DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment me31B and DDX6

DIOPT Version :9

Sequence 1:	NP_523533.2	Gene:	me31B / 34364	FlyBaseID:	FBgn0004419	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001244120.1	Gene:	DDX6 / 1656	HGNCID:	2747	Length:	483	Species:	Homo sapiens

Alignment Length:	427	Identity:	307/427 - (71%)
Similarity:	364/427 - (85%)	Gaps:	6/427 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HTNLTSKGIINDLQIAGNT---SDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLM 71
            :||..:.|.....|....|   .||  ||..|||||||.|.||:|||.|:|||||::||||||||
Human    47 NTNTINNGTQQQAQSMTTTIKPGDD--WKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLM 109

  Fly    72 GIFEKGWERPSPIQEAAIPIALSGKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTR 136
            ||||.|||:||||||.:|||||||:|:||||||||||:|||.||:||::|..||.|||:|:||||
Human   110 GIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTR 174

  Fly   137 ELALQTSQICIELAKHL-DIRVMVTTGGTILKDDILRIYQKVQLIIATPGRILDLMDKKVADMSH 200
            |||||.|||||:::||: ..:||.|||||.|:|||:|:...|.::||||||||||:.|.||.:.|
Human   175 ELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDH 239

  Fly   201 CRILVLDEADKLLSLDFQGMLDHVILKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINLMEEL 265
            .:::||||||||||.||..:::.:||.|||:.||||:||||||:|:.||..||::||||||||||
Human   240 VQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEEL 304

  Fly   266 TLKGVTQYYAFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAKMA 330
            ||||||||||:|.|||||||||||||:||||||||||||:||||||||||::|||.|:||||||.
Human   305 TLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMR 369

  Fly   331 QAHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMAETYLHRIGRSGRFGHLGIA 395
            |.||||||||||.||||||||:||||||||:||||||||||||::||||||||||||||||||:|
Human   370 QEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLA 434

  Fly   396 INLITYEDRFDLHRIEKELGTEIKPIPKVIDPALYVA 432
            ||||||:|||:|..||::|||||||||..||.:||||
Human   435 INLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVA 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PTZ00424	60..422	CDD:185609	273/362 (75%)
		DEADc	60..260	CDD:238167	133/200 (67%)
		HELICc	270..398	CDD:238034	111/127 (87%)
DDX6	NP_001244120.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Q motif	96..124		23/27 (85%)
		DEADc_DDX6	98..299	CDD:350698	133/200 (67%)
		DEAD box	246..249		2/2 (100%)
		Gyf binding. /evidence=ECO:0000269\|PubMed:31439631	286..316		24/29 (83%)
		RecA-like domain 2. /evidence=ECO:0000269\|PubMed:31439631	307..483		139/165 (84%)
		SF2_C_DEAD	309..438	CDD:350174	112/128 (88%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2791
eggNOG	1	0.900	-	-		E2759_KOG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3238
Inparanoid	1	1.050	619	1.000	Inparanoid score	I887
Isobase	1	0.950	-	0	Normalized mean entropy	S190
OMA	1	1.010	-	-		QHG53572
OrthoDB	1	1.010	-	-		D288955at33208
OrthoFinder	1	1.000	-	-		FOG0003076
OrthoInspector	1	1.000	-	-		oto91633
orthoMCL	1	0.900	-	-		OOG6_101887
Panther	1	1.100	-	-	LDO	PTHR47960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R307
SonicParanoid	1	1.000	-	-		X2050
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.860