DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ror and Ntrk2

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	XP_008769647.1	Gene:	Ntrk2 / 25054	RGDID:	3213	Length:	837	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	216/755 - (28%)
Similarity:	344/755 - (45%)	Gaps:	171/755 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FIVCISLVLLFTKKDVGSHNVDSRIYGFQQSSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEE 71
            |.....::.|.|.::..|......:|...:||....:.|..|....|.:|.: .:||||
  Rat   150 FTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARL-AAPNLT------ 207

  Fly    72 RLKAAYGVIKESKDMNANCRMYA--LPSLCFS-----SMPICRTPERTNLLYFANVAT--NAKQL 127
                    ::|.|.:..:|.:..  ||:|.:.     |..:..|......|...|:::  :.||:
  Rat   208 --------VEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQI 264

  Fly   128 KNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREECELLENELC 192
            ..|:                   ::.:.||..|.:::..:.||             ...||:...
  Rat   265 SCVA-------------------ENLVGEDQDSVNLTVHFAPT-------------ITFLESPTS 297

  Fly   193 QKEYAI-----AKRHPVI-----GMVGVED---CQKL-----PQHKDCLSLGITIEVDK------ 233
            ...:.|     ....|.:     |.:..|.   |.|:     .::..||.|.....::.
  Rat   298 DHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLM 362

  Fly   234 TENCYWED----GSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENSPWCFV 294
            .:|.|.:|    .:.:.|...|.....|            ::||::.::: ..|..:.::
  Rat   363 AKNEYGKDERQISAHFMGRPGVDYETNP------------NYPEVLYEDW-TTPTDIGDT----- 409

  Fly   295 DSSRERIIELCDIPKCADKIWIAIVGTTA-AIILIFIIIFAIILFKRRTIMHYGMRNI------- 351
             :::...|...|:....::..:::..... |.::.|.::..::|.|......:||:::
  Rat   410 -TNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKDVSWFGIGK 473

  Fly   352 -----------------------HNI----NTPSA-----DKNIYGNSQ---LNNAQDAGRGNLG 381
                                   |:|    ||||:     |..|.|.::   :.|.|..|
  Rat   474 VKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFG----- 533

  Fly   382 NLSDHVALNSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKAL 444
                  ..||:| :.:|.  :.|....::....||||||||||:..:.  |.|.:..|.||:|.|
  Rat   534 ------ITNSQL-KPDTF--VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTL 589

  Fly   445 KENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSP---- 505
            |: ||...::||.||.||:::|:|::||...||.:..:|..|:||||.:|||::||.::.|
  Rat   590 KD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVL 653

  Fly   506 -TEGK---SLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYS 566
             .||.   .|:|.:.|.||.||:.||.||::.|:||||||.|||||.|.|:|||.|||:|||:||
  Rat   654 MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 718

  Fly   567 SDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRS 631
            :|||||...::||:||||.|||:|.||||||||||.|||||||::||.||:|..||.|||..|..
  Rat   719 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 783

  Fly   632 RQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRLK 671
            .::|..|..||..||.||:.||..:...|....:|...|:
  Rat   784 GRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQ 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	37/215 (17%)
		KR	235..312	CDD:214527	11/80 (14%)
		PTKc_Ror	404..673	CDD:270642	139/278 (50%)
		Pkinase_Tyr	410..670	CDD:285015	137/269 (51%)
Ntrk2	XP_008769647.1	LRR_8	92..150	CDD:404697	216/755 (29%)
		TPKR_C2	152..195	CDD:407151	8/42 (19%)
		Ig	205..283	CDD:416386	19/110 (17%)
		Ig strand A'	205..209	CDD:409353	3/17 (18%)
		Ig strand B	212..221	CDD:409353	2/8 (25%)
		Ig strand D	238..243	CDD:409353	0/4 (0%)
		Ig strand E	244..254	CDD:409353	1/9 (11%)
		Ig strand F	261..270	CDD:409353	3/27 (11%)
		Ig strand G	273..283	CDD:409353	3/9 (33%)
		IgI_TrkB_d5	286..379	CDD:409441	16/105 (15%)
		Ig strand B	301..305	CDD:409441	1/3 (33%)
		Ig strand C	314..318	CDD:409441	0/3 (0%)
		Ig strand E	344..348	CDD:409441	2/3 (67%)
		Ig strand F	358..363	CDD:409441	0/4 (0%)
		Ig strand G	371..374	CDD:409441	0/2 (0%)
		PTKc_TrkB	547..834	CDD:270675	139/278 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810