DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment me31B and ddx6

DIOPT Version :9

Sequence 1:	NP_523533.2	Gene:	me31B / 34364	FlyBaseID:	FBgn0004419	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_684923.1	Gene:	ddx6 / 564633	ZFINID:	ZDB-GENE-070912-83	Length:	484	Species:	Danio rerio

Alignment Length:	438	Identity:	305/438 - (69%)
Similarity:	367/438 - (83%)	Gaps:	12/438 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LNSGHTN--LTSKGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRE 68
            :|:|::.  .|:..||       ...||  ||..|||||||.|.||:|||.|:|||||::|||||
Zfish    52 VNNGNSQPVPTANTII-------KPGDD--WKKNLKLPPKDLRMKTSDVTATKGNEFEDYCLKRE 107

  Fly    69 LLMGIFEKGWERPSPIQEAAIPIALSGKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMV 133
            |||||||.|||:||||||.:|||||||:|:||||||||||:|||.||:||:||..||.|||:|:|
Zfish   108 LLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERIDLKKDSIQAVVIV 172

  Fly   134 PTRELALQTSQICIELAKHL-DIRVMVTTGGTILKDDILRIYQKVQLIIATPGRILDLMDKKVAD 197
            ||||||||.|||||:::||: .::||.|||||.|:|||:|:.:.|.::||||||||||:.|.||.
Zfish   173 PTRELALQVSQICIQVSKHMGGVKVMATTGGTNLRDDIMRLDETVHVVIATPGRILDLIKKGVAK 237

  Fly   198 MSHCRILVLDEADKLLSLDFQGMLDHVILKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINLM 262
            :...:::||||||||||.||..|::.::..|.|..||||:||||||:|:.||..||::|||||||
Zfish   238 VGQVQMIVLDEADKLLSQDFVQMMEEILSSLSKQRQILLYSATFPLSVQKFMNSHLQKPYEINLM 302

  Fly   263 EELTLKGVTQYYAFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHA 327
            |||||||||||||:|.|||||||||||||:||||||||||||:||||||||||::|||.|:||||
Zfish   303 EELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHA 367

  Fly   328 KMAQAHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMAETYLHRIGRSGRFGHL 392
            ||.|.||||||||||.||||||||:||||||||:||||||||||||::.||||||||||||||||
Zfish   368 KMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLGETYLHRIGRSGRFGHL 432

  Fly   393 GIAINLITYEDRFDLHRIEKELGTEIKPIPKVIDPALYVANVGASVGD 440
            |:|||||||:|||:|..||::|||||||||..||.:||||...:..|:
Zfish   433 GLAINLITYDDRFNLKGIEEQLGTEIKPIPSSIDKSLYVAEYHSESGE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PTZ00424	60..422	CDD:185609	270/362 (75%)
		DEADc	60..260	CDD:238167	131/200 (66%)
		HELICc	270..398	CDD:238034	110/127 (87%)
ddx6	XP_684923.1	PTZ00424	99..474	CDD:185609	278/374 (74%)
		DEADc	99..300	CDD:238167	131/200 (66%)
		HELICc	312..438	CDD:238034	108/125 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2813
eggNOG	1	0.900	-	-		E2759_KOG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3238
Inparanoid	1	1.050	614	1.000	Inparanoid score	I869
OMA	1	1.010	-	-		QHG53572
OrthoDB	1	1.010	-	-		D288955at33208
OrthoFinder	1	1.000	-	-		FOG0003076
OrthoInspector	1	1.000	-	-		otm25320
orthoMCL	1	0.900	-	-		OOG6_101887
Panther	1	1.100	-	-	LDO	PTHR47960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R307
SonicParanoid	1	1.000	-	-		X2050
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870