DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ror and Ntrk3

DIOPT Version :9

Sequence 1:NP_476962.1 Gene:Ror / 34367 FlyBaseID:FBgn0010407 Length:685 Species:Drosophila melanogaster
Sequence 2:NP_001257585.1 Gene:Ntrk3 / 29613 RGDID:3214 Length:864 Species:Rattus norvegicus


Alignment Length:645 Identity:193/645 - (29%)
Similarity:295/645 - (45%) Gaps:182/645 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 VATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREEC 184
            :|.|...:.|.|:                  ..|:|           |||...|           
  Rat   285 IAENVVGMSNASV------------------ALTVY-----------YPPRVVS----------- 309

  Fly   185 ELLENELCQKEYAI---AKRHPVIGMVGVEDCQKLPQHKDCLSLGITIEVDKTENC-------YW 239
             |:|.|: :.|:.|   .:.:|...:..:.:.|.|.:.| .:.:....|.:.:|.|       ::
  Rat   310 -LVEPEV-RLEHCIEFVVRGNPTPTLHWLYNGQPLRESK-IIHMDYYQEGEVSEGCLLFNKPTHY 371

  Fly   240 EDGS------TYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENSPWCFVDSSR 298
            .:|:      ...|.||.:.:|.       .:||  .|||  ..::.........:|...|....
  Rat   372 NNGNYTLIAKNALGTANQTINGH-------FLKE--PFPE--STDFFDFESDASPTPPITVTHKP 425

  Fly   299 ERIIELCDIPKCADKIWIAI-VGTTAAIILIFIIIFAII-LFKRRTIMHYGMRN----------- 350
            |.           |...::| ||..|...::.:::|.:| .:.||:  .:||:.           
  Rat   426 EE-----------DTFGVSIAVGLAAFACVLLVVLFIMINKYGRRS--KFGMKGPVAVISGEEDS 477

  Fly   351 ---IHNIN----TPSA-----DKNIYGNSQ---LNNAQDAGRGNLGNLSDHVALNSKLIERNTLL 400
               :|:||    |||:     |..:.|.::   :.|.|...:|:..:..|              .
  Rat   478 ASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPD--------------T 528

  Fly   401 RINHFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKENASVKTQQDFKREIELI 463
            .:.|...:|:....||||||||||:..:.  |.|.|..:.||:||||: .::..::||:||.||:
  Rat   529 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD-PTLAARKDFQREAELL 592

  Fly   464 SDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEF----------LISNSPTEGK---SLSQLE 515
            ::|:|::||...||..:.:|..|:||||.:|||::|          |:...|.:.|   .|||: 
  Rat   593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQM- 656

  Fly   516 FLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYR--------- 571
             |.||.||:.||.||::.|:||||||.|||||...|:|||.|||:|||:||:||||         
  Rat   657 -LHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPYQKGPF 720

  Fly   572 ------------------------------VQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVL 606
                                          |...::||:||||.|||:|.|||||||||||||:|
  Rat   721 SVSWQQQRLAASAASTLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 785

  Fly   607 WEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDI 666
            |||::||.||::..||.|||..|...::|..|..||..||.:|:.||..:..:|....:|
  Rat   786 WEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RorNP_476962.1 CRD_TK_ROR_like 39..228 CDD:143568 19/110 (17%)
KR 235..312 CDD:214527 15/89 (17%)
PTKc_Ror 404..673 CDD:270642 135/317 (43%)
Pkinase_Tyr 410..670 CDD:285015 133/311 (43%)
Ntrk3NP_001257585.1 LRRNT 31..>51 CDD:396168
LRR_8 103..160 CDD:404697
LRR 1 104..125
leucine-rich repeat 105..128 CDD:275378
LRR 2 128..149
leucine-rich repeat 129..151 CDD:275378
leucine-rich repeat 152..164 CDD:275378
TPKR_C2 163..208 CDD:407151
ig 214..299 CDD:395002 4/31 (13%)
Ig strand A' 218..221 CDD:409353
Ig strand B 226..234 CDD:409353
Ig strand C 240..244 CDD:409353
Ig strand D 254..262 CDD:409353
Ig strand E 266..271 CDD:409353
Ig strand F 279..288 CDD:409353 1/2 (50%)
Ig strand G 291..301 CDD:409353 2/27 (7%)
IgI_TrKABC_d5 304..396 CDD:409360 20/112 (18%)
Ig strand B 319..323 CDD:409360 1/3 (33%)
Ig strand C 332..336 CDD:409360 0/3 (0%)
Ig strand E 361..365 CDD:409360 1/3 (33%)
Ig strand F 375..380 CDD:409360 0/4 (0%)
Ig strand G 388..391 CDD:409360 1/2 (50%)
PTKc_TrkC 532..857 CDD:270676 135/317 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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