DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4908 and Afg3l1

DIOPT Version :9

Sequence 1:	NP_609358.1	Gene:	CG4908 / 34360	FlyBaseID:	FBgn0032195	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_473411.2	Gene:	Afg3l1 / 114896	MGIID:	1928277	Length:	789	Species:	Mus musculus

Alignment Length:	377	Identity:	94/377 - (24%)
Similarity:	149/377 - (39%)	Gaps:	112/377 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EVPCRDKSYQWLLKWITIRGARKTQHLSVETNFVQNDNGTIKTSYDFIPSIG-----KHLFQY-- 109
            |.|..||.::.|    .:.||      .|...|:          |.:....|     ||..||
Mouse   131 EFPWDDKDFRSL----AVLGA------GVAAGFL----------YFYFRDPGKEITWKHFVQYYL 175

  Fly   110 -KGNWIQVERTREQQTLDLHMGVPWETVTLTAFGNNKGIYFDI---------LEEAR-QLALEAT 163
             :|...::|...:|....:  .||..|       :.:.::|:|         ||.|: :|.:|.|
Mouse   176 ARGLVDRLEVVNKQFVRVI--PVPGTT-------SERFVWFNIGSVDTFERNLESAQWELGIEPT 231

  Fly   164 EGKTVLYT--AMGAEWRPFG----------HPRRRRPTGSVVLDRG--------TSQRI------ 202
            ....|:||  :.|:..|...          :..||.|.|:....||        |:.:|
Mouse   232 NQAAVVYTTESDGSFLRSLVPTLVLVSILLYAMRRGPMGTGRGGRGGGLFSVGETTAKILKNNID 296

  Fly   203 -----IADCQD----------FIKSSLWYTQRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSV 252
                 :|.|::          |:|:...|...|....:|.:|.||||.||:....|.|||.....
Mouse   297 VRFADVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPF 361

  Fly   253 CLLNLSE-----RGLTDDRLNHLLNVAPEQS--IILLEDIDAAFVSRE-------ATPQQKSAFD 303
            ..:|.||     .|:...|:..:..:|.:.:  |:.:::|||  :.|:       ...:|::
Mouse   362 ITVNGSEFLEMFVGVGPARVRDMFAMARKHAPCILFIDEIDA--IGRKRGRGHLGGQSEQEN--- 421

  Fly   304 GLNRITFSGLLNCLDGVGSTEARIVFMTTNYIDRLDPALVRPGRIDLKEYIG 355
                 |.:.:|..:||..|:...:|...||..|.|||||.||||.|.:.|||
Mouse   422 -----TLNQMLVEMDGFNSSTNVVVLAGTNRPDILDPALTRPGRFDRQIYIG 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4908	NP_609358.1	BCS1_N	23..192	CDD:214980	38/169 (22%)
CG4908	NP_609358.1	RecA-like_BCS1	202..354	CDD:410918	50/186 (27%)
Afg3l1	NP_473411.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..121
		FtsH_ext	142..233	CDD:284011	25/119 (21%)
		FtsH_fam	281..738	CDD:273520	54/198 (27%)
		AAA	337..468	CDD:278434	43/140 (31%)
		Peptidase_M41	554..736	CDD:279742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..789
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900