Protein Alignment Ror and Egfr

DIOPT Version :10

• Sequence 1: NP_476962.1
• Gene: Ror / 34367
• FlyBaseID: FBgn0010407
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 703
• Identity: 165/703 - (23%)
• Similarity: 277/703 - (39%)
• Gaps: 188/703 - (26%)

  Fly    44 YNGTICRD--VLSNAHVFVSPNLTMNDLEERLKAAYGV----------IKESKDMNANCRMYALP 96
            :|||...|  .:|||:.|  .|.|........:...|.          :::.:...:.|     |
  Fly   598 FNGTCIADCGYISNAYKF--DNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSEC-----P 655

  Fly    97 SLCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFST 161
            ...::...:||....|     .:..|..|.  .:.|....|.:..|.|.....|:..:.:|....
  Fly   656 KNKYNDRGVCRECHAT-----CDGCTGPKD--TIGIGACTTCNLAIINNDATVKRCLLKDDKCPD 713

  Fly   162 DISSKYPPTRESENLK--------RICREECELLEN-----ELCQKEYAIAKRHPVIGMVGVEDC 213
            ....:|...:|..:||        |.|...|||..|     ::|.|                  |
  Fly   714 GYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSK------------------C 760

  Fly   214 QKLPQHKDCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQN 278
            ....:.:.|       |.:...:.|.::            ..:.|.:.         .||.   |
  Fly   761 THYKRREQC-------ETECPADHYTDE------------EQRECFQC---------HPEC---N 794

  Fly   279 YCRNPGSVE------------NSPWCFVDSSRERIIELCDI-------------PKCA------- 311
            .|..||:.:            |....:|:|:.......|.:             |.||
  Fly   795 GCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSS 859

  Fly   312 ------DKIWIAIVGTTAAIILIFIIIFAIILF--------KRRTIMHYGMRNIHNINTPSADKN 362
                  |...|.|:  |.|:::..|.|..::.:        |:.|:                 |.
  Fly   860 KITANLDVNMIFII--TGAVLVPTICILCVVTYICRQKQKAKKETV-----------------KM 905

  Fly   363 IYGNSQLNNAQDAGRGNLG-NLSDHVALNSKLIERNTLLRINHFTLQDVEFLE--ELGEGAFGKV 424
            ....|...:::.....|:| ||..              |||    ::|.|..:  .||.||||:|
  Fly   906 TMALSGCEDSEPLRPSNIGANLCK--------------LRI----VKDAELRKGGVLGMGAFGRV 952

  Fly   425 YKGQLL-QPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLF 488
            |||..: :.....|.||||.|.::...::.::|.||..:::.::|.|::.:|.|.::.: ..::.
  Fly   953 YKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLIT 1016

  Fly   489 EYMANGDLHEFLISNSPTEG-KSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLV 552
            :.|..|.|.:::.:|....| |:|     |..:.||::||.||.....|||||||||.||....:
  Fly  1017 QLMPLGCLLDYVRNNRDKIGSKAL-----LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSL 1076

  Fly   553 VKISDFGLSRDIYSSD---YYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGM 614
            |||:||||:: :.|||   |.....|  :|::|:..|.|....||::||||:|||.:||:.::|.
  Fly  1077 VKITDFGLAK-LLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQ 1138

  Fly   615 QPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDIS 667
            :|:.....:::.:||.....|..||.|...:|..::.|||..:..||||..::
  Fly  1139 RPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLT 1191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	38/208 (18%)
		KR	235..312	CDD:214527	15/114 (13%)
		PTKc_Ror	404..673	CDD:270642	93/271 (34%)
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344	18/99 (18%)
		FU	662..716	CDD:214589	11/60 (18%)
		GF_recep_IV	740..>834	CDD:464344	21/142 (15%)
		PTKc_EGFR_like	930..1208	CDD:270648	96/275 (35%)