DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment me31B and ste13

DIOPT Version :9

Sequence 1:	NP_523533.2	Gene:	me31B / 34364	FlyBaseID:	FBgn0004419	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_596324.1	Gene:	ste13 / 2541216	PomBaseID:	SPBC776.09	Length:	485	Species:	Schizosaccharomyces pombe

Alignment Length:	417	Identity:	287/417 - (68%)
Similarity:	345/417 - (82%)	Gaps:	1/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SKGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLMGIFEKGWE 79
            ::.:|..|:.| |.:|...:|.::|..|.|.|.||.|||.|||.|||::.|||||||||||.|:|
pombe     2 AESLIQKLENA-NLNDRESFKGQMKAQPVDMRPKTEDVTKTRGTEFEDYYLKRELLMGIFEAGFE 65

  Fly    80 RPSPIQEAAIPIALSGKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTRELALQTSQ 144
            |||||||.:|||||||:|:|||||||||||.|:.||.||::|..|..||.|::||||||||||||
pombe    66 RPSPIQEESIPIALSGRDILARAKNGTGKTAAFVIPSLEKVDTKKSKIQTLILVPTRELALQTSQ 130

  Fly   145 ICIELAKHLDIRVMVTTGGTILKDDILRIYQKVQLIIATPGRILDLMDKKVADMSHCRILVLDEA 209
            :|..|.||::::||||||||.|:|||:|:...|.:::.||||:|||..|.|||.|.|...|:|||
pombe   131 VCKTLGKHMNVKVMVTTGGTTLRDDIIRLNDTVHIVVGTPGRVLDLAGKGVADFSECTTFVMDEA 195

  Fly   210 DKLLSLDFQGMLDHVILKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINLMEELTLKGVTQYY 274
            |||||.:|..:::.::...||:.||.|:||||||.|||||:|||.:|||||||:||||:||||||
pombe   196 DKLLSPEFTPIIEQLLSYFPKNRQISLYSATFPLIVKNFMDKHLNKPYEINLMDELTLRGVTQYY 260

  Fly   275 AFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAKMAQAHRNRVFH 339
            |||.|.|||||||||||||||||||||||||.||||||||||||||.|:|.||||.|:|||||||
pombe   261 AFVDESQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMLQSHRNRVFH 325

  Fly   340 DFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMAETYLHRIGRSGRFGHLGIAINLITYEDR 404
            :||.|:|||||||||.|||||:||||||||||||:.||||||||||||||||.|:||:.|::.||
pombe   326 NFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHRGLAISFISWADR 390

  Fly   405 FDLHRIEKELGTEIKPIPKVIDPALYV 431
            |:|:|||.||||||:|||..|||:|||
pombe   391 FNLYRIENELGTEIQPIPPSIDPSLYV 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PTZ00424	60..422	CDD:185609	260/361 (72%)
		DEADc	60..260	CDD:238167	126/199 (63%)
		HELICc	270..398	CDD:238034	110/127 (87%)
ste13	NP_596324.1	PTZ00424	15..411	CDD:185609	277/395 (70%)
		DEADc	46..246	CDD:238167	126/199 (63%)
		HELICc	256..384	CDD:238034	110/127 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	201	1.000	Domainoid score	I649
eggNOG	1	0.900	-	-		E2759_KOG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3238
Inparanoid	1	1.050	581	1.000	Inparanoid score	I167
OMA	1	1.010	-	-		QHG53572
OrthoFinder	1	1.000	-	-		FOG0003076
OrthoInspector	1	1.000	-	-		oto102075
orthoMCL	1	0.900	-	-		OOG6_101887
Panther	1	1.100	-	-	LDO	PTHR47960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R307
SonicParanoid	1	1.000	-	-		X2050
TreeFam	1	0.960	-	-
	14	13.860