Protein Alignment me31B and DDX19A

DIOPT Version :10

• Sequence 1: NP_523533.2
• Gene: me31B / 34364
• FlyBaseID: FBgn0004419
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_060802.1
• Gene: DDX19A / 55308
• HGNCID: 25628
• Length: 478
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 146/423 - (34%)
• Similarity: 237/423 - (56%)
• Gaps: 34/423 - (8%)

  Fly    15 SKGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLMGIFEKGWE 79
            ::.::|.| |..|..|:......|:..|....:..        ..|||..||.:||.|::..|:.
Human    57 AQSLLNKL-IRSNLVDNTNQVEVLQRDPNSPLYSV--------KSFEELRLKPQLLQGVYAMGFN 112

  Fly    80 RPSPIQEAAIPIALS--GKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTRELALQT 142
            |||.|||.|:|:.|:  .::::|::::|||||.|:.:.:|.:::|:..|.|.|.:.||.||||||
Human   113 RPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPSDRYPQCLCLSPTYELALQT 177

  Fly   143 SQICIELAK-HLDIRVMVTTGGTILKDDILRIYQKV--QLIIATPGRILDLMDK-KVADMSHCRI 203
            .::..::.| :.::::.....|..|:..     ||:  |::|.|||.:||...| |..|....::
Human   178 GKVIEQMGKFYPELKLAYAVRGNKLERG-----QKISEQIVIGTPGTVLDWCSKLKFIDPKKIKV 237

  Fly   204 LVLDEADKLLSLDFQGMLDHVI---LKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINL-MEE 264
            .||||||.:::.  ||..|..|   ..||::.|:|||||||..:|..|.:|.:.:|..|.| .||
Human   238 FVLDEADVMIAT--QGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE 300

  Fly   265 LTLKGVTQYYAFVQER-QKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAK 328
            .||..:.|||.....| :|...|..|:..:.|.|::|||::.:....||.::::.|:....:..:
Human   301 ETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGE 365

  Fly   329 MAQAHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFP------RMAETYLHRIGRSG 387
            |....|..|...||:|..:.||.:::..|||||:.|:||||||.|      ...|||||||||:|
Human   366 MMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTG 430

  Fly   388 RFGHLGIAINLITYEDRFD-LHRIEKELGTEIK 419
            |||..|:|:|::..:...: |:||::....:|:
Human   431 RFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIE 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PRK04537	50..>454	CDD:235307	139/388 (36%)
		DEADc_DDX6	60..260	CDD:350698	77/208 (37%)
DDX19A	NP_060802.1	N-terminal lobe. /evidence=ECO:0000250	2..299		86/257 (33%)
		N-terminal helix. /evidence=ECO:0000250	54..67		3/10 (30%)
		DEAD-like_helicase_N	74..302	CDD:475120	83/242 (34%)
		Q motif	91..119		13/27 (48%)
		DEAD box	241..244		2/2 (100%)
		C-terminal lobe. /evidence=ECO:0000250	300..478		59/164 (36%)
		SF2_C_DEAD	306..442	CDD:350174	52/135 (39%)