Protein Alignment Ror and InR

DIOPT Version :9

• Sequence 1: NP_476962.1
• Gene: Ror / 34367
• FlyBaseID: FBgn0010407
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: NP_001138093.1
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 163/618 - (26%)
• Similarity: 285/618 - (46%)
• Gaps: 128/618 - (20%)

  Fly    81 KESKDMNANCRMYALPSLCFSSMPICRTPERTNLLYFANVATNAKQLKN-------VSIRRKRTK 138
            |:.:|:::|.:.|   .:....:|    |.:|:.::        ::|::       |...|:...
  Fly  1125 KDEEDLSSNKQFY---EVFAKELP----PNQTHFVF--------EKLRHFTRYAIFVVACREEIP 1174

  Fly   139 SKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHP 203
            |:.:::.|..|...:.|:.||.|....|:                .:::.:.....|:|.....|
  Fly  1175 SEKLRDTSFKKSLCSDYDTVFQTTKRKKF----------------ADIVMDLKVDLEHANNTESP 1223

  Fly   204 VIGMVGVEDCQKLPQHKDCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEI 268
                |.|.....:..:.:.::..:..::.|.:                ....|.|:       ..
  Fly  1224 ----VRVRWTPPVDPNGEIVTYEVAYKLQKPD----------------QVEEKKCI-------PA 1261

  Fly   269 SDFPELIGQNYCRNPGSVE-----NSPWCFVDSSRERIIELCDIPKCADKIWIAIVGTTAAIILI 328
            :||.:..|.....|.|...     ||...:.|.:....|::...|..| |::..::|...|.:::
  Fly  1262 ADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYA-KVFFWLLGIGLAFLIV 1325

  Fly   329 FIIIFAIILFKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKL 393
            .:..:...|.||:              .||.|  ::.|:::|....:        ..::..:.::
  Fly  1326 SLFGYVCYLHKRK--------------VPSND--LHMNTEVNPFYAS--------MQYIPDDWEV 1366

  Fly   394 IERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKENASVKTQQDF 456
            :..|.:.            |..||:|:||.||:|.|  ..||......|||.:.|||:.:.:.:|
  Fly  1367 LRENIIQ------------LAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNF 1419

  Fly   457 KREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFL---- 517
            ..|..::.:....::|.:|||....:|..::.|.|..|||..:|.::.|.| :..:.:.:|
  Fly  1420 LSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEE-RDEAMMTYLNRIG 1483

  Fly   518 --------------QIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSD 568
                          |:|::|::||.||:|..:||||||||||:|.:.|.|||.|||::||||.:|
  Fly  1484 VTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD 1548

  Fly   569 YYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQ 633
            |||..:|.||||||||.||:..|.:::.|||:||||||||:.:...|||.|.||::|:..:....
  Fly  1549 YYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGG 1613

  Fly   634 LLSAPENCPTAVYSLMIECWHEQSVKRPTFTDI 666
            ::..|||||..::.||..|||.:|..||:|.||
  Fly  1614 VMERPENCPDFLHKLMQRCWHHRSSARPSFLDI 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	23/153 (15%)
		KR	235..312	CDD:214527	12/81 (15%)
		PTKc_Ror	404..673	CDD:270642	114/283 (40%)
		Pkinase_Tyr	410..670	CDD:285015	114/277 (41%)
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020	14/100 (14%)
		PTKc_InsR_like	1364..1652	CDD:173625	115/296 (39%)
		Pkinase_Tyr	1371..1650	CDD:285015	114/289 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940