPLDLNEVK--------TGQAEI----VFTTESVLLSTVFNLRILA----- 541

  Fly   171 RESENLKRICREECELLENELCQKEYAI----AKRHPVIGMVGVEDCQKLPQHKDCLSLGITIEV 231
                    |..::.:|..::..|.::.:    .:..|.:.:..:.......:......:|:   :
  Fly   542 --------ITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGL---L 595

  Fly   232 DKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENSPWCFVDS 296
            :.||..:.....|..|..:.|                    .:|.....::.|||      :.||
  Fly   596 ENTEYGFQVRCKTNNGFGSYS--------------------NMIYAQTLQSVGSV------YDDS 634

  Fly   297 SRERIIELCDIPKCADKIWIAIVGTTAAII--LIFIIIF--AIILFKR---------RTIMHYGM 348
            .:.|.|                   ..||:  ::|::||  |.:.|.|         ::..|..:
  Fly   635 VQIRFI-------------------AGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPL 680

  Fly   349 ------------------RNIH-NINTPSADKNIYGNSQL----NNAQDAGRGNLGNLSDHVALN 390
                              :.:| |:.||     ::|||:.    :..:|.              |
  Fly   681 PLDYASNEVNSMDTTPIVKKLHLNVTTP-----LFGNSRSYVDPHTYEDP--------------N 726

  Fly   391 SKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL-LQPN-KTTITVAIKALKENASVKTQ 453
            ..:.|....:..|:.|::.:     :|.|.||.|.:|:| :.|| ...|.||||.||..:|.|.:
  Fly   727 QAIREFAREIDANYITIEAI-----IGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKAR 786

  Fly   454 QDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQ 518
            .||..|..::....|.|::.:.|||....|..::.|||.||.|..||..|   :|| ...|:.:.
  Fly   787 CDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVN---DGK-FQTLQLIV 847

  Fly   519 IALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDI-YSSDYYRVQSKSLLPVRW 582
            :...|:.||.|||..:||||||||||.|||..|:.||:||||||:| .:||.|..:. ..:||||
  Fly   848 MLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG-GKIPVRW 911

  Fly   583 MPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYS 647
            ...|:|.:.|||:.|||||:||||||:.|||.:||:.:|||:||..|.....|.||.:||.|:|.
  Fly   912 TAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQ 976

  Fly   648 LMIECWHEQSVKRPTFTDISNRL 670
            ||::||.:|...||||..|.:.|
  Fly   977 LMLDCWQKQRTHRPTFASIVSTL 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	33/203 (16%)
		KR	235..312	CDD:214527	12/76 (16%)
		PTKc_Ror	404..673	CDD:270642	121/270 (45%)
		Pkinase_Tyr	410..670	CDD:285015	119/262 (45%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	18/96 (19%)
		FN3	536..623	CDD:238020	12/122 (10%)
		EphA2_TM	644..736	CDD:291255	18/110 (16%)
		PTKc_EphR	736..1002	CDD:270629	122/274 (45%)
		Pkinase_Tyr	741..999	CDD:285015	120/267 (45%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455341
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940