DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment me31B and DHH1

DIOPT Version :9

Sequence 1:	NP_523533.2	Gene:	me31B / 34364	FlyBaseID:	FBgn0004419	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_010121.1	Gene:	DHH1 / 851394	SGDID:	S000002319	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	426	Identity:	284/426 - (66%)
Similarity:	342/426 - (80%)	Gaps:	11/426 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NSGHTNLTSKGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLM 71
            |:.:||..|           ||..|..||:.|.:|.||.|.:|.||.:|:||.||:|.|||||||
Yeast     6 NNFNTNNNS-----------NTDLDRDWKTALNIPKKDTRPQTDDVLNTKGNTFEDFYLKRELLM 59

  Fly    72 GIFEKGWERPSPIQEAAIPIALSGKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTR 136
            ||||.|:|:||||||.|||:|::|:|:|||||||||||.|:.||.||::.|..:.||||:|||||
Yeast    60 GIFEAGFEKPSPIQEEAIPVAITGRDILARAKNGTGKTAAFVIPTLEKVKPKLNKIQALIMVPTR 124

  Fly   137 ELALQTSQICIELAKHLDIRVMVTTGGTILKDDILRIYQKVQLIIATPGRILDLMDKKVADMSHC 201
            ||||||||:...|.||..|..|||||||.|:|||||:.:.|.:::.||||:|||..:||||:|.|
Yeast   125 ELALQTSQVVRTLGKHCGISCMVTTGGTNLRDDILRLNETVHILVGTPGRVLDLASRKVADLSDC 189

  Fly   202 RILVLDEADKLLSLDFQGMLDHVILKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINLMEELT 266
            .:.::|||||:||.||:.:::.::..||...|.||||||||||||.||.|||.:|||||||||||
Yeast   190 SLFIMDEADKMLSRDFKTIIEQILSFLPPTHQSLLFSATFPLTVKEFMVKHLHKPYEINLMEELT 254

  Fly   267 LKGVTQYYAFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAKMAQ 331
            |||:|||||||:||||:||||||||||||||:|||||||.||||||||||:|||.|||.||:|.|
Yeast   255 LKGITQYYAFVEERQKLHCLNTLFSKLQINQAIIFCNSTNRVELLAKKITDLGYSCYYSHARMKQ 319

  Fly   332 AHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMAETYLHRIGRSGRFGHLGIAI 396
            ..||:|||:||||..|.||||||.|||||:||||||||||||:.||||||||||||||||||:||
Yeast   320 QERNKVFHEFRQGKVRTLVCSDLLTRGIDIQAVNVVINFDFPKTAETYLHRIGRSGRFGHLGLAI 384

  Fly   397 NLITYEDRFDLHRIEKELGTEIKPIPKVIDPALYVA 432
            |||.:.|||:|::||:||||||..||..||.:||||
Yeast   385 NLINWNDRFNLYKIEQELGTEIAAIPATIDKSLYVA 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PTZ00424	60..422	CDD:185609	256/361 (71%)
		DEADc	60..260	CDD:238167	125/199 (63%)
		HELICc	270..398	CDD:238034	105/127 (83%)
DHH1	NP_010121.1	DEADc_DDX6	48..248	CDD:350698	125/199 (63%)
DHH1	NP_010121.1	SF2_C_DEAD	258..387	CDD:350174	106/128 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343072
Domainoid	1	1.000	204	1.000	Domainoid score	I536
eggNOG	1	0.900	-	-		E2759_KOG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3238
Inparanoid	1	1.050	572	1.000	Inparanoid score	I149
Isobase	1	0.950	-	0	Normalized mean entropy	S190
OMA	1	1.010	-	-		QHG53572
OrthoFinder	1	1.000	-	-		FOG0003076
OrthoInspector	1	1.000	-	-		oto100306
orthoMCL	1	0.900	-	-		OOG6_101887
Panther	1	1.100	-	-	LDO	PTHR47960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R307
SonicParanoid	1	1.000	-	-		X2050
TreeFam	1	0.960	-	-
	16	15.740