DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and Ror1

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_038873.2	Gene:	Ror1 / 26563	MGIID:	1347520	Length:	937	Species:	Mus musculus

Alignment Length:	696	Identity:	259/696 - (37%)
Similarity:	361/696 - (51%)	Gaps:	147/696 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QSSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSLCF 100
            :..|.|..|.|..|...:.|..|::.......::|.::.||:.:|..|..::..|..:|:||||.
Mouse   165 EEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCH 229

  Fly   101 SSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISS 165
            .:.|.|                                                       |.:|
Mouse   230 YAFPYC-------------------------------------------------------DETS 239

  Fly   166 KYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGM-VGVEDCQKLPQHK-----DCLS 224
            ..|..|:      :||:|||:|||.|||.||..|:.:|:|.| :.:.:|:.|||.:     :|:.
Mouse   240 SVPKPRD------LCRDECEVLENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIR 298

  Fly   225 LGITI--EVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISD-----FPELI-GQNYCR 281
            :||.:  .::|...||...|..|||..:|:.||:.|..|:........     ||||. |.:|||
Mouse   299 IGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGGHSYCR 363

  Fly   282 NPGSVENSPWCF-VDSSRERIIELCDIPKCADK----------IWIAIVGTTAAIILIFIIIFAI 335
            |||:.:.:|||| :|.:.:.  :|||||.|..|          ::|.:......:.:.|:..|..
Mouse   364 NPGNQKEAPWCFTLDENFKS--DLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAFLFFFIC 426

  Fly   336 ILFKRRTIMHYGMRNIHNINTPSAD---KNIYGN----SQLNNAQDAGRGNLGNLSDHVALNSKL 393
            :           .||....::|...   |.:.|.    |.||..:...:.
Mouse   427 V-----------CRNNQKSSSPPVQRQPKPVRGQNVEMSMLNAYKPKSKA--------------- 465

  Fly   394 IERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQLLQPNKT-TITVAIKALKENASVKTQQDFK 457
                     ....|..|.|:|||||..|||:|||.|..|... ...||||.||:..:.:...:|:
Mouse   466 ---------KELPLSAVRFMEELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQ 521

  Fly   458 REIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSP------------TEGKS 510
            :|..|:::|.|.||||:||.|..::|.|||||||..||||||||..||            |...|
Mouse   522 QEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSS 586

  Fly   511 LSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSK 575
            |...:||.||:||:.||:|||:|.:||:||||||.|:.|.|.|||||.||||:|||:||||||||
Mouse   587 LDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSK 651

  Fly   576 SLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPEN 640
            |.||:||||.|:|:||||:::||:||||||||||:|:|:||||||||||||.::|.||||...|:
Mouse   652 SSLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSED 716

  Fly   641 CPTAVYSLMIECWHEQSVKRPTFTDISNRLKTWHEG---HFKASNP 683
            ||..:||||.|||:|...:||.|.||..||::| ||   |..::.|
Mouse   717 CPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSW-EGLSSHTSSTTP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	47/194 (24%)
		KR	235..312	CDD:214527	33/83 (40%)
		PTKc_Ror	404..673	CDD:270642	160/281 (57%)
		Pkinase_Tyr	410..670	CDD:285015	157/272 (58%)
Ror1	NP_038873.2	I-set	63..148	CDD:254352
		Ig	75..143	CDD:143165
		CRD_TK_ROR1	166..307	CDD:143576	48/201 (24%)
		KR	311..393	CDD:214527	33/83 (40%)
		PTKc_Ror1	467..749	CDD:270672	160/281 (57%)
		Pkinase_Tyr	473..746	CDD:285015	157/272 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..778		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..890
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..937
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1223
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3675
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48666
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	1	1.000	-	-		FOG0003730
OrthoInspector	1	1.000	-	-		otm43474
orthoMCL	1	0.900	-	-		OOG6_105406
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3136
SonicParanoid	1	1.000	-	-		X2586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870