DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and Egfr

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	165/703 - (23%)
Similarity:	277/703 - (39%)	Gaps:	188/703 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YNGTICRD--VLSNAHVFVSPNLTMNDLEERLKAAYGV----------IKESKDMNANCRMYALP 96
            :|||...|  .:|||:.|  .|.|........:...|.          :::.:...:.|     |
  Fly   598 FNGTCIADCGYISNAYKF--DNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSEC-----P 655

  Fly    97 SLCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFST 161
            ...::...:||....|     .:..|..|.  .:.|....|.:..|.|.....|:..:.:|....
  Fly   656 KNKYNDRGVCRECHAT-----CDGCTGPKD--TIGIGACTTCNLAIINNDATVKRCLLKDDKCPD 713

  Fly   162 DISSKYPPTRESENLK--------RICREECELLEN-----ELCQKEYAIAKRHPVIGMVGVEDC 213
            ....:|...:|..:||        |.|...|||..|     ::|.|                  |
  Fly   714 GYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSK------------------C 760

  Fly   214 QKLPQHKDCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQN 278
            ....:.:.|       |.:...:.|.::            ..:.|.:.         .||.   |
  Fly   761 THYKRREQC-------ETECPADHYTDE------------EQRECFQC---------HPEC---N 794

  Fly   279 YCRNPGSVE------------NSPWCFVDSSRERIIELCDI-------------PKCA------- 311
            .|..||:.:            |....:|:|:.......|.:             |.||
  Fly   795 GCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSS 859

  Fly   312 ------DKIWIAIVGTTAAIILIFIIIFAIILF--------KRRTIMHYGMRNIHNINTPSADKN 362
                  |...|.|:  |.|:::..|.|..::.:        |:.|:                 |.
  Fly   860 KITANLDVNMIFII--TGAVLVPTICILCVVTYICRQKQKAKKETV-----------------KM 905

  Fly   363 IYGNSQLNNAQDAGRGNLG-NLSDHVALNSKLIERNTLLRINHFTLQDVEFLE--ELGEGAFGKV 424
            ....|...:::.....|:| ||..              |||    ::|.|..:  .||.||||:|
  Fly   906 TMALSGCEDSEPLRPSNIGANLCK--------------LRI----VKDAELRKGGVLGMGAFGRV 952

  Fly   425 YKGQLL-QPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLF 488
            |||..: :.....|.||||.|.::...::.::|.||..:::.::|.|::.:|.|.::.: ..::.
  Fly   953 YKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLIT 1016

  Fly   489 EYMANGDLHEFLISNSPTEG-KSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLV 552
            :.|..|.|.:::.:|....| |:|     |..:.||::||.||.....|||||||||.||....:
  Fly  1017 QLMPLGCLLDYVRNNRDKIGSKAL-----LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSL 1076

  Fly   553 VKISDFGLSRDIYSSD---YYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGM 614
            |||:||||:: :.|||   |.....|  :|::|:..|.|....||::||||:|||.:||:.::|.
  Fly  1077 VKITDFGLAK-LLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQ 1138

  Fly   615 QPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDIS 667
            :|:.....:::.:||.....|..||.|...:|..::.|||..:..||||..::
  Fly  1139 RPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLT 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	38/208 (18%)
		KR	235..312	CDD:214527	15/114 (13%)
		PTKc_Ror	404..673	CDD:270642	93/271 (34%)
		Pkinase_Tyr	410..670	CDD:285015	92/265 (35%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382
		GF_recep_IV	572..684	CDD:291509	18/99 (18%)
		FU	573..>606	CDD:238021	3/7 (43%)
		FU	617..659	CDD:214589	5/46 (11%)
		FU	662..716	CDD:214589	11/60 (18%)
		FU	739..786	CDD:238021	11/83 (13%)
		FU	784..834	CDD:214589	10/61 (16%)
		PTKc_EGFR_like	930..1208	CDD:270648	96/275 (35%)
		STYKc	938..1194	CDD:214568	91/263 (35%)
		Recep_L_domain	128..239	CDD:279382
		Furin-like	253..401	CDD:279142
		FU	255..292	CDD:214589
		FU	302..345	CDD:238021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455333
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940