Protein Alignment CG5708 and LHX2

DIOPT Version :10

• Sequence 1: NP_609359.1
• Gene: CG5708 / 34361
• FlyBaseID: FBgn0032196
• Length: 241
• Species: Drosophila melanogaster
• Sequence 2: NP_004780.3
• Gene: LHX2 / 9355
• HGNCID: 6594
• Length: 406
• Species: Homo sapiens
• Alignment Length: 233
• Identity: 73/233 - (31%)
• Similarity: 95/233 - (40%)
• Gaps: 72/233 - (30%)

  Fly    40 DTVETNSNISSSQLSFMDESSNDFNNQQLIHSNSLIKVCGGCGDKISDRYLLYALDRYWHNGCLK 104
            ||..|..:|||.:.:                      :|.|||.||||||.|.|:|:.||..|||
Human    37 DTETTMPSISSDRAA----------------------LCAGCGGKISDRYYLLAVDKQWHMRCLK 79

  Fly   105 CHCCGAMLAEVGSSCFTRRGLILCKKDYSSMFGCSGVCSGCGETIPPSELVAKALTGINNIDLQN 169
            |..|...| |...:||::.|.|.||:||...|.... |:.|...|..||:|.:|.      ||
Human    80 CCECKLNL-ESELTCFSKDGSIYCKEDYYRRFSVQR-CARCHLGISASEMVMRAR------DL-- 134

  Fly   170 QQKQIINCVFHLRCFSCAKCGSSLRPGDRYTMLGASLVCEQDWHKLLKG--PANSN--------- 223
                    |:||.||:|..|...|..||.:.|..:.:.|...:..||:|  ||:.|
Human   135 --------VYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAA 191

  Fly   224 ----------GTLGQRK---------GKV--GRPRRSK 240
                      |..|...         |.|  ||||:.|
Human   192 AAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRK 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5708	NP_609359.1	LIM1_LMO4	78..132	CDD:188772	28/53 (53%)
		LIM	142..212	CDD:413332	21/69 (30%)
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	31/85 (36%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	21/74 (28%)
		COG5576	<247..378	CDD:227863
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..270
		Homeodomain	267..323	CDD:459649
		Nuclear localization signal. /evidence=ECO:0000255	307..323
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	328..374
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..406