Protein Alignment me31B and DDX25

DIOPT Version :10

• Sequence 1: NP_523533.2
• Gene: me31B / 34364
• FlyBaseID: FBgn0004419
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_037396.3
• Gene: DDX25 / 29118
• HGNCID: 18698
• Length: 483
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 156/485 - (32%)
• Similarity: 244/485 - (50%)
• Gaps: 95/485 - (19%)

  Fly     3 TEKLNSGHTNLTS----------------KGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTD 51
            :|:|||..:||:.                .|.||::    |..|:                  .|
Human    15 SERLNSHFSNLSQPRKNLWGIKSTAVRNIDGSINNI----NEDDE------------------ED 57

  Fly    52 VTDTRGNE---------------------------------FEEFCLKRELLMGIFEKGWERPSP 83
            |.|...|.                                 |||..||.|||.||:..|:.|||.
Human    58 VVDLAANSLLNKLIHQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSK 122

  Fly    84 IQEAAIPIALS--GKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTRELALQTSQIC 146
            |||.|:|:.|:  .::::|::::|||||.|:.:.:|.:::..:.:.|.|.:.||.||||||.::.
Human   123 IQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVV 187

  Fly   147 IELAKH-LDIRVMVTTGGTILK--DDILRIYQKVQLIIATPGRILDLMDK-KVADMSHCRILVLD 207
            .::.|. :|::||....|..:.  .||.:     |:||.|||.:||...| |:.|::..|:.|||
Human   188 EQMGKFCVDVQVMYAIRGNRIPRGTDITK-----QIIIGTPGTVLDWCFKLKLIDLTKIRVFVLD 247

  Fly   208 EADKLLSLDFQGMLDHVI---LKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINL-MEELTLK 268
            |||  :.:|.||..||.|   ..||.:.|:|||||||..:|.:|.|:.:.:|..|.| .|||||.
Human   248 EAD--VMIDTQGFSDHSIRIQRALPSECQMLLFSATFEDSVWHFAERIIPDPNVIKLRKEELTLN 310

  Fly   269 GVTQYYAFVQERQ-KVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAKMAQA 332
            .:.|||...:.|: |...|..::..:.|.|:||||.:.:..:.|..::.:.|:....:..::...
Human   311 NIRQYYVLCEHRKDKYQALCNIYGSITIGQAIIFCQTRRNAKWLTVEMIQDGHQVSLLSGELTVE 375

  Fly   333 HRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMA------ETYLHRIGRSGRFGH 391
            .|..:...||.|..:.|:.:::..|||||:.|.:|:|||.|...      |||||||||:||||.
Human   376 QRASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVKQGEEPDYETYLHRIGRTGRFGK 440

  Fly   392 LGIAINLITYEDRFDLHRIEKELGTEIKPI 421
            .|:|.|:|..::...|.:|:....:.||.:
Human   441 KGLAFNMIEVDELPSLMKIQDHFNSSIKQL 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PRK04537	50..>454	CDD:235307	145/422 (34%)
		DEADc_DDX6	60..260	CDD:350698	83/208 (40%)
DDX25	NP_037396.3	Nuclear export signal. /evidence=ECO:0000250	61..74		1/12 (8%)
		DEADc_DDX25	80..308	CDD:350806	87/234 (37%)
		Q motif	97..125		15/27 (56%)
		Nuclear localization signal. /evidence=ECO:0000250	100..114		9/13 (69%)
		DEAD box	247..250		2/2 (100%)
		SF2_C_DEAD	312..448	CDD:350174	46/135 (34%)