DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1delta and EFCC1

DIOPT Version :9

Sequence 1:	NP_609361.1	Gene:	eEF1delta / 34363	FlyBaseID:	FBgn0032198	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_001364429.1	Gene:	EFCC1 / 79825	HGNCID:	25692	Length:	599	Species:	Homo sapiens

Alignment Length:	285	Identity:	58/285 - (20%)
Similarity:	92/285 - (32%)	Gaps:	109/285 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RFYEGPQKVTDRSHYSPLVSEIAKAREHIQNSLEKIDGVTLDDGLNSELAKRLAQLEGEHKELKT 86
            |...|..:|..|:.         :||:.:..||.::          .||.....|:.|
Human   273 RLRRGQAEVRRRAE---------EARQVVLRSLHRV----------RELEALAQQVPG------- 311

  Fly    87 QVSLLNELLTATVKRLETQL-------------KLTNGVSKEPEVEAKKPE-------------- 124
                    |...|:|||.:|             :|.|   .||..::.:||
Human   312 --------LQRWVRRLEAELQRYRSEDSQLPTPQLAN---PEPGDKSNEPEDAGTRDPDPTPEGA 365

  Fly   125 ----------ANDDDDDVDLFGS-----DSEEEDGEAARIREERLAAYAAKKAKKVQIIAKSNII 174
                      |.|:..|..||.|     .|:||:.|..|.:||:....|..|....::.:...
Human   366 WQSDSSSGSRALDEAVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRG-- 428

  Fly   175 LDVKPWDDETDLKVMETEIRKITQDGLLWGASKFVPVAFGIQKLSISCVVE-------------- 225
                ..||:|..|:|       |..|...||:.  ....|..:..|:.:||
Human   429 ----RCDDQTAEKLM-------TYFGHFGGANH--AHTLGELEACIAMLVEQLRTQGCGGRTLGT 480

  Fly   226 -DDKVSIDWLTEEIEKLEDFVQSVD 249
             :::..:....||.|.|...:|.|:
Human   481 SEEEAELQQKVEENEHLRLELQMVE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1delta	NP_609361.1	EF-1_beta_acid	134..>156	CDD:287546	10/26 (38%)
eEF1delta	NP_609361.1	EF1B	168..256	CDD:238181	19/97 (20%)
EFCC1	NP_001364429.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		CCD48	18..599	CDD:406280	58/285 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..198
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930