Protein Alignment me31B and DDX19B

DIOPT Version :10

• Sequence 1: NP_523533.2
• Gene: me31B / 34364
• FlyBaseID: FBgn0004419
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_001350867.1
• Gene: DDX19B / 11269
• HGNCID: 2742
• Length: 484
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 147/423 - (34%)
• Similarity: 236/423 - (55%)
• Gaps: 34/423 - (8%)

  Fly    15 SKGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLMGIFEKGWE 79
            ::.::|.| |..|..|:......|:..|....:..        ..|||..||.:||.|::..|:.
Human    63 AQSLLNKL-IRSNLVDNTNQVEVLQRDPNSPLYSV--------KSFEELRLKPQLLQGVYAMGFN 118

  Fly    80 RPSPIQEAAIPIALS--GKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTRELALQT 142
            |||.|||.|:|:.|:  .::::|::::|||||.|:.:.:|.|::|...|.|.|.:.||.||||||
Human   119 RPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQT 183

  Fly   143 SQICIELAK-HLDIRVMVTTGGTILKDDILRIYQKV--QLIIATPGRILDLMDK-KVADMSHCRI 203
            .::..::.| :.::::.....|..|:..     ||:  |::|.|||.:||...| |..|....::
Human   184 GKVIEQMGKFYPELKLAYAVRGNKLERG-----QKISEQIVIGTPGTVLDWCSKLKFIDPKKIKV 243

  Fly   204 LVLDEADKLLSLDFQGMLDHVI---LKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINL-MEE 264
            .||||||.:::.  ||..|..|   ..||::.|:|||||||..:|..|.:|.:.:|..|.| .||
Human   244 FVLDEADVMIAT--QGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE 306

  Fly   265 LTLKGVTQYYAFVQER-QKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAK 328
            .||..:.|||.....| :|...|..|:..:.|.|::|||::.:....||.::::.|:....:..:
Human   307 ETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGE 371

  Fly   329 MAQAHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFP------RMAETYLHRIGRSG 387
            |....|..|...||:|..:.||.:::..|||||:.|:||||||.|      ...|||||||||:|
Human   372 MMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTG 436

  Fly   388 RFGHLGIAINLITYEDRFD-LHRIEKELGTEIK 419
            |||..|:|:|::..:...: |:||::....:|:
Human   437 RFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIE 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
me31B	NP_523533.2	PRK04537	50..>454	CDD:235307	140/388 (36%)
		DEADc_DDX6	60..260	CDD:350698	78/208 (38%)
DDX19B	NP_001350867.1	DEAD-like_helicase_N	80..308	CDD:475120	84/242 (35%)
		SF2_C_DEAD	312..448	CDD:350174	52/135 (39%)