DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha6 and PRE5

DIOPT Version :9

Sequence 1:	NP_001285798.1	Gene:	Prosalpha6 / 34359	FlyBaseID:	FBgn0250843	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_014045.1	Gene:	PRE5 / 855362	SGDID:	S000004931	Length:	234	Species:	Saccharomyces cerevisiae

Alignment Length:	239	Identity:	113/239 - (47%)
Similarity:	153/239 - (64%)	Gaps:	8/239 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRNQYDSDVTVWSPQGRLHQVEYAMEAVKLGTATVGLKNKDYAVLVALCKPTSELSDTQRKIIP 65
            ||||.||.|...:||.|||.|||||:||:|.|:.||||::..:||||||.:...|||..|:|||.
Yeast     1 MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQKKIIK 65

  Fly    66 IDDHLGISIAGLTADARVLSRYLRSECLNYKH-SYDTTYPVSRLITNLGNKMQTTTQRYDRRPYG 129
            .|:|:|:|:|||..||||||.|||.:| ||.. .::....|.|....|.:|.|..||.|..||||
Yeast    66 CDEHMGLSLAGLAPDARVLSNYLRQQC-NYSSLVFNRKLAVERAGHLLCDKAQKNTQSYGGRPYG 129

  Fly   130 VGLLVAGYDERGPHIYQVTPSATFFNCKANSIGSRSQSARTYLEKNLNKF--LDSSKDEIIRHGI 192
            ||||:.|||:.|.|:.:..||.........:||:|||.|:||||:.|:.|  :|.:.||:|:.|:
Yeast   130 VGLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFIKIDGNPDELIKAGV 194

  Fly   193 RAILGTLPTDEQGKDAGQYDITVAIVGKDQPFTILSNKDSAKHV 236
            .||..:|..:....|    ::::||||||.||||...:..||::
Yeast   195 EAISQSLRDESLTVD----NLSIAIVGKDTPFTIYDGEAVAKYI 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha6	NP_001285798.1	PRE1	4..231	CDD:223711	108/229 (47%)
Prosalpha6	NP_001285798.1	proteasome_alpha_type_1	6..219	CDD:239718	99/215 (46%)
PRE5	NP_014045.1	Ntn_hydrolase	6..217	CDD:412394	99/215 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343185
Domainoid	1	1.000	152	1.000	Domainoid score	I920
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I802
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53705
OrthoFinder	1	1.000	-	-		FOG0003679
OrthoInspector	1	1.000	-	-		otm46859
orthoMCL	1	0.900	-	-		OOG6_102143
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1003
SonicParanoid	1	1.000	-	-		X2552
TreeFam	1	0.960	-	-
	14	13.790