Protein Alignment Ror and sev

DIOPT Version :10

• Sequence 1: NP_476962.1
• Gene: Ror / 34367
• FlyBaseID: FBgn0010407
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Alignment Length: 744
• Identity: 209/744 - (28%)
• Similarity: 310/744 - (41%)
• Gaps: 180/744 - (24%)

  Fly    62 PNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSLCFSSMPICRTPE--RTNLLYFANVATNA 124
            |.|.:..||....:|    ..|...|.:.|:.:...|..|.:|    ||  |:..:|:.......
  Fly  1783 PTLVLAPLELLTASA----TPSPPRNFSVRVLSPRELEVSWLP----PEQLRSESVYYTLHWQQE 1839

  Fly   125 KQLKNVSIRR------KRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREE 183
            ...:||..||      :|.::.....::..|..|.     :|..:.:...||:.:.:.:...|..
  Fly  1840 LDGENVQDRREWEAHERRLETAGTHRLTGIKPGSG-----YSLWVQAHATPTKSNSSERLHVRSF 1899

  Fly   184 CELLENELCQ------------------------KEYAIAKRHPVIG----MVGVEDCQKLPQHK 220
            .||.|.:|.:                        :..|...|..|.|    || ||..|...:::
  Fly  1900 AELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMV-VEPLQPRTRYQ 1963

  Fly   221 DCLSLGITIEVDKTENCYWEDGSTYRGVANV--------SASGKPCL--------RWSW------ 263
            ..|.||....         .....|.|.|.|        |..|||.|        |.:|
  Fly  1964 CRLLLGYAAT---------PGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGN 2019

  Fly   264 ----------LMKEISDFPELIGQNYCRNPGSVENSPW---------------------CFV--- 294
                      .::..||......:....:.||:|..||                     |.|
  Fly  2020 GAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSL 2084

  Fly   295 DSSR----------------------ERIIELCDIPKCADKIWIAIVGTTAAIILIFIIIFAIIL 337
            .|||                      ||:.|....|:....:.:||:...|   ::...:.|::|
  Fly  2085 HSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAA---IVSSCVLALVL 2146

  Fly   338 FKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQD----AGRGNLGNLSD-HVALNSKLIERN 397
            .::........:.:...:.||...|:   |.|...|.    ..|.....||| .:||
  Fly  2147 VRKVQKRRLRAKKLLQQSRPSIWSNL---STLQTQQQLMAVRNRAFSTTLSDADIAL-------- 2200

  Fly   398 TLLRINHFTLQDVEFLEELGEGAFGKVYKGQL-LQPNKTTITVAIKALKENASVKTQQDFKREIE 461
             |.:||...|:.:.|   ||.||||:||:||| .:.::....||||:|::.||  ...:..:|.:
  Fly  2201 -LPQINWSQLKLLRF---LGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGAS--EFAELLQEAQ 2259

  Fly   462 LISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLIS--------NSPTEGKSLSQLEFLQ 518
            |:|:.||:||||::|:..:.|...::.|:|..|||..:|.:        ..||.|.|||:|  |.
  Fly  2260 LMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSEL--LA 2322

  Fly   519 IALQISEGMQYLSAHHYVHRDLAARNCLVNEGL-------VVKISDFGLSRDIYSSDYYRVQSKS 576
            :.:.::.|..||...|:||||||.|||||.|..       .|||.||||:||||.|||||.:.:.
  Fly  2323 MCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEG 2387

  Fly   577 LLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENC 641
            |||||||..||::.|.|||:||||:|||:.|||.:.|.|||...:|.||:..::....|..|..|
  Fly  2388 LLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMC 2452

  Fly   642 PTAVYSLMIECWHEQSVKRPTFTDISNRL 670
            ...:|||::.||.....:||:|....|.|
  Fly  2453 TEKLYSLLLLCWRTDPWERPSFRRCYNTL 2481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	42/201 (21%)
		KR	235..312	CDD:214527	27/154 (18%)
		PTKc_Ror	404..673	CDD:270642	120/283 (42%)
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	20/99 (20%)
		FN3	1993..2111	CDD:238020	19/117 (16%)
		PTKc_c-ros	2213..2483	CDD:270640	119/276 (43%)