DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ror and musk

DIOPT Version :9

Sequence 1:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	XP_012808865.1	Gene:	musk / 100485502	XenbaseID:	XB-GENE-923007	Length:	950	Species:	Xenopus tropicalis

Alignment Length:	730	Identity:	234/730 - (32%)
Similarity:	336/730 - (46%)	Gaps:	178/730 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RIYGFQQSSGICHIYNGTICRDVLSNAHV--FVSPNLTMNDLEERLKAAYGVIKESKDMNANCRM 92
            |:|  :...|.|..|.|.:|..||:...:  |.|.|....:.:|.|  |.....|.|.:::.||.
Frog   307 RLY--KGDGGYCSTYRGDVCSSVLAKDSLVFFNSSNAEPEESQEML--AQTTWNELKTVSSFCRP 367

  Fly    93 YALPSLCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYED 157
            .|...||......|.
Frog   368 AAEAFLCNYFFQECN-------------------------------------------------- 382

  Fly   158 VFSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIG-------MVGVEDCQK 215
                       ||.|....|.:|||.|..:::..|.|::...:.:...|       ::.:.||.|
Frog   383 -----------PTGEGPTPKPMCREHCLAVKDLYCFKDWLSMEENSRKGIYKHGLMLLALPDCDK 436

  Fly   216 LPQ----HKDCLSLGITIEVDK---TENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEI----- 268
            ||:    .|.|..:.. .|:.|   |..||..:|..|:|..|.:.||.||.:||..:..:
Frog   437 LPRIQNNPKVCTRIPF-FELHKENITRTCYKGNGRHYQGSINTTTSGIPCQKWSQQLPHLHRRLP 500

  Fly   269 SDFPELI-GQNYCRNPGSVENSPWCFVDSSRERIIELCDIPKC---------------------- 310
            ..||||. ..|:|||||.....|||:......| .|.|::|.|
Frog   501 EVFPELSNSDNHCRNPGGESERPWCYTTDPNVR-WEYCNVPLCGTSAANFPVTTKTAFGPPVMPS 564

  Fly   311 -------ADKIWIAIVGTTAAIILIFIIIFAIILFKRRTIMHYGMRNIHNINTPSADKNIYGNSQ 368
                   |..:.:.|...:....:||::|..:|..:|:                         .:
Frog   565 TSSSFSPAHSMTVIISTISICAAMIFVLIAGLICCRRQ-------------------------KK 604

  Fly   369 LNNA-QDAGRGNLGNLSDHVALN----SKLIERNTLLRINH------FTLQDVEFLEELGEGAFG 422
            |||. ::|....|..|...:.|:    :.:.:|..|| :||      :...::|::.::||||||
Frog   605 LNNKNREAAAPTLTALPSELLLDRLHPNPMYQRMPLL-LNHKLLNLEYPRNNIEYVRDIGEGAFG 668

  Fly   423 KVYKGQ---LLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPY 484
            :|::.:   ||.....|: ||:|.|||.||...|.||:||..|:::..|.|||.:|||....:|.
Frog   669 RVFQARAPGLLSYEPFTM-VAVKMLKEEASADMQADFQREAALMAEFDHPNIVKLLGVCAVGKPM 732

  Fly   485 CMLFEYMANGDLHEFLISNSPTEGKSLSQ-------------------LEFLQIALQISEGMQYL 530
            |:||||||:|||:|:|...||....|||.                   .:.|.||.|::.||.||
Frog   733 CLLFEYMAHGDLNEYLRHRSPRALSSLSHSSLAAKVRLCDLNPSPLSCTDQLCIARQVAAGMAYL 797

  Fly   531 SAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTT 595
            |...:||||||.|||||.|.:||||:||||||:|||:|||:......:|:||||.|||.|.::||
Frog   798 SERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTT 862

  Fly   596 ESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKR 660
            |||||::|||||||:|||||||||.:::|||..:|...:||.|||||..:|:||..||.:....|
Frog   863 ESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNILSCPENCPLELYNLMRLCWSKMPSDR 927

  Fly   661 PTFTDISNRLKTWHE 675
            |:|..|...|:..:|
Frog   928 PSFACIYRILERMYE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	39/201 (19%)
		KR	235..312	CDD:214527	30/111 (27%)
		PTKc_Ror	404..673	CDD:270642	141/296 (48%)
		Pkinase_Tyr	410..670	CDD:285015	139/281 (49%)
musk	XP_012808865.1	Ig	28..117	CDD:386229
		I-set	121..208	CDD:369462
		Ig	215..303	CDD:386229
		CRD_FZ	312..457	CDD:382974	40/208 (19%)
		KR	462..543	CDD:214527	29/81 (36%)
		PTKc_Musk	650..939	CDD:133181	140/289 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920