DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and Nrk

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	228/767 - (29%)
Similarity:	347/767 - (45%)	Gaps:	178/767 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KYSAFIVCISL-VLLF----------------TKKDVGSHNVDSRIYGFQQSSGICHIYNGTICR 50
            |:.|.:..:.| |.||                |::....|:...|     :.:|.|..|:|.:|:
  Fly    20 KWGANLAVLGLCVFLFASATHANSLNAIEEPVTRRHHQRHHERER-----EENGYCAPYSGKVCK 79

  Fly    51 DVLSNAHVFVSPNLTMNDLEERLKAAY--GVIKESKDMNANCRMYALPSLCFSSMPICRTPERTN 113
            :.|:....:...:.|.....|::..|.  .:|   .|:...||..|...||..:.|.|.
  Fly    80 EYLTGQVWYSLEDPTGGWKNEQVTTALWDELI---SDLTGLCREAAEKMLCAYAFPNCH------ 135

  Fly   114 LLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKR 178
                                                         .....:.|.|
  Fly   136 ---------------------------------------------MEGGRAVKAP---------- 145

  Fly   179 ICREECELLENELCQKEYAI----AKRHPVI---GMVGVEDCQKLPQHK------DCLSLGITIE 230
            :|.|:|:....:.|..::.:    .:|:..|   |...:.:|..||.:.      :|..:|:| |
  Fly   146 LCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLT-E 209

  Fly   231 VDKTE---NCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELI------GQNYCRNPGSV 286
            :.::|   :|...:|..|.|..|||.||.||.||..........|.|:      |:|||||.|..
  Fly   210 LKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGE 274

  Fly   287 ENSPWCF-VDSSRERIIELCDIPKCADKI-----------------------WIAIVGTTAAIIL 327
            |..|||: ||.|..  .:.||||.|.|.:                       .:|.:|..|.:.|
  Fly   275 EPHPWCYTVDESVR--WQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTL 337

  Fly   328 IFIIIFAIILFKRRTIMHYGMRNIHNINTPSADKNIYG----NSQLNNAQD--AGRGNLGNL--- 383
            ..:|:....|.|     |..........|.....::.|    ...||.:::  .|.||...|
  Fly   338 HLMILLVYKLSK-----HKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKW 397

  Fly   384 ----------SDHVAL-------NSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL-- 429
                      |:.|||       ::|..:.|..|....:...|:.::..||:||||:|::.:.
  Fly   398 GTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPG 462

  Fly   430 LQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANG 494
            |.|::..:.||:|.||::||.:.|.||:||..|:::..|.|||.:|||.....|.|:||||||.|
  Fly   463 LVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPG 527

  Fly   495 DLHEFL-------ISNSPTEGK-SLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGL 551
            ||.|||       ...:||:.: .|::|..||:|..|:.||.|||...:||||||.||||:||.:
  Fly   528 DLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHM 592

  Fly   552 VVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQP 616
            .|||:|||||..||..|||:......:|:||||.|||||.||:.|||||::|:.|||::|:.:||
  Fly   593 AVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQP 657

  Fly   617 YYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISN 668
            |:|.:::|||..|:...:|..|:|.|.:||:||..||:.:..:||.|.:|::
  Fly   658 YFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINH 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	32/203 (16%)
		KR	235..312	CDD:214527	35/86 (41%)
		PTKc_Ror	404..673	CDD:270642	126/275 (46%)
		Pkinase_Tyr	410..670	CDD:285015	125/269 (46%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	34/209 (16%)
		KR	217..299	CDD:214527	34/83 (41%)
		PTKc_Musk	435..713	CDD:133181	126/275 (46%)
		Pkinase_Tyr	441..707	CDD:285015	124/265 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455362
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	1	0.900	-	-		E2759_KOG1026
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I2087
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14447
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900