DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment me31B and Ddx6

DIOPT Version :9

Sequence 1:	NP_523533.2	Gene:	me31B / 34364	FlyBaseID:	FBgn0004419	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001102762.1	Gene:	Ddx6 / 500988	RGDID:	1564560	Length:	483	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	306/427 - (71%)
Similarity:	364/427 - (85%)	Gaps:	6/427 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HTNLTSKGIINDLQIAGNT---SDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLM 71
            :|:..:.|.....|....|   .||  ||..|||||||.|.||:|||.|:|||||::||||||||
  Rat    47 NTSTINNGTQQQAQSMAATIKPGDD--WKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLM 109

  Fly    72 GIFEKGWERPSPIQEAAIPIALSGKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTR 136
            ||||.|||:||||||.:|||||||:|:||||||||||:|||.||:||::|..||.|||:|:||||
  Rat   110 GIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTR 174

  Fly   137 ELALQTSQICIELAKHL-DIRVMVTTGGTILKDDILRIYQKVQLIIATPGRILDLMDKKVADMSH 200
            |||||.|||||:::||: ..:||.|||||.|:|||:|:...|.::||||||||||:.|.||.:.|
  Rat   175 ELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDH 239

  Fly   201 CRILVLDEADKLLSLDFQGMLDHVILKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINLMEEL 265
            .:::||||||||||.||..:::.:||.|||:.||||:||||||:|:.||..||::||||||||||
  Rat   240 VQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEEL 304

  Fly   266 TLKGVTQYYAFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAKMA 330
            ||||||||||:|.|||||||||||||:||||||||||||:||||||||||::|||.|:||||||.
  Rat   305 TLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMR 369

  Fly   331 QAHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMAETYLHRIGRSGRFGHLGIA 395
            |.||||||||||.||||||||:||||||||:||||||||||||::||||||||||||||||||:|
  Rat   370 QEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLA 434

  Fly   396 INLITYEDRFDLHRIEKELGTEIKPIPKVIDPALYVA 432
            ||||||:|||:|..||::|||||||||..||.:||||
  Rat   435 INLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVA 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PTZ00424	60..422	CDD:185609	273/362 (75%)
		DEADc	60..260	CDD:238167	133/200 (67%)
		HELICc	270..398	CDD:238034	111/127 (87%)
Ddx6	NP_001102762.1	DEADc_DDX6	98..299	CDD:350698	133/200 (67%)
Ddx6	NP_001102762.1	SF2_C_DEAD	309..438	CDD:350174	112/128 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2698
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3238
Inparanoid	1	1.050	618	1.000	Inparanoid score	I851
OMA	1	1.010	-	-		QHG53572
OrthoDB	1	1.010	-	-		D288955at33208
OrthoFinder	1	1.000	-	-		FOG0003076
OrthoInspector	1	1.000	-	-		oto98705
orthoMCL	1	0.900	-	-		OOG6_101887
Panther	1	1.100	-	-	LDO	PTHR47960
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2050
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980